Lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus

Background. The mechanisms underlying the close relationship between diabetes mellitus (DM) and coronary artery disease (CAD) have not been fully understood. The pathophysiological processes of vascular inflammation that accelerate and enhance the development of atherosclerotic vascular lesions and...

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Autores principales:	Tatiana I. Petelina, Natalia A. Musikhina, Liudmila I. Gapom, Irina V. Емеneva, Elena A. Gorbatenko
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2017
Materias:	diabetes mellitus coronary artery disease lipid profile inflammation Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/23f9788fa2f4455d8db1fff27ab66816
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spelling	oai:doaj.org-article:23f9788fa2f4455d8db1fff27ab668162021-11-14T09:00:21ZLipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus2072-03512072-037810.14341/7959https://doaj.org/article/23f9788fa2f4455d8db1fff27ab668162017-08-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8246https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background. The mechanisms underlying the close relationship between diabetes mellitus (DM) and coronary artery disease (CAD) have not been fully understood. The pathophysiological processes of vascular inflammation that accelerate and enhance the development of atherosclerotic vascular lesions and their complications warrant further study. Aims. To compare lipid profiles and inflammatory markers in patients with CAD and stable angina in the presence and absence of type 2 DM. Materials and methods. A total of 169 patients were examined: Group 1 included 123 patients with CAD but without DM; Group 2 consisted of 46 patients with CAD and DM. The biochemical parameters were estimated before coronary angiography. Results. The lipid profile in both groups of patients revealed elevated levels of atherogenic markers (TС, LDL, VLDLP and TG). Patients in Group 2 had significantly increased levels of vascular inflammatory markers (hs-CRP, homocysteine, IL-1β), TNF-α, MMP-9 and endothelin-1 compared to those in Group 1. Conclusions. Our results indicate that the vascular inflammatory response was more pronounced in patients with CAD and DM and that they have an increased risk of developing adverse vascular complications.Tatiana I. PetelinaNatalia A. MusikhinaLiudmila I. GapomIrina V. ЕмеnevaElena A. GorbatenkoEndocrinology Research Centrearticlediabetes mellituscoronary artery diseaselipid profileinflammationNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 3, Pp 194-200 (2017)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	diabetes mellitus coronary artery disease lipid profile inflammation Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	diabetes mellitus coronary artery disease lipid profile inflammation Nutritional diseases. Deficiency diseases RC620-627 Tatiana I. Petelina Natalia A. Musikhina Liudmila I. Gapom Irina V. Емеneva Elena A. Gorbatenko Lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus
description	Background. The mechanisms underlying the close relationship between diabetes mellitus (DM) and coronary artery disease (CAD) have not been fully understood. The pathophysiological processes of vascular inflammation that accelerate and enhance the development of atherosclerotic vascular lesions and their complications warrant further study. Aims. To compare lipid profiles and inflammatory markers in patients with CAD and stable angina in the presence and absence of type 2 DM. Materials and methods. A total of 169 patients were examined: Group 1 included 123 patients with CAD but without DM; Group 2 consisted of 46 patients with CAD and DM. The biochemical parameters were estimated before coronary angiography. Results. The lipid profile in both groups of patients revealed elevated levels of atherogenic markers (TС, LDL, VLDLP and TG). Patients in Group 2 had significantly increased levels of vascular inflammatory markers (hs-CRP, homocysteine, IL-1β), TNF-α, MMP-9 and endothelin-1 compared to those in Group 1. Conclusions. Our results indicate that the vascular inflammatory response was more pronounced in patients with CAD and DM and that they have an increased risk of developing adverse vascular complications.
format	article
author	Tatiana I. Petelina Natalia A. Musikhina Liudmila I. Gapom Irina V. Емеneva Elena A. Gorbatenko
author_facet	Tatiana I. Petelina Natalia A. Musikhina Liudmila I. Gapom Irina V. Емеneva Elena A. Gorbatenko
author_sort	Tatiana I. Petelina
title	Lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus
title_short	Lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus
title_full	Lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus
title_fullStr	Lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus
title_full_unstemmed	Lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus
title_sort	lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2017
url	https://doaj.org/article/23f9788fa2f4455d8db1fff27ab66816
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Lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus

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