Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural ant...

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Autores principales:	Mei Zhang, Xiaolin Zhang, Taoran Tian, Qi Zhang, Yuting Wen, Junyao Zhu, Dexuan Xiao, Weitong Cui, Yunfeng Lin
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Tetrahedral framework DNA nanoparticle Oxidative stress NF-κB signaling pathway Macrophage Gouty arthritis Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/23e766c1348545f3a0da91a31e494e7c
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spelling	oai:doaj.org-article:23e766c1348545f3a0da91a31e494e7c2021-11-04T04:34:52ZAnti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis2452-199X10.1016/j.bioactmat.2021.06.003https://doaj.org/article/23e766c1348545f3a0da91a31e494e7c2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21002863https://doaj.org/toc/2452-199XGouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural anti-inflammatory drug, has demonstrated good safety and efficacy. However, the rapid degradation, poor aqueous solubility, and low bioavailability of Cur limit its therapeutic effect. To strengthen the effectiveness and bioavailability of Cur. Cur loaded tetrahedral framework nucleic acids (Cur-TFNAs) were synthesized to deliver Cur. Compared with free Cur, Cur-TFNAs exhibit a preferable drug stability, good biocompatibility (CCK-8 assay), ease of uptake (immunofluorescence), and higher tissue utilization (in vivo biodistribution). Most importantly, Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression. Therefore, we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases.Mei ZhangXiaolin ZhangTaoran TianQi ZhangYuting WenJunyao ZhuDexuan XiaoWeitong CuiYunfeng LinKeAi Communications Co., Ltd.articleTetrahedral framework DNA nanoparticleOxidative stressNF-κB signaling pathwayMacrophageGouty arthritisMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 368-380 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Tetrahedral framework DNA nanoparticle Oxidative stress NF-κB signaling pathway Macrophage Gouty arthritis Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Tetrahedral framework DNA nanoparticle Oxidative stress NF-κB signaling pathway Macrophage Gouty arthritis Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Mei Zhang Xiaolin Zhang Taoran Tian Qi Zhang Yuting Wen Junyao Zhu Dexuan Xiao Weitong Cui Yunfeng Lin Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis
description	Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural anti-inflammatory drug, has demonstrated good safety and efficacy. However, the rapid degradation, poor aqueous solubility, and low bioavailability of Cur limit its therapeutic effect. To strengthen the effectiveness and bioavailability of Cur. Cur loaded tetrahedral framework nucleic acids (Cur-TFNAs) were synthesized to deliver Cur. Compared with free Cur, Cur-TFNAs exhibit a preferable drug stability, good biocompatibility (CCK-8 assay), ease of uptake (immunofluorescence), and higher tissue utilization (in vivo biodistribution). Most importantly, Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression. Therefore, we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases.
format	article
author	Mei Zhang Xiaolin Zhang Taoran Tian Qi Zhang Yuting Wen Junyao Zhu Dexuan Xiao Weitong Cui Yunfeng Lin
author_facet	Mei Zhang Xiaolin Zhang Taoran Tian Qi Zhang Yuting Wen Junyao Zhu Dexuan Xiao Weitong Cui Yunfeng Lin
author_sort	Mei Zhang
title	Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis
title_short	Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis
title_full	Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis
title_fullStr	Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis
title_full_unstemmed	Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis
title_sort	anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/23e766c1348545f3a0da91a31e494e7c
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Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

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