Characterization and Evaluation of Multiple Biological Activities of Silver Nanoparticles Fabricated from Dragon Tongue Bean Outer Peel Extract

Jayanta Kumar Patra,1 Han-Seung Shin,2 Gitishree Das1 1Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea; 2Department of Food Science and Biotechnology, Dongguk University‐Seoul, Gyeonggi‐do, 10326, Republic of Ko...

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Autores principales:	Patra JK, Shin HS, Das G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	antidiabetic antioxidant cytotoxicity legume peel silver nanoparticles green nano-synthesis. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/23dee775652844e4817b664263985cf5
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spelling	oai:doaj.org-article:23dee775652844e4817b664263985cf52021-12-02T13:50:52ZCharacterization and Evaluation of Multiple Biological Activities of Silver Nanoparticles Fabricated from Dragon Tongue Bean Outer Peel Extract1178-2013https://doaj.org/article/23dee775652844e4817b664263985cf52021-02-01T00:00:00Zhttps://www.dovepress.com/characterization-and-evaluation-of-multiple-biological-activities-of-s-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Jayanta Kumar Patra,1 Han-Seung Shin,2 Gitishree Das1 1Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea; 2Department of Food Science and Biotechnology, Dongguk University‐Seoul, Gyeonggi‐do, 10326, Republic of KoreaCorrespondence: Gitishree DasResearch Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of KoreaEmail gitishreedas@gmail.comBackground: The dragon tongue beans are a legume belonging to the Fabaceae family, are rich in protein, starch, fiber, and other micronutrients that have numerous health-promoting benefits. Its peel commonly the waste parts also contains lots of bioactive compounds.Materials and Methods: In the current research, dragon tongue bean peels (DtbP) extract is tested for the existence of phytochemicals. Ag nanoparticles are biosynthesized using DtbP extract. The generated DtbP silver nanoparticle characterization was accomplished using UV-Vis spectral analysis, FTIR spectral analysis, SEM analysis, EDX analysis, XRD analysis, zeta potential, and DLS study. Furthermore, comparative assessment on multi-biological activities of the biosynthesized Ag nanoparticles was accomplished by employing cytotoxicity (inhibition against HepG2 cancer cells), antidiabetic (α-glucosidase inhibition assay), and antioxidant (free-radical scavenging) analysis.Results: The characterization result of the DtbP-AgNPs demonstrated that the AgNPs synthesized within 24 h. The AgNPs are nearly spherical. The biological effect assay of AgNPs displayed that DtbP-AgNPs is having significant cytotoxicity, antidiabetic, and moderate antioxidant effect. This study results as a whole report the biosynthesis of DtbP-AgNPs utilizing the legume dragon tongue bean waste peel and assessment of their multiple biological activities. The synthesized DtbP-AgNPs could serve as a potential candidate in the pharmaceutical industries in the formulation of drugs for the treatment of several medical ailments concerning cancer, diabetes, etc.Keywords: antidiabetic, antioxidant, cytotoxicity, legume peel, silver nanoparticles, green nano-synthesisPatra JKShin HSDas GDove Medical Pressarticleantidiabeticantioxidantcytotoxicitylegume peelsilver nanoparticlesgreen nano-synthesis.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 977-987 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antidiabetic antioxidant cytotoxicity legume peel silver nanoparticles green nano-synthesis. Medicine (General) R5-920
spellingShingle	antidiabetic antioxidant cytotoxicity legume peel silver nanoparticles green nano-synthesis. Medicine (General) R5-920 Patra JK Shin HS Das G Characterization and Evaluation of Multiple Biological Activities of Silver Nanoparticles Fabricated from Dragon Tongue Bean Outer Peel Extract
description	Jayanta Kumar Patra,1 Han-Seung Shin,2 Gitishree Das1 1Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea; 2Department of Food Science and Biotechnology, Dongguk University‐Seoul, Gyeonggi‐do, 10326, Republic of KoreaCorrespondence: Gitishree DasResearch Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of KoreaEmail gitishreedas@gmail.comBackground: The dragon tongue beans are a legume belonging to the Fabaceae family, are rich in protein, starch, fiber, and other micronutrients that have numerous health-promoting benefits. Its peel commonly the waste parts also contains lots of bioactive compounds.Materials and Methods: In the current research, dragon tongue bean peels (DtbP) extract is tested for the existence of phytochemicals. Ag nanoparticles are biosynthesized using DtbP extract. The generated DtbP silver nanoparticle characterization was accomplished using UV-Vis spectral analysis, FTIR spectral analysis, SEM analysis, EDX analysis, XRD analysis, zeta potential, and DLS study. Furthermore, comparative assessment on multi-biological activities of the biosynthesized Ag nanoparticles was accomplished by employing cytotoxicity (inhibition against HepG2 cancer cells), antidiabetic (α-glucosidase inhibition assay), and antioxidant (free-radical scavenging) analysis.Results: The characterization result of the DtbP-AgNPs demonstrated that the AgNPs synthesized within 24 h. The AgNPs are nearly spherical. The biological effect assay of AgNPs displayed that DtbP-AgNPs is having significant cytotoxicity, antidiabetic, and moderate antioxidant effect. This study results as a whole report the biosynthesis of DtbP-AgNPs utilizing the legume dragon tongue bean waste peel and assessment of their multiple biological activities. The synthesized DtbP-AgNPs could serve as a potential candidate in the pharmaceutical industries in the formulation of drugs for the treatment of several medical ailments concerning cancer, diabetes, etc.Keywords: antidiabetic, antioxidant, cytotoxicity, legume peel, silver nanoparticles, green nano-synthesis
format	article
author	Patra JK Shin HS Das G
author_facet	Patra JK Shin HS Das G
author_sort	Patra JK
title	Characterization and Evaluation of Multiple Biological Activities of Silver Nanoparticles Fabricated from Dragon Tongue Bean Outer Peel Extract
title_short	Characterization and Evaluation of Multiple Biological Activities of Silver Nanoparticles Fabricated from Dragon Tongue Bean Outer Peel Extract
title_full	Characterization and Evaluation of Multiple Biological Activities of Silver Nanoparticles Fabricated from Dragon Tongue Bean Outer Peel Extract
title_fullStr	Characterization and Evaluation of Multiple Biological Activities of Silver Nanoparticles Fabricated from Dragon Tongue Bean Outer Peel Extract
title_full_unstemmed	Characterization and Evaluation of Multiple Biological Activities of Silver Nanoparticles Fabricated from Dragon Tongue Bean Outer Peel Extract
title_sort	characterization and evaluation of multiple biological activities of silver nanoparticles fabricated from dragon tongue bean outer peel extract
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/23dee775652844e4817b664263985cf5
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Characterization and Evaluation of Multiple Biological Activities of Silver Nanoparticles Fabricated from Dragon Tongue Bean Outer Peel Extract

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