Prognostic factors in elderly patients with T1 glottic cancer treated with radiotherapy

Abstract The aim of the study was the evaluation of the effectiveness of radiotherapy in elderly T1 glottic cancer patients and prognostic factors with particular focus on comorbidities. Five-year overall survival, disease-specific survival, and local control rates were 63%, 92%, and 93%, respective...

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Autores principales:	Anna Mucha-Małecka, Krzysztof Małecki, Natalia Amrogowicz, Beata Biesaga, Maciej Modrzejewski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23f5a63f3b0d47d28da6cd64dee226ed
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spelling	oai:doaj.org-article:23f5a63f3b0d47d28da6cd64dee226ed2021-12-02T19:12:27ZPrognostic factors in elderly patients with T1 glottic cancer treated with radiotherapy10.1038/s41598-021-96146-52045-2322https://doaj.org/article/23f5a63f3b0d47d28da6cd64dee226ed2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96146-5https://doaj.org/toc/2045-2322Abstract The aim of the study was the evaluation of the effectiveness of radiotherapy in elderly T1 glottic cancer patients and prognostic factors with particular focus on comorbidities. Five-year overall survival, disease-specific survival, and local control rates were 63%, 92%, and 93%, respectively. Multivariate analysis showed that the following factors had statistically significant impact on local relapse risk and cancer death risk: diabetes, underweight, and fraction dose of 2 Gy. High number of comorbidities, high CCI, and underweight negatively influenced overall survival. A retrospective analysis was performed in a group of 131 T1N0M0 glottic cancer patients aged 70 and above treated with irradiation at the National Institute of Oncology in Cracow between 1977 and 2007. In the analyzed group men prevailed (92%) of mean age of 74 years. Each patient was diagnosed with at least one comorbidity with the following comorbid conditions being most frequent: hypertension, ischemic heart disease, and chronic obstructive pulmonary disease. In the studied group, the effect of comorbidities on overall survival was evaluated using Charlson Comorbidity Index (CCI). Twenty five (19%) patients showed underweight. All patients were irradiated once daily, 5 days a week, to a total dose of 60–70 Gy with a fraction dose of 2 or 2.5 Gy. Radiotherapy is an effective treatment modality in elderly T1 glottic cancer patients. Diabetes as comorbidity, underweight, and conventional dose fractionation decrease the probability of curative effect of radiotherapy in this group of patients, while high number of comorbidities diminishes the probability of long-term survival.Anna Mucha-MałeckaKrzysztof MałeckiNatalia AmrogowiczBeata BiesagaMaciej ModrzejewskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna Mucha-Małecka Krzysztof Małecki Natalia Amrogowicz Beata Biesaga Maciej Modrzejewski Prognostic factors in elderly patients with T1 glottic cancer treated with radiotherapy
description	Abstract The aim of the study was the evaluation of the effectiveness of radiotherapy in elderly T1 glottic cancer patients and prognostic factors with particular focus on comorbidities. Five-year overall survival, disease-specific survival, and local control rates were 63%, 92%, and 93%, respectively. Multivariate analysis showed that the following factors had statistically significant impact on local relapse risk and cancer death risk: diabetes, underweight, and fraction dose of 2 Gy. High number of comorbidities, high CCI, and underweight negatively influenced overall survival. A retrospective analysis was performed in a group of 131 T1N0M0 glottic cancer patients aged 70 and above treated with irradiation at the National Institute of Oncology in Cracow between 1977 and 2007. In the analyzed group men prevailed (92%) of mean age of 74 years. Each patient was diagnosed with at least one comorbidity with the following comorbid conditions being most frequent: hypertension, ischemic heart disease, and chronic obstructive pulmonary disease. In the studied group, the effect of comorbidities on overall survival was evaluated using Charlson Comorbidity Index (CCI). Twenty five (19%) patients showed underweight. All patients were irradiated once daily, 5 days a week, to a total dose of 60–70 Gy with a fraction dose of 2 or 2.5 Gy. Radiotherapy is an effective treatment modality in elderly T1 glottic cancer patients. Diabetes as comorbidity, underweight, and conventional dose fractionation decrease the probability of curative effect of radiotherapy in this group of patients, while high number of comorbidities diminishes the probability of long-term survival.
format	article
author	Anna Mucha-Małecka Krzysztof Małecki Natalia Amrogowicz Beata Biesaga Maciej Modrzejewski
author_facet	Anna Mucha-Małecka Krzysztof Małecki Natalia Amrogowicz Beata Biesaga Maciej Modrzejewski
author_sort	Anna Mucha-Małecka
title	Prognostic factors in elderly patients with T1 glottic cancer treated with radiotherapy
title_short	Prognostic factors in elderly patients with T1 glottic cancer treated with radiotherapy
title_full	Prognostic factors in elderly patients with T1 glottic cancer treated with radiotherapy
title_fullStr	Prognostic factors in elderly patients with T1 glottic cancer treated with radiotherapy
title_full_unstemmed	Prognostic factors in elderly patients with T1 glottic cancer treated with radiotherapy
title_sort	prognostic factors in elderly patients with t1 glottic cancer treated with radiotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/23f5a63f3b0d47d28da6cd64dee226ed
work_keys_str_mv	AT annamuchamałecka prognosticfactorsinelderlypatientswitht1glotticcancertreatedwithradiotherapy AT krzysztofmałecki prognosticfactorsinelderlypatientswitht1glotticcancertreatedwithradiotherapy AT nataliaamrogowicz prognosticfactorsinelderlypatientswitht1glotticcancertreatedwithradiotherapy AT beatabiesaga prognosticfactorsinelderlypatientswitht1glotticcancertreatedwithradiotherapy AT maciejmodrzejewski prognosticfactorsinelderlypatientswitht1glotticcancertreatedwithradiotherapy
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Prognostic factors in elderly patients with T1 glottic cancer treated with radiotherapy

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