Selective breeding for a behavioral trait changes digit ratio.

The ratio of the length of the second digit (index finger) divided by the fourth digit (ring finger) tends to be lower in men than in women. This 2D:4D digit ratio is often used as a proxy for prenatal androgen exposure in studies of human health and behavior. For example, 2D:4D ratio is lower (i.e....

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Autores principales:	Reginia H Y Yan, Jessica L Malisch, Robert M Hannon, Peter L Hurd, Theodore Garland
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23ef78e4a29341d4b436a032ebc30b93
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spelling	oai:doaj.org-article:23ef78e4a29341d4b436a032ebc30b932021-11-25T06:18:35ZSelective breeding for a behavioral trait changes digit ratio.1932-620310.1371/journal.pone.0003216https://doaj.org/article/23ef78e4a29341d4b436a032ebc30b932008-09-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18797502/?tool=EBIhttps://doaj.org/toc/1932-6203The ratio of the length of the second digit (index finger) divided by the fourth digit (ring finger) tends to be lower in men than in women. This 2D:4D digit ratio is often used as a proxy for prenatal androgen exposure in studies of human health and behavior. For example, 2D:4D ratio is lower (i.e. more "masculinized") in both men and women of greater physical fitness and/or sporting ability. Lab mice have also shown variation in 2D:4D as a function of uterine environment, and mouse digit ratios seem also to correlate with behavioral traits, including daily activity levels. Selective breeding for increased rates of voluntary exercise (wheel running) in four lines of mice has caused correlated increases in aerobic exercise capacity, circulating corticosterone level, and predatory aggression. Here, we show that this selection regime has also increased 2D:4D. This apparent "feminization" in mice is opposite to the relationship seen between 2D:4D and physical fitness in human beings. The present results are difficult to reconcile with the notion that 2D:4D is an effective proxy for prenatal androgen exposure; instead, it may more accurately reflect effects of glucocorticoids, or other factors that regulate any of many genes.Reginia H Y YanJessica L MalischRobert M HannonPeter L HurdTheodore GarlandPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 9, p e3216 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Reginia H Y Yan Jessica L Malisch Robert M Hannon Peter L Hurd Theodore Garland Selective breeding for a behavioral trait changes digit ratio.
description	The ratio of the length of the second digit (index finger) divided by the fourth digit (ring finger) tends to be lower in men than in women. This 2D:4D digit ratio is often used as a proxy for prenatal androgen exposure in studies of human health and behavior. For example, 2D:4D ratio is lower (i.e. more "masculinized") in both men and women of greater physical fitness and/or sporting ability. Lab mice have also shown variation in 2D:4D as a function of uterine environment, and mouse digit ratios seem also to correlate with behavioral traits, including daily activity levels. Selective breeding for increased rates of voluntary exercise (wheel running) in four lines of mice has caused correlated increases in aerobic exercise capacity, circulating corticosterone level, and predatory aggression. Here, we show that this selection regime has also increased 2D:4D. This apparent "feminization" in mice is opposite to the relationship seen between 2D:4D and physical fitness in human beings. The present results are difficult to reconcile with the notion that 2D:4D is an effective proxy for prenatal androgen exposure; instead, it may more accurately reflect effects of glucocorticoids, or other factors that regulate any of many genes.
format	article
author	Reginia H Y Yan Jessica L Malisch Robert M Hannon Peter L Hurd Theodore Garland
author_facet	Reginia H Y Yan Jessica L Malisch Robert M Hannon Peter L Hurd Theodore Garland
author_sort	Reginia H Y Yan
title	Selective breeding for a behavioral trait changes digit ratio.
title_short	Selective breeding for a behavioral trait changes digit ratio.
title_full	Selective breeding for a behavioral trait changes digit ratio.
title_fullStr	Selective breeding for a behavioral trait changes digit ratio.
title_full_unstemmed	Selective breeding for a behavioral trait changes digit ratio.
title_sort	selective breeding for a behavioral trait changes digit ratio.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/23ef78e4a29341d4b436a032ebc30b93
work_keys_str_mv	AT reginiahyyan selectivebreedingforabehavioraltraitchangesdigitratio AT jessicalmalisch selectivebreedingforabehavioraltraitchangesdigitratio AT robertmhannon selectivebreedingforabehavioraltraitchangesdigitratio AT peterlhurd selectivebreedingforabehavioraltraitchangesdigitratio AT theodoregarland selectivebreedingforabehavioraltraitchangesdigitratio
_version_	1718413911887183872

Selective breeding for a behavioral trait changes digit ratio.

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