Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

Polyphenols have partial antidepressant effect without known mechanism. Here, the authors identify two phytochemicals from bioactive dietary polyphenols, show their antidepressant effect in a rodent model of depression, and that this effect is mediated by epigenetic and anti-inflammatory mechanisms.

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Autores principales:	Jun Wang, Georgia E. Hodes, Hongxing Zhang, Song Zhang, Wei Zhao, Sam A. Golden, Weina Bi, Caroline Menard, Veronika Kana, Marylene Leboeuf, Marc Xie, Dana Bregman, Madeline L. Pfau, Meghan E. Flanigan, Adelaida Esteban-Fernández, Shrishailam Yemul, Ali Sharma, Lap Ho, Richard Dixon, Miriam Merad, Ming-Hu Han, Scott J. Russo, Giulio M. Pasinetti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/23f3bdbf01a249bd99070c55d3345edc
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spelling	oai:doaj.org-article:23f3bdbf01a249bd99070c55d3345edc2021-12-02T15:34:24ZEpigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice10.1038/s41467-017-02794-52041-1723https://doaj.org/article/23f3bdbf01a249bd99070c55d3345edc2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02794-5https://doaj.org/toc/2041-1723Polyphenols have partial antidepressant effect without known mechanism. Here, the authors identify two phytochemicals from bioactive dietary polyphenols, show their antidepressant effect in a rodent model of depression, and that this effect is mediated by epigenetic and anti-inflammatory mechanisms.Jun WangGeorgia E. HodesHongxing ZhangSong ZhangWei ZhaoSam A. GoldenWeina BiCaroline MenardVeronika KanaMarylene LeboeufMarc XieDana BregmanMadeline L. PfauMeghan E. FlaniganAdelaida Esteban-FernándezShrishailam YemulAli SharmaLap HoRichard DixonMiriam MeradMing-Hu HanScott J. RussoGiulio M. PasinettiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jun Wang Georgia E. Hodes Hongxing Zhang Song Zhang Wei Zhao Sam A. Golden Weina Bi Caroline Menard Veronika Kana Marylene Leboeuf Marc Xie Dana Bregman Madeline L. Pfau Meghan E. Flanigan Adelaida Esteban-Fernández Shrishailam Yemul Ali Sharma Lap Ho Richard Dixon Miriam Merad Ming-Hu Han Scott J. Russo Giulio M. Pasinetti Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
description	Polyphenols have partial antidepressant effect without known mechanism. Here, the authors identify two phytochemicals from bioactive dietary polyphenols, show their antidepressant effect in a rodent model of depression, and that this effect is mediated by epigenetic and anti-inflammatory mechanisms.
format	article
author	Jun Wang Georgia E. Hodes Hongxing Zhang Song Zhang Wei Zhao Sam A. Golden Weina Bi Caroline Menard Veronika Kana Marylene Leboeuf Marc Xie Dana Bregman Madeline L. Pfau Meghan E. Flanigan Adelaida Esteban-Fernández Shrishailam Yemul Ali Sharma Lap Ho Richard Dixon Miriam Merad Ming-Hu Han Scott J. Russo Giulio M. Pasinetti
author_facet	Jun Wang Georgia E. Hodes Hongxing Zhang Song Zhang Wei Zhao Sam A. Golden Weina Bi Caroline Menard Veronika Kana Marylene Leboeuf Marc Xie Dana Bregman Madeline L. Pfau Meghan E. Flanigan Adelaida Esteban-Fernández Shrishailam Yemul Ali Sharma Lap Ho Richard Dixon Miriam Merad Ming-Hu Han Scott J. Russo Giulio M. Pasinetti
author_sort	Jun Wang
title	Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
title_short	Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
title_full	Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
title_fullStr	Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
title_full_unstemmed	Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
title_sort	epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/23f3bdbf01a249bd99070c55d3345edc
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_version_	1718386827298078720

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

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