In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori

Helicobacter pylori is a major cause of gastric diseases, but the standard therapy is limited by continuously decreased therapeutic efficacy and side effects to symbiotic bacteria. Here, the authors develop a pH-responsive graphitic nanozyme that is active under low pH gastric conditions, but inacti...

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Autores principales:	Lufeng Zhang, Liang Zhang, Hui Deng, Huan Li, Wentao Tang, Luyao Guan, Ye Qiu, Michael J. Donovan, Zhuo Chen, Weihong Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2400b84cd93248a9bd89a14c7d4381de
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spelling	oai:doaj.org-article:2400b84cd93248a9bd89a14c7d4381de2021-12-02T18:18:03ZIn vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori10.1038/s41467-021-22286-x2041-1723https://doaj.org/article/2400b84cd93248a9bd89a14c7d4381de2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22286-xhttps://doaj.org/toc/2041-1723Helicobacter pylori is a major cause of gastric diseases, but the standard therapy is limited by continuously decreased therapeutic efficacy and side effects to symbiotic bacteria. Here, the authors develop a pH-responsive graphitic nanozyme that is active under low pH gastric conditions, but inactive in intestines, for selective treatment of H. pylori infections.Lufeng ZhangLiang ZhangHui DengHuan LiWentao TangLuyao GuanYe QiuMichael J. DonovanZhuo ChenWeihong TanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lufeng Zhang Liang Zhang Hui Deng Huan Li Wentao Tang Luyao Guan Ye Qiu Michael J. Donovan Zhuo Chen Weihong Tan In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori
description	Helicobacter pylori is a major cause of gastric diseases, but the standard therapy is limited by continuously decreased therapeutic efficacy and side effects to symbiotic bacteria. Here, the authors develop a pH-responsive graphitic nanozyme that is active under low pH gastric conditions, but inactive in intestines, for selective treatment of H. pylori infections.
format	article
author	Lufeng Zhang Liang Zhang Hui Deng Huan Li Wentao Tang Luyao Guan Ye Qiu Michael J. Donovan Zhuo Chen Weihong Tan
author_facet	Lufeng Zhang Liang Zhang Hui Deng Huan Li Wentao Tang Luyao Guan Ye Qiu Michael J. Donovan Zhuo Chen Weihong Tan
author_sort	Lufeng Zhang
title	In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori
title_short	In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori
title_full	In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori
title_fullStr	In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori
title_full_unstemmed	In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori
title_sort	in vivo activation of ph-responsive oxidase-like graphitic nanozymes for selective killing of helicobacter pylori
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2400b84cd93248a9bd89a14c7d4381de
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In vivo activation of pH-responsive oxidase-like graphitic nanozymes for selective killing of Helicobacter pylori

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