Establishing microbial composition measurement standards with reference frames

Most microbiome studies make conclusions based on changes in relative abundance of taxa, inferred from sequencing data. Here, the authors highlight common pitfalls in comparing relative abundance across samples, and identify solutions that reveal microbial changes without the need to estimate total...

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Autores principales:	James T. Morton, Clarisse Marotz, Alex Washburne, Justin Silverman, Livia S. Zaramela, Anna Edlund, Karsten Zengler, Rob Knight
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/23e13887be754c6794e21478d47ef59f
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spelling	oai:doaj.org-article:23e13887be754c6794e21478d47ef59f2021-12-02T15:35:49ZEstablishing microbial composition measurement standards with reference frames10.1038/s41467-019-10656-52041-1723https://doaj.org/article/23e13887be754c6794e21478d47ef59f2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10656-5https://doaj.org/toc/2041-1723Most microbiome studies make conclusions based on changes in relative abundance of taxa, inferred from sequencing data. Here, the authors highlight common pitfalls in comparing relative abundance across samples, and identify solutions that reveal microbial changes without the need to estimate total microbial load.James T. MortonClarisse MarotzAlex WashburneJustin SilvermanLivia S. ZaramelaAnna EdlundKarsten ZenglerRob KnightNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q James T. Morton Clarisse Marotz Alex Washburne Justin Silverman Livia S. Zaramela Anna Edlund Karsten Zengler Rob Knight Establishing microbial composition measurement standards with reference frames
description	Most microbiome studies make conclusions based on changes in relative abundance of taxa, inferred from sequencing data. Here, the authors highlight common pitfalls in comparing relative abundance across samples, and identify solutions that reveal microbial changes without the need to estimate total microbial load.
format	article
author	James T. Morton Clarisse Marotz Alex Washburne Justin Silverman Livia S. Zaramela Anna Edlund Karsten Zengler Rob Knight
author_facet	James T. Morton Clarisse Marotz Alex Washburne Justin Silverman Livia S. Zaramela Anna Edlund Karsten Zengler Rob Knight
author_sort	James T. Morton
title	Establishing microbial composition measurement standards with reference frames
title_short	Establishing microbial composition measurement standards with reference frames
title_full	Establishing microbial composition measurement standards with reference frames
title_fullStr	Establishing microbial composition measurement standards with reference frames
title_full_unstemmed	Establishing microbial composition measurement standards with reference frames
title_sort	establishing microbial composition measurement standards with reference frames
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/23e13887be754c6794e21478d47ef59f
work_keys_str_mv	AT jamestmorton establishingmicrobialcompositionmeasurementstandardswithreferenceframes AT clarissemarotz establishingmicrobialcompositionmeasurementstandardswithreferenceframes AT alexwashburne establishingmicrobialcompositionmeasurementstandardswithreferenceframes AT justinsilverman establishingmicrobialcompositionmeasurementstandardswithreferenceframes AT liviaszaramela establishingmicrobialcompositionmeasurementstandardswithreferenceframes AT annaedlund establishingmicrobialcompositionmeasurementstandardswithreferenceframes AT karstenzengler establishingmicrobialcompositionmeasurementstandardswithreferenceframes AT robknight establishingmicrobialcompositionmeasurementstandardswithreferenceframes
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Establishing microbial composition measurement standards with reference frames

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