Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia

Loss of function mutations of NSD1 occur in blood cancers. Here, the authors report that NSD1 loss blocks erythroid differentiation which leads to an erythroleukemia-like disease in mice by impairing GATA1-induced target gene activation.

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Autores principales:	Katharina Leonards, Marwa Almosailleakh, Samantha Tauchmann, Frederik Otzen Bagger, Cécile Thirant, Sabine Juge, Thomas Bock, Hélène Méreau, Matheus F. Bezerra, Alexandar Tzankov, Robert Ivanek, Régine Losson, Antoine H. F. M. Peters, Thomas Mercher, Juerg Schwaller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/23f6a9ca034c46419734966b67ed3c71
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spelling	oai:doaj.org-article:23f6a9ca034c46419734966b67ed3c712021-12-02T17:34:30ZNuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia10.1038/s41467-020-16179-82041-1723https://doaj.org/article/23f6a9ca034c46419734966b67ed3c712020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16179-8https://doaj.org/toc/2041-1723Loss of function mutations of NSD1 occur in blood cancers. Here, the authors report that NSD1 loss blocks erythroid differentiation which leads to an erythroleukemia-like disease in mice by impairing GATA1-induced target gene activation.Katharina LeonardsMarwa AlmosailleakhSamantha TauchmannFrederik Otzen BaggerCécile ThirantSabine JugeThomas BockHélène MéreauMatheus F. BezerraAlexandar TzankovRobert IvanekRégine LossonAntoine H. F. M. PetersThomas MercherJuerg SchwallerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katharina Leonards Marwa Almosailleakh Samantha Tauchmann Frederik Otzen Bagger Cécile Thirant Sabine Juge Thomas Bock Hélène Méreau Matheus F. Bezerra Alexandar Tzankov Robert Ivanek Régine Losson Antoine H. F. M. Peters Thomas Mercher Juerg Schwaller Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia
description	Loss of function mutations of NSD1 occur in blood cancers. Here, the authors report that NSD1 loss blocks erythroid differentiation which leads to an erythroleukemia-like disease in mice by impairing GATA1-induced target gene activation.
format	article
author	Katharina Leonards Marwa Almosailleakh Samantha Tauchmann Frederik Otzen Bagger Cécile Thirant Sabine Juge Thomas Bock Hélène Méreau Matheus F. Bezerra Alexandar Tzankov Robert Ivanek Régine Losson Antoine H. F. M. Peters Thomas Mercher Juerg Schwaller
author_facet	Katharina Leonards Marwa Almosailleakh Samantha Tauchmann Frederik Otzen Bagger Cécile Thirant Sabine Juge Thomas Bock Hélène Méreau Matheus F. Bezerra Alexandar Tzankov Robert Ivanek Régine Losson Antoine H. F. M. Peters Thomas Mercher Juerg Schwaller
author_sort	Katharina Leonards
title	Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia
title_short	Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia
title_full	Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia
title_fullStr	Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia
title_full_unstemmed	Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia
title_sort	nuclear interacting set domain protein 1 inactivation impairs gata1-regulated erythroid differentiation and causes erythroleukemia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/23f6a9ca034c46419734966b67ed3c71
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Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia

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