Behavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila.

Gustatory stimuli can support both immediate reflexive behaviour, such as choice and feeding, and can drive internal reinforcement in associative learning. For larval Drosophila, we here provide a first systematic behavioural analysis of these functions with respect to quinine as a study case of a s...

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Autores principales:	Amira El-Keredy, Michael Schleyer, Christian König, Aslihan Ekim, Bertram Gerber
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/23f7123899254630ae62ab3f384a747a
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spelling	oai:doaj.org-article:23f7123899254630ae62ab3f384a747a2021-11-18T07:13:00ZBehavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila.1932-620310.1371/journal.pone.0040525https://doaj.org/article/23f7123899254630ae62ab3f384a747a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22802964/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Gustatory stimuli can support both immediate reflexive behaviour, such as choice and feeding, and can drive internal reinforcement in associative learning. For larval Drosophila, we here provide a first systematic behavioural analysis of these functions with respect to quinine as a study case of a substance which humans report as "tasting bitter". We describe the dose-effect functions for these different kinds of behaviour and find that a half-maximal effect of quinine to suppress feeding needs substantially higher quinine concentrations (2.0 mM) than is the case for internal reinforcement (0.6 mM). Interestingly, in previous studies (Niewalda et al. 2008, Schipanski et al 2008) we had found the reverse for sodium chloride and fructose/sucrose, such that dose-effect functions for those tastants were shifted towards lower concentrations for feeding as compared to reinforcement, arguing that the differences in dose-effect function between these behaviours do not reflect artefacts of the types of assay used. The current results regarding quinine thus provide a starting point to investigate how the gustatory system is organized on the cellular and/or molecular level to result in different behavioural tuning curves towards a bitter tastant.Amira El-KeredyMichael SchleyerChristian KönigAslihan EkimBertram GerberPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e40525 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amira El-Keredy Michael Schleyer Christian König Aslihan Ekim Bertram Gerber Behavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila.
description	Gustatory stimuli can support both immediate reflexive behaviour, such as choice and feeding, and can drive internal reinforcement in associative learning. For larval Drosophila, we here provide a first systematic behavioural analysis of these functions with respect to quinine as a study case of a substance which humans report as "tasting bitter". We describe the dose-effect functions for these different kinds of behaviour and find that a half-maximal effect of quinine to suppress feeding needs substantially higher quinine concentrations (2.0 mM) than is the case for internal reinforcement (0.6 mM). Interestingly, in previous studies (Niewalda et al. 2008, Schipanski et al 2008) we had found the reverse for sodium chloride and fructose/sucrose, such that dose-effect functions for those tastants were shifted towards lower concentrations for feeding as compared to reinforcement, arguing that the differences in dose-effect function between these behaviours do not reflect artefacts of the types of assay used. The current results regarding quinine thus provide a starting point to investigate how the gustatory system is organized on the cellular and/or molecular level to result in different behavioural tuning curves towards a bitter tastant.
format	article
author	Amira El-Keredy Michael Schleyer Christian König Aslihan Ekim Bertram Gerber
author_facet	Amira El-Keredy Michael Schleyer Christian König Aslihan Ekim Bertram Gerber
author_sort	Amira El-Keredy
title	Behavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila.
title_short	Behavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila.
title_full	Behavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila.
title_fullStr	Behavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila.
title_full_unstemmed	Behavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila.
title_sort	behavioural analyses of quinine processing in choice, feeding and learning of larval drosophila.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/23f7123899254630ae62ab3f384a747a
work_keys_str_mv	AT amiraelkeredy behaviouralanalysesofquinineprocessinginchoicefeedingandlearningoflarvaldrosophila AT michaelschleyer behaviouralanalysesofquinineprocessinginchoicefeedingandlearningoflarvaldrosophila AT christiankonig behaviouralanalysesofquinineprocessinginchoicefeedingandlearningoflarvaldrosophila AT aslihanekim behaviouralanalysesofquinineprocessinginchoicefeedingandlearningoflarvaldrosophila AT bertramgerber behaviouralanalysesofquinineprocessinginchoicefeedingandlearningoflarvaldrosophila
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Behavioural analyses of quinine processing in choice, feeding and learning of larval Drosophila.

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