Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice

Summary: We have shown that the improvement in hippocampal-based learning in aged mice following physical exercise observed is dependent on neurogenesis in the dentate gyrus (DG) and is regulated by changes in growth hormone levels. The changes in neurocircuitry, however, which may underlie this imp...

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Autores principales:	Xiaoqing Alice Zhou, Daniel G. Blackmore, Junjie Zhuo, Fatima A. Nasrallah, XuanVinh To, Nyoman D. Kurniawan, Alison Carlisle, King-Year Vien, Kai-Hsiang Chuang, Tianzi Jiang, Perry F. Bartlett
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	cognitive neuroscience Behavioral neuroscience Biological sciences Science Q
Acceso en línea:	https://doaj.org/article/23dd947aafc348e1bc3f60da55b6cfb4
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spelling	oai:doaj.org-article:23dd947aafc348e1bc3f60da55b6cfb42021-11-28T04:36:38ZNeurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice2589-004210.1016/j.isci.2021.103450https://doaj.org/article/23dd947aafc348e1bc3f60da55b6cfb42021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221014218https://doaj.org/toc/2589-0042Summary: We have shown that the improvement in hippocampal-based learning in aged mice following physical exercise observed is dependent on neurogenesis in the dentate gyrus (DG) and is regulated by changes in growth hormone levels. The changes in neurocircuitry, however, which may underlie this improvement, remain unclear. Using in vivo multimodal magnetic resonance imaging to track changes in aged mice exposed to exercise, we show the improved spatial learning is due to enhanced DG connectivity, particularly the strengthening of the DG-Cornu Ammonis 3 and the DG-medial entorhinal cortex connections in the dorsal hippocampus. Moreover, we provide evidence that these changes in circuitry are dependent on neurogenesis since they were abrogated by ablation of newborn neurons following exercise. These findings identify the specific changes in hippocampal circuitry that underlie the cognitive improvements resulting from physical activity and show that they are dependent on the activation of neurogenesis in aged animals.Xiaoqing Alice ZhouDaniel G. BlackmoreJunjie ZhuoFatima A. NasrallahXuanVinh ToNyoman D. KurniawanAlison CarlisleKing-Year VienKai-Hsiang ChuangTianzi JiangPerry F. BartlettElsevierarticlecognitive neuroscienceBehavioral neuroscienceBiological sciencesScienceQENiScience, Vol 24, Iss 12, Pp 103450- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognitive neuroscience Behavioral neuroscience Biological sciences Science Q
spellingShingle	cognitive neuroscience Behavioral neuroscience Biological sciences Science Q Xiaoqing Alice Zhou Daniel G. Blackmore Junjie Zhuo Fatima A. Nasrallah XuanVinh To Nyoman D. Kurniawan Alison Carlisle King-Year Vien Kai-Hsiang Chuang Tianzi Jiang Perry F. Bartlett Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice
description	Summary: We have shown that the improvement in hippocampal-based learning in aged mice following physical exercise observed is dependent on neurogenesis in the dentate gyrus (DG) and is regulated by changes in growth hormone levels. The changes in neurocircuitry, however, which may underlie this improvement, remain unclear. Using in vivo multimodal magnetic resonance imaging to track changes in aged mice exposed to exercise, we show the improved spatial learning is due to enhanced DG connectivity, particularly the strengthening of the DG-Cornu Ammonis 3 and the DG-medial entorhinal cortex connections in the dorsal hippocampus. Moreover, we provide evidence that these changes in circuitry are dependent on neurogenesis since they were abrogated by ablation of newborn neurons following exercise. These findings identify the specific changes in hippocampal circuitry that underlie the cognitive improvements resulting from physical activity and show that they are dependent on the activation of neurogenesis in aged animals.
format	article
author	Xiaoqing Alice Zhou Daniel G. Blackmore Junjie Zhuo Fatima A. Nasrallah XuanVinh To Nyoman D. Kurniawan Alison Carlisle King-Year Vien Kai-Hsiang Chuang Tianzi Jiang Perry F. Bartlett
author_facet	Xiaoqing Alice Zhou Daniel G. Blackmore Junjie Zhuo Fatima A. Nasrallah XuanVinh To Nyoman D. Kurniawan Alison Carlisle King-Year Vien Kai-Hsiang Chuang Tianzi Jiang Perry F. Bartlett
author_sort	Xiaoqing Alice Zhou
title	Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice
title_short	Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice
title_full	Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice
title_fullStr	Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice
title_full_unstemmed	Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice
title_sort	neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/23dd947aafc348e1bc3f60da55b6cfb4
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Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice

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