IDENTIFICATION MARKERS OF INFECTION DUE TO C. TRACHOMATIS AND C. PNEUMONIAE, IN PATIENTS WITH DISEASES OF THE GASTROINTESTINAL TRACT

To date, clinical data have convincingly shown that C. trachomatis and C. pneumoniae infectious can cause serious diseases with severe complications and consequences. There are assumptions that the developed chronic chlamydial infection can become an important factor in the pathogenesis of the gastr...

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Autores principales:	N. E. Bondareva, E. Yu. Morgunova, N. A. Zigangirova, Yu. G. Shapkin, Yu. V. Chalyk, R. Yu. Chalyk
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2018
Materias:	c. trachomatis c. pneumoniae chlamydial infection persistent infection gastrointestinal tract pcr Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/23ff0f26b67042918cf032caa6176405
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spelling	oai:doaj.org-article:23ff0f26b67042918cf032caa61764052021-11-22T07:09:49ZIDENTIFICATION MARKERS OF INFECTION DUE TO C. TRACHOMATIS AND C. PNEUMONIAE, IN PATIENTS WITH DISEASES OF THE GASTROINTESTINAL TRACT2220-76192313-739810.15789/2220-7619-2018-3-316-324https://doaj.org/article/23ff0f26b67042918cf032caa61764052018-11-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/781https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398To date, clinical data have convincingly shown that C. trachomatis and C. pneumoniae infectious can cause serious diseases with severe complications and consequences. There are assumptions that the developed chronic chlamydial infection can become an important factor in the pathogenesis of the gastrointestinal tract diseases, which are manifested in the so-called post-infectious period. It is commonly known that chlamydial infection has a tropism to the cylindrical epithelium, which covers the human mucous membrane of the urethra, cervix, rectum, conjunctiva of the eyes and the throat. However, the role of the causative agents of chlamydial infections, such as C. trachomatis and C. pneumoniae, in the occurrence of the gastrointestinal tract diseases has not been studied. In order to study the possible relationship between the gastrointestinal diseases and the presence of chlamydial infection markers, we have selected a group of patients with the gastrointestinal diseases and detected antibodies to C. trachomatis and C. pneumoniae and DNA of these pathogens in blood serum, liver biopsy and bile ducts. As a result, C. trachomatis DNA in blood serum was detected in 50% of cases, and in liver biopsies — in 59.3%. A new approach has been developed in the serological diagnosis of chlamydial infection caused by C. trachomatis, which allowed for revealing diagnostic antibody titers in 51.9% of cases in this group of patients, and in the comparison group — in 11.6% of cases. Among 50% of patients, in whom DNA was revealed in blood serum, it was also revealed in 64.3% of cases in biopsy samples of gastrointestinal organs. Upon detection of C. trachomatis DNA in blood serum, antibodies to the “cultural” antigen were detected in 60.1% of cases, and with the simultaneous detection of C. trachomatis DNA in blood serum and gastrointestinal organs, they were found in 72.2% of cases. Simultaneous detection of C. trachomatis, both in blood serum and in the gastrointestinal tract, may indicate the ability of C. trachomatis to spread hematogenously and infect organs away from the primary focus of infection. The obtained data absolutely require further study in light of the identification of the relationship between the detection of the pathogen and the development of the gastrointestinal pathology. But in general, the results are not yet studied evidence of the possible gastrointestinal organs infection by C. trachomatis.N. E. BondarevaE. Yu. MorgunovaN. A. ZigangirovaYu. G. ShapkinYu. V. ChalykR. Yu. ChalykSankt-Peterburg : NIIÈM imeni Pasteraarticlec. trachomatisc. pneumoniaechlamydial infectionpersistent infectiongastrointestinal tractpcrInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 8, Iss 3, Pp 316-324 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	c. trachomatis c. pneumoniae chlamydial infection persistent infection gastrointestinal tract pcr Infectious and parasitic diseases RC109-216
spellingShingle	c. trachomatis c. pneumoniae chlamydial infection persistent infection gastrointestinal tract pcr Infectious and parasitic diseases RC109-216 N. E. Bondareva E. Yu. Morgunova N. A. Zigangirova Yu. G. Shapkin Yu. V. Chalyk R. Yu. Chalyk IDENTIFICATION MARKERS OF INFECTION DUE TO C. TRACHOMATIS AND C. PNEUMONIAE, IN PATIENTS WITH DISEASES OF THE GASTROINTESTINAL TRACT
description	To date, clinical data have convincingly shown that C. trachomatis and C. pneumoniae infectious can cause serious diseases with severe complications and consequences. There are assumptions that the developed chronic chlamydial infection can become an important factor in the pathogenesis of the gastrointestinal tract diseases, which are manifested in the so-called post-infectious period. It is commonly known that chlamydial infection has a tropism to the cylindrical epithelium, which covers the human mucous membrane of the urethra, cervix, rectum, conjunctiva of the eyes and the throat. However, the role of the causative agents of chlamydial infections, such as C. trachomatis and C. pneumoniae, in the occurrence of the gastrointestinal tract diseases has not been studied. In order to study the possible relationship between the gastrointestinal diseases and the presence of chlamydial infection markers, we have selected a group of patients with the gastrointestinal diseases and detected antibodies to C. trachomatis and C. pneumoniae and DNA of these pathogens in blood serum, liver biopsy and bile ducts. As a result, C. trachomatis DNA in blood serum was detected in 50% of cases, and in liver biopsies — in 59.3%. A new approach has been developed in the serological diagnosis of chlamydial infection caused by C. trachomatis, which allowed for revealing diagnostic antibody titers in 51.9% of cases in this group of patients, and in the comparison group — in 11.6% of cases. Among 50% of patients, in whom DNA was revealed in blood serum, it was also revealed in 64.3% of cases in biopsy samples of gastrointestinal organs. Upon detection of C. trachomatis DNA in blood serum, antibodies to the “cultural” antigen were detected in 60.1% of cases, and with the simultaneous detection of C. trachomatis DNA in blood serum and gastrointestinal organs, they were found in 72.2% of cases. Simultaneous detection of C. trachomatis, both in blood serum and in the gastrointestinal tract, may indicate the ability of C. trachomatis to spread hematogenously and infect organs away from the primary focus of infection. The obtained data absolutely require further study in light of the identification of the relationship between the detection of the pathogen and the development of the gastrointestinal pathology. But in general, the results are not yet studied evidence of the possible gastrointestinal organs infection by C. trachomatis.
format	article
author	N. E. Bondareva E. Yu. Morgunova N. A. Zigangirova Yu. G. Shapkin Yu. V. Chalyk R. Yu. Chalyk
author_facet	N. E. Bondareva E. Yu. Morgunova N. A. Zigangirova Yu. G. Shapkin Yu. V. Chalyk R. Yu. Chalyk
author_sort	N. E. Bondareva
title	IDENTIFICATION MARKERS OF INFECTION DUE TO C. TRACHOMATIS AND C. PNEUMONIAE, IN PATIENTS WITH DISEASES OF THE GASTROINTESTINAL TRACT
title_short	IDENTIFICATION MARKERS OF INFECTION DUE TO C. TRACHOMATIS AND C. PNEUMONIAE, IN PATIENTS WITH DISEASES OF THE GASTROINTESTINAL TRACT
title_full	IDENTIFICATION MARKERS OF INFECTION DUE TO C. TRACHOMATIS AND C. PNEUMONIAE, IN PATIENTS WITH DISEASES OF THE GASTROINTESTINAL TRACT
title_fullStr	IDENTIFICATION MARKERS OF INFECTION DUE TO C. TRACHOMATIS AND C. PNEUMONIAE, IN PATIENTS WITH DISEASES OF THE GASTROINTESTINAL TRACT
title_full_unstemmed	IDENTIFICATION MARKERS OF INFECTION DUE TO C. TRACHOMATIS AND C. PNEUMONIAE, IN PATIENTS WITH DISEASES OF THE GASTROINTESTINAL TRACT
title_sort	identification markers of infection due to c. trachomatis and c. pneumoniae, in patients with diseases of the gastrointestinal tract
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2018
url	https://doaj.org/article/23ff0f26b67042918cf032caa6176405
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IDENTIFICATION MARKERS OF INFECTION DUE TO C. TRACHOMATIS AND C. PNEUMONIAE, IN PATIENTS WITH DISEASES OF THE GASTROINTESTINAL TRACT

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