Cerium oxide nanoparticles inhibit the migration and proliferation of gastric cancer by increasing DHX15 expression

Yu-Feng Xiao,1 Jian-Mei Li,2 Su-Min Wang,1 Xin Yong,1 Bo Tang,1 Meng-Meng Jie,1 Hui Dong,1 Xiao-Chao Yang,2 Shi-Ming Yang1 1Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, People’s Republic of China; 2School of Biomedical Engineering, Third...

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Autores principales:	Xiao YF, Li JM, Wang SM, Yong X, Tang B, Jie MM, Dong H, Yang XC, Yang SM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Cerium oxide nanoparticles gastric cancer DHX15 p38 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/23da7ce2e609422daa215f2d76082f1c
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spelling	oai:doaj.org-article:23da7ce2e609422daa215f2d76082f1c2021-12-02T03:11:30ZCerium oxide nanoparticles inhibit the migration and proliferation of gastric cancer by increasing DHX15 expression1178-2013https://doaj.org/article/23da7ce2e609422daa215f2d76082f1c2016-07-01T00:00:00Zhttps://www.dovepress.com/cerium-oxide-nanoparticles-inhibit-the-migration-and-proliferation-of--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yu-Feng Xiao,1 Jian-Mei Li,2 Su-Min Wang,1 Xin Yong,1 Bo Tang,1 Meng-Meng Jie,1 Hui Dong,1 Xiao-Chao Yang,2 Shi-Ming Yang1 1Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, People’s Republic of China; 2School of Biomedical Engineering, Third Military Medical University, Chongqing, People’s Republic of China Abstract: Gastric cancer is one of the leading causes of tumor-related deaths in the world. Current treatment options do not satisfy doctors and patients, and new therapies are therefore needed. Cerium oxide nanoparticles (CNPs) have been studied as a potential therapeutic approach for treating many diseases. However, their effects on human gastric cancer are currently unknown. Therefore, in this study, we aimed to characterize the effects of CNPs on human gastric cancer cell lines (MKN28 and BGC823). Gastric cancer cells were cocultured with different concentrations of CNPs, and proliferation and migration were measured both in vitro and in vivo. We found that CNPs inhibited the migration of gastric cancer cells when applied at different concentrations, but only a relatively high concentration (10 µg/mL) of CNPs suppressed proliferation. Furthermore, we found that CNPs increased the expression of DHX15 and its downstream signaling pathways. We therefore provide evidence showing that CNPs may be a promising approach to suppress malignant activity of gastric cancer by increasing the expression of DHX15. Keywords: cerium oxide nanoparticles, gastric cancer, DHX15, p38Xiao YFLi JMWang SMYong XTang BJie MMDong HYang XCYang SMDove Medical PressarticleCerium oxide nanoparticlesgastric cancerDHX15p38Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 3023-3034 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cerium oxide nanoparticles gastric cancer DHX15 p38 Medicine (General) R5-920
spellingShingle	Cerium oxide nanoparticles gastric cancer DHX15 p38 Medicine (General) R5-920 Xiao YF Li JM Wang SM Yong X Tang B Jie MM Dong H Yang XC Yang SM Cerium oxide nanoparticles inhibit the migration and proliferation of gastric cancer by increasing DHX15 expression
description	Yu-Feng Xiao,1 Jian-Mei Li,2 Su-Min Wang,1 Xin Yong,1 Bo Tang,1 Meng-Meng Jie,1 Hui Dong,1 Xiao-Chao Yang,2 Shi-Ming Yang1 1Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, People’s Republic of China; 2School of Biomedical Engineering, Third Military Medical University, Chongqing, People’s Republic of China Abstract: Gastric cancer is one of the leading causes of tumor-related deaths in the world. Current treatment options do not satisfy doctors and patients, and new therapies are therefore needed. Cerium oxide nanoparticles (CNPs) have been studied as a potential therapeutic approach for treating many diseases. However, their effects on human gastric cancer are currently unknown. Therefore, in this study, we aimed to characterize the effects of CNPs on human gastric cancer cell lines (MKN28 and BGC823). Gastric cancer cells were cocultured with different concentrations of CNPs, and proliferation and migration were measured both in vitro and in vivo. We found that CNPs inhibited the migration of gastric cancer cells when applied at different concentrations, but only a relatively high concentration (10 µg/mL) of CNPs suppressed proliferation. Furthermore, we found that CNPs increased the expression of DHX15 and its downstream signaling pathways. We therefore provide evidence showing that CNPs may be a promising approach to suppress malignant activity of gastric cancer by increasing the expression of DHX15. Keywords: cerium oxide nanoparticles, gastric cancer, DHX15, p38
format	article
author	Xiao YF Li JM Wang SM Yong X Tang B Jie MM Dong H Yang XC Yang SM
author_facet	Xiao YF Li JM Wang SM Yong X Tang B Jie MM Dong H Yang XC Yang SM
author_sort	Xiao YF
title	Cerium oxide nanoparticles inhibit the migration and proliferation of gastric cancer by increasing DHX15 expression
title_short	Cerium oxide nanoparticles inhibit the migration and proliferation of gastric cancer by increasing DHX15 expression
title_full	Cerium oxide nanoparticles inhibit the migration and proliferation of gastric cancer by increasing DHX15 expression
title_fullStr	Cerium oxide nanoparticles inhibit the migration and proliferation of gastric cancer by increasing DHX15 expression
title_full_unstemmed	Cerium oxide nanoparticles inhibit the migration and proliferation of gastric cancer by increasing DHX15 expression
title_sort	cerium oxide nanoparticles inhibit the migration and proliferation of gastric cancer by increasing dhx15 expression
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/23da7ce2e609422daa215f2d76082f1c
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_version_	1718401906282332160

Cerium oxide nanoparticles inhibit the migration and proliferation of gastric cancer by increasing DHX15 expression

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