Bone mass and the CAG and GGN androgen receptor polymorphisms in young men.

<h4>Background</h4>To determine whether androgen receptor (AR) CAG (polyglutamine) and GGN (polyglycine) polymorphisms influence bone mineral density (BMD), osteocalcin and free serum testosterone concentration in young men.<h4>Methodology/principal findings</h4>Whole body, l...

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Autores principales:	Amelia Guadalupe-Grau, Francisco Germán Rodríguez-González, Jesús Gustavo Ponce-González, Cecilia Dorado, Hugo Olmedillas, Teresa Fuentes, Jorge Pérez-Gómez, Joaquín Sanchís-Moysi, Bonifacio Nicolás Díaz-Chico, José A L Calbet
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23e46805ed37406d9daffe5e2fd254f4
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spelling	oai:doaj.org-article:23e46805ed37406d9daffe5e2fd254f42021-12-02T20:20:10ZBone mass and the CAG and GGN androgen receptor polymorphisms in young men.1932-620310.1371/journal.pone.0011529https://doaj.org/article/23e46805ed37406d9daffe5e2fd254f42010-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20634949/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To determine whether androgen receptor (AR) CAG (polyglutamine) and GGN (polyglycine) polymorphisms influence bone mineral density (BMD), osteocalcin and free serum testosterone concentration in young men.<h4>Methodology/principal findings</h4>Whole body, lumbar spine and femoral bone mineral content (BMC) and BMD, Dual X-ray Absorptiometry (DXA), AR repeat polymorphisms (PCR), osteocalcin and free testosterone (ELISA) were determined in 282 healthy men (28.6+/-7.6 years). Individuals were grouped as CAG short (CAG(S)) if harboring repeat lengths of < or = 21 or CAG long (CAG(L)) if CAG > 21, and GGN was considered short (GGN(S)) or long (GGN(L)) if GGN < or = 23 or > 23. There was an inverse association between logarithm of CAG and GGN length and Ward's Triangle BMC (r = -0.15 and -0.15, P<0.05, age and height adjusted). No associations between CAG or GGN repeat length and regional BMC or BMD were observed after adjusting for age. Whole body and regional BMC and BMD values were similar in men harboring CAG(S), CAG(L), GGN(S) or GGN(L) AR repeat polymorphisms. Men harboring the combination CAG(L)+GGN(L) had 6.3 and 4.4% higher lumbar spine BMC and BMD than men with the haplotype CAG(S)+GGN(S) (both P<0.05). Femoral neck BMD was 4.8% higher in the CAG(S)+GGN(S) compared with the CAG(L)+GGN(S) men (P<0.05). CAG(S), CAG(L), GGN(S), GGN(L) men had similar osteocalcin concentration as well as the four CAG-GGN haplotypes studied.<h4>Conclusion</h4>AR polymorphisms have an influence on BMC and BMD in healthy adult humans, which cannot be explained through effects in osteoblastic activity.Amelia Guadalupe-GrauFrancisco Germán Rodríguez-GonzálezJesús Gustavo Ponce-GonzálezCecilia DoradoHugo OlmedillasTeresa FuentesJorge Pérez-GómezJoaquín Sanchís-MoysiBonifacio Nicolás Díaz-ChicoJosé A L CalbetPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 7, p e11529 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amelia Guadalupe-Grau Francisco Germán Rodríguez-González Jesús Gustavo Ponce-González Cecilia Dorado Hugo Olmedillas Teresa Fuentes Jorge Pérez-Gómez Joaquín Sanchís-Moysi Bonifacio Nicolás Díaz-Chico José A L Calbet Bone mass and the CAG and GGN androgen receptor polymorphisms in young men.
description	<h4>Background</h4>To determine whether androgen receptor (AR) CAG (polyglutamine) and GGN (polyglycine) polymorphisms influence bone mineral density (BMD), osteocalcin and free serum testosterone concentration in young men.<h4>Methodology/principal findings</h4>Whole body, lumbar spine and femoral bone mineral content (BMC) and BMD, Dual X-ray Absorptiometry (DXA), AR repeat polymorphisms (PCR), osteocalcin and free testosterone (ELISA) were determined in 282 healthy men (28.6+/-7.6 years). Individuals were grouped as CAG short (CAG(S)) if harboring repeat lengths of < or = 21 or CAG long (CAG(L)) if CAG > 21, and GGN was considered short (GGN(S)) or long (GGN(L)) if GGN < or = 23 or > 23. There was an inverse association between logarithm of CAG and GGN length and Ward's Triangle BMC (r = -0.15 and -0.15, P<0.05, age and height adjusted). No associations between CAG or GGN repeat length and regional BMC or BMD were observed after adjusting for age. Whole body and regional BMC and BMD values were similar in men harboring CAG(S), CAG(L), GGN(S) or GGN(L) AR repeat polymorphisms. Men harboring the combination CAG(L)+GGN(L) had 6.3 and 4.4% higher lumbar spine BMC and BMD than men with the haplotype CAG(S)+GGN(S) (both P<0.05). Femoral neck BMD was 4.8% higher in the CAG(S)+GGN(S) compared with the CAG(L)+GGN(S) men (P<0.05). CAG(S), CAG(L), GGN(S), GGN(L) men had similar osteocalcin concentration as well as the four CAG-GGN haplotypes studied.<h4>Conclusion</h4>AR polymorphisms have an influence on BMC and BMD in healthy adult humans, which cannot be explained through effects in osteoblastic activity.
format	article
author	Amelia Guadalupe-Grau Francisco Germán Rodríguez-González Jesús Gustavo Ponce-González Cecilia Dorado Hugo Olmedillas Teresa Fuentes Jorge Pérez-Gómez Joaquín Sanchís-Moysi Bonifacio Nicolás Díaz-Chico José A L Calbet
author_facet	Amelia Guadalupe-Grau Francisco Germán Rodríguez-González Jesús Gustavo Ponce-González Cecilia Dorado Hugo Olmedillas Teresa Fuentes Jorge Pérez-Gómez Joaquín Sanchís-Moysi Bonifacio Nicolás Díaz-Chico José A L Calbet
author_sort	Amelia Guadalupe-Grau
title	Bone mass and the CAG and GGN androgen receptor polymorphisms in young men.
title_short	Bone mass and the CAG and GGN androgen receptor polymorphisms in young men.
title_full	Bone mass and the CAG and GGN androgen receptor polymorphisms in young men.
title_fullStr	Bone mass and the CAG and GGN androgen receptor polymorphisms in young men.
title_full_unstemmed	Bone mass and the CAG and GGN androgen receptor polymorphisms in young men.
title_sort	bone mass and the cag and ggn androgen receptor polymorphisms in young men.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/23e46805ed37406d9daffe5e2fd254f4
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Bone mass and the CAG and GGN androgen receptor polymorphisms in young men.

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