A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer

A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer

Advanced colorectal cancers are characterised by intra-tumour heterogeneity dictated by neutral evolution. Here the authors analyse early colorectal tumours by whole-exome sequencing and find that Darwinian evolution determines the fate of early lesions in colorectal adenoma and carcinoma in situ.

Guardado en:
Detalles Bibliográficos
Autores principales: Tomoko Saito, Atsushi Niida, Ryutaro Uchi, Hidenari Hirata, Hisateru Komatsu, Shotaro Sakimura, Shuto Hayashi, Sho Nambara, Yosuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Takaaki Masuda, Keishi Sugimachi, Taro Tobo, Haruto Nishida, Tsutomu Daa, Kenichi Chiba, Yuichi Shiraishi, Tetsuichi Yoshizato, Masaaki Kodama, Tadayoshi Okimoto, Kazuhiro Mizukami, Ryo Ogawa, Kazuhisa Okamoto, Mitsutaka Shuto, Kensuke Fukuda, Yusuke Matsui, Teppei Shimamura, Takanori Hasegawa, Yuichiro Doki, Satoshi Nagayama, Kazutaka Yamada, Mamoru Kato, Tatsuhiro Shibata, Masaki Mori, Hiroyuki Aburatani, Kazunari Murakami, Yutaka Suzuki, Seishi Ogawa, Satoru Miyano, Koshi Mimori
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/23dc0cb8e5fb48bfbd8d0dc7663ee372
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:23dc0cb8e5fb48bfbd8d0dc7663ee372
record_format dspace
spelling oai:doaj.org-article:23dc0cb8e5fb48bfbd8d0dc7663ee3722021-12-02T15:34:00ZA temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer10.1038/s41467-018-05226-02041-1723https://doaj.org/article/23dc0cb8e5fb48bfbd8d0dc7663ee3722018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05226-0https://doaj.org/toc/2041-1723Advanced colorectal cancers are characterised by intra-tumour heterogeneity dictated by neutral evolution. Here the authors analyse early colorectal tumours by whole-exome sequencing and find that Darwinian evolution determines the fate of early lesions in colorectal adenoma and carcinoma in situ.Tomoko SaitoAtsushi NiidaRyutaro UchiHidenari HirataHisateru KomatsuShotaro SakimuraShuto HayashiSho NambaraYosuke KurodaShuhei ItoHidetoshi EguchiTakaaki MasudaKeishi SugimachiTaro ToboHaruto NishidaTsutomu DaaKenichi ChibaYuichi ShiraishiTetsuichi YoshizatoMasaaki KodamaTadayoshi OkimotoKazuhiro MizukamiRyo OgawaKazuhisa OkamotoMitsutaka ShutoKensuke FukudaYusuke MatsuiTeppei ShimamuraTakanori HasegawaYuichiro DokiSatoshi NagayamaKazutaka YamadaMamoru KatoTatsuhiro ShibataMasaki MoriHiroyuki AburataniKazunari MurakamiYutaka SuzukiSeishi OgawaSatoru MiyanoKoshi MimoriNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tomoko Saito
Atsushi Niida
Ryutaro Uchi
Hidenari Hirata
Hisateru Komatsu
Shotaro Sakimura
Shuto Hayashi
Sho Nambara
Yosuke Kuroda
Shuhei Ito
Hidetoshi Eguchi
Takaaki Masuda
Keishi Sugimachi
Taro Tobo
Haruto Nishida
Tsutomu Daa
Kenichi Chiba
Yuichi Shiraishi
Tetsuichi Yoshizato
Masaaki Kodama
Tadayoshi Okimoto
Kazuhiro Mizukami
Ryo Ogawa
Kazuhisa Okamoto
Mitsutaka Shuto
Kensuke Fukuda
Yusuke Matsui
Teppei Shimamura
Takanori Hasegawa
Yuichiro Doki
Satoshi Nagayama
Kazutaka Yamada
Mamoru Kato
Tatsuhiro Shibata
Masaki Mori
Hiroyuki Aburatani
Kazunari Murakami
Yutaka Suzuki
Seishi Ogawa
Satoru Miyano
Koshi Mimori
A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer
description Advanced colorectal cancers are characterised by intra-tumour heterogeneity dictated by neutral evolution. Here the authors analyse early colorectal tumours by whole-exome sequencing and find that Darwinian evolution determines the fate of early lesions in colorectal adenoma and carcinoma in situ.
format article
author Tomoko Saito
Atsushi Niida
Ryutaro Uchi
Hidenari Hirata
Hisateru Komatsu
Shotaro Sakimura
Shuto Hayashi
Sho Nambara
Yosuke Kuroda
Shuhei Ito
Hidetoshi Eguchi
Takaaki Masuda
Keishi Sugimachi
Taro Tobo
Haruto Nishida
Tsutomu Daa
Kenichi Chiba
Yuichi Shiraishi
Tetsuichi Yoshizato
Masaaki Kodama
Tadayoshi Okimoto
Kazuhiro Mizukami
Ryo Ogawa
Kazuhisa Okamoto
Mitsutaka Shuto
Kensuke Fukuda
Yusuke Matsui
Teppei Shimamura
Takanori Hasegawa
Yuichiro Doki
Satoshi Nagayama
Kazutaka Yamada
Mamoru Kato
Tatsuhiro Shibata
Masaki Mori
Hiroyuki Aburatani
Kazunari Murakami
Yutaka Suzuki
Seishi Ogawa
Satoru Miyano
Koshi Mimori
author_facet Tomoko Saito
Atsushi Niida
Ryutaro Uchi
Hidenari Hirata
Hisateru Komatsu
Shotaro Sakimura
Shuto Hayashi
Sho Nambara
Yosuke Kuroda
Shuhei Ito
Hidetoshi Eguchi
Takaaki Masuda
Keishi Sugimachi
Taro Tobo
Haruto Nishida
Tsutomu Daa
Kenichi Chiba
Yuichi Shiraishi
Tetsuichi Yoshizato
Masaaki Kodama
Tadayoshi Okimoto
Kazuhiro Mizukami
Ryo Ogawa
Kazuhisa Okamoto
Mitsutaka Shuto
Kensuke Fukuda
Yusuke Matsui
Teppei Shimamura
Takanori Hasegawa
Yuichiro Doki
Satoshi Nagayama
Kazutaka Yamada
Mamoru Kato
Tatsuhiro Shibata
Masaki Mori
Hiroyuki Aburatani
Kazunari Murakami
Yutaka Suzuki
Seishi Ogawa
Satoru Miyano
Koshi Mimori
author_sort Tomoko Saito
title A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer
title_short A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer
title_full A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer
title_fullStr A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer
title_full_unstemmed A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer
title_sort temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/23dc0cb8e5fb48bfbd8d0dc7663ee372
work_keys_str_mv AT tomokosaito atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT atsushiniida atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT ryutarouchi atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT hidenarihirata atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT hisaterukomatsu atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT shotarosakimura atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT shutohayashi atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT shonambara atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT yosukekuroda atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT shuheiito atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT hidetoshieguchi atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT takaakimasuda atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT keishisugimachi atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT tarotobo atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT harutonishida atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT tsutomudaa atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kenichichiba atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT yuichishiraishi atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT tetsuichiyoshizato atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT masaakikodama atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT tadayoshiokimoto atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kazuhiromizukami atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT ryoogawa atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kazuhisaokamoto atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT mitsutakashuto atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kensukefukuda atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT yusukematsui atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT teppeishimamura atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT takanorihasegawa atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT yuichirodoki atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT satoshinagayama atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kazutakayamada atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT mamorukato atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT tatsuhiroshibata atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT masakimori atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT hiroyukiaburatani atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kazunarimurakami atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT yutakasuzuki atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT seishiogawa atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT satorumiyano atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT koshimimori atemporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT tomokosaito temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT atsushiniida temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT ryutarouchi temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT hidenarihirata temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT hisaterukomatsu temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT shotarosakimura temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT shutohayashi temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT shonambara temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT yosukekuroda temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT shuheiito temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT hidetoshieguchi temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT takaakimasuda temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT keishisugimachi temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT tarotobo temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT harutonishida temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT tsutomudaa temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kenichichiba temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT yuichishiraishi temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT tetsuichiyoshizato temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT masaakikodama temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT tadayoshiokimoto temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kazuhiromizukami temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT ryoogawa temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kazuhisaokamoto temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT mitsutakashuto temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kensukefukuda temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT yusukematsui temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT teppeishimamura temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT takanorihasegawa temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT yuichirodoki temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT satoshinagayama temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kazutakayamada temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT mamorukato temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT tatsuhiroshibata temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT masakimori temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT hiroyukiaburatani temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT kazunarimurakami temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT yutakasuzuki temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT seishiogawa temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT satorumiyano temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
AT koshimimori temporalshiftoftheevolutionaryprincipleshapingintratumorheterogeneityincolorectalcancer
_version_ 1718386949399511040

Ejemplares similares