Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

Polyphenols have partial antidepressant effect without known mechanism. Here, the authors identify two phytochemicals from bioactive dietary polyphenols, show their antidepressant effect in a rodent model of depression, and that this effect is mediated by epigenetic and anti-inflammatory mechanisms.

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Detalles Bibliográficos
Autores principales: Jun Wang, Georgia E. Hodes, Hongxing Zhang, Song Zhang, Wei Zhao, Sam A. Golden, Weina Bi, Caroline Menard, Veronika Kana, Marylene Leboeuf, Marc Xie, Dana Bregman, Madeline L. Pfau, Meghan E. Flanigan, Adelaida Esteban-Fernández, Shrishailam Yemul, Ali Sharma, Lap Ho, Richard Dixon, Miriam Merad, Ming-Hu Han, Scott J. Russo, Giulio M. Pasinetti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/23f3bdbf01a249bd99070c55d3345edc
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Descripción
Sumario:Polyphenols have partial antidepressant effect without known mechanism. Here, the authors identify two phytochemicals from bioactive dietary polyphenols, show their antidepressant effect in a rodent model of depression, and that this effect is mediated by epigenetic and anti-inflammatory mechanisms.

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