Cortical microstructural changes associated with treated aphasia recovery

Abstract Objectives To investigate the hypothesis that language recovery in post‐stroke aphasia is associated with structural brain changes. Methods We evaluated whether treatment‐induced improvement in naming is associated with reorganization of tissue microstructure within residual cortical region...

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Autores principales:	Allen J. Chang, Janina Wilmskoetter, Julius Fridriksson, Emilie T. McKinnon, Lorelei P. Johnson, Alexandra Basilakos, Jens H. Jensen, Chris Rorden, Leonardo Bonilha
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/23dbd687fbb14028bf91f13dcee3dbd3
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spelling	oai:doaj.org-article:23dbd687fbb14028bf91f13dcee3dbd32021-11-19T13:55:31ZCortical microstructural changes associated with treated aphasia recovery2328-950310.1002/acn3.51445https://doaj.org/article/23dbd687fbb14028bf91f13dcee3dbd32021-09-01T00:00:00Zhttps://doi.org/10.1002/acn3.51445https://doaj.org/toc/2328-9503Abstract Objectives To investigate the hypothesis that language recovery in post‐stroke aphasia is associated with structural brain changes. Methods We evaluated whether treatment‐induced improvement in naming is associated with reorganization of tissue microstructure within residual cortical regions. To this end, we performed a retrospective longitudinal treatment study using comprehensive language‐linguistic assessments and diffusion MRI sequences optimized for the assessment of complex microstructure (diffusional kurtosis imaging) to evaluate the relationship between language treatment response and cortical changes in 26 individuals with chronic stroke‐induced aphasia. We employed elastic net statistical models controlling for baseline factors including age, sex, and time since the stroke, as well as lesion volume. Results We observed that improved naming accuracy (Philadelphia Naming Test) was statistically associated with increased post‐treatment microstructural integrity in the left posterior superior temporal gyrus. Moreover, increase in microstructural integrity in the left middle temporal gyrus and left inferior temporal gyrus was specifically associated with a decrease in semantic paraphasias. This longitudinal relationship between brain tissue integrity and language improvement was not observed in other non‐language related brain regions. Interpretation Our findings provide evidence that structural brain changes in the preserved left hemisphere regions are associated with treatment‐induced language recovery in aphasia and are part of the mechanisms supporting language and brain injury recovery.Allen J. ChangJanina WilmskoetterJulius FridrikssonEmilie T. McKinnonLorelei P. JohnsonAlexandra BasilakosJens H. JensenChris RordenLeonardo BonilhaWileyarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENAnnals of Clinical and Translational Neurology, Vol 8, Iss 9, Pp 1884-1894 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Allen J. Chang Janina Wilmskoetter Julius Fridriksson Emilie T. McKinnon Lorelei P. Johnson Alexandra Basilakos Jens H. Jensen Chris Rorden Leonardo Bonilha Cortical microstructural changes associated with treated aphasia recovery
description	Abstract Objectives To investigate the hypothesis that language recovery in post‐stroke aphasia is associated with structural brain changes. Methods We evaluated whether treatment‐induced improvement in naming is associated with reorganization of tissue microstructure within residual cortical regions. To this end, we performed a retrospective longitudinal treatment study using comprehensive language‐linguistic assessments and diffusion MRI sequences optimized for the assessment of complex microstructure (diffusional kurtosis imaging) to evaluate the relationship between language treatment response and cortical changes in 26 individuals with chronic stroke‐induced aphasia. We employed elastic net statistical models controlling for baseline factors including age, sex, and time since the stroke, as well as lesion volume. Results We observed that improved naming accuracy (Philadelphia Naming Test) was statistically associated with increased post‐treatment microstructural integrity in the left posterior superior temporal gyrus. Moreover, increase in microstructural integrity in the left middle temporal gyrus and left inferior temporal gyrus was specifically associated with a decrease in semantic paraphasias. This longitudinal relationship between brain tissue integrity and language improvement was not observed in other non‐language related brain regions. Interpretation Our findings provide evidence that structural brain changes in the preserved left hemisphere regions are associated with treatment‐induced language recovery in aphasia and are part of the mechanisms supporting language and brain injury recovery.
format	article
author	Allen J. Chang Janina Wilmskoetter Julius Fridriksson Emilie T. McKinnon Lorelei P. Johnson Alexandra Basilakos Jens H. Jensen Chris Rorden Leonardo Bonilha
author_facet	Allen J. Chang Janina Wilmskoetter Julius Fridriksson Emilie T. McKinnon Lorelei P. Johnson Alexandra Basilakos Jens H. Jensen Chris Rorden Leonardo Bonilha
author_sort	Allen J. Chang
title	Cortical microstructural changes associated with treated aphasia recovery
title_short	Cortical microstructural changes associated with treated aphasia recovery
title_full	Cortical microstructural changes associated with treated aphasia recovery
title_fullStr	Cortical microstructural changes associated with treated aphasia recovery
title_full_unstemmed	Cortical microstructural changes associated with treated aphasia recovery
title_sort	cortical microstructural changes associated with treated aphasia recovery
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/23dbd687fbb14028bf91f13dcee3dbd3
work_keys_str_mv	AT allenjchang corticalmicrostructuralchangesassociatedwithtreatedaphasiarecovery AT janinawilmskoetter corticalmicrostructuralchangesassociatedwithtreatedaphasiarecovery AT juliusfridriksson corticalmicrostructuralchangesassociatedwithtreatedaphasiarecovery AT emilietmckinnon corticalmicrostructuralchangesassociatedwithtreatedaphasiarecovery AT loreleipjohnson corticalmicrostructuralchangesassociatedwithtreatedaphasiarecovery AT alexandrabasilakos corticalmicrostructuralchangesassociatedwithtreatedaphasiarecovery AT jenshjensen corticalmicrostructuralchangesassociatedwithtreatedaphasiarecovery AT chrisrorden corticalmicrostructuralchangesassociatedwithtreatedaphasiarecovery AT leonardobonilha corticalmicrostructuralchangesassociatedwithtreatedaphasiarecovery
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Cortical microstructural changes associated with treated aphasia recovery

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