Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?

<h4>Background</h4>To date, experimental and preclinical studies on neuropsychiatric conditions have almost exclusively been performed in experimentally-induced animal models and have only rarely relied upon an ethological approach where animals have been observed in more naturalistic se...

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Autores principales:	Sandrine M J Camus, Catherine Blois-Heulin, Qin Li, Martine Hausberger, Erwan Bezard
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/240425438901437cb4b6f6bd2211619d
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spelling	oai:doaj.org-article:240425438901437cb4b6f6bd2211619d2021-11-18T07:47:34ZBehavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?1932-620310.1371/journal.pone.0062141https://doaj.org/article/240425438901437cb4b6f6bd2211619d2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23658620/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>To date, experimental and preclinical studies on neuropsychiatric conditions have almost exclusively been performed in experimentally-induced animal models and have only rarely relied upon an ethological approach where animals have been observed in more naturalistic settings. The laboratory species of choice has been the rodent while the potential of more closely-related non-human primates have remained largely underexplored.<h4>Methods</h4>The present study, therefore, aimed at investigating the possible existence of spontaneous atypical/abnormal behaviours displayed by 40 cynomolgus macaques in captive conditions using an unbiased ethological scan-sampling analysis followed by multifactorial correspondence analysis and a hierarchical clustering.<h4>Results</h4>The study identified five distinct profiles (groups A to E) that significantly differed on several behaviours, body postures, body orientations, gaze directions and locations in the cage environment. We suggest that animals from the low n groups (D and E) present depressive-like and anxious-like symptoms, reminiscent of depressive and generalized anxiety disorders. Inter-individual differences were highlighted through unbiased ethological observations of spontaneous behaviours and associated parameters, although these were not associated with differences in plasma or cerebrospinal fluid levels of either stress-related hormones or monoamines, i.e. in accordance with the human situation.<h4>Conclusions</h4>No interventional behavioural testing was required to discriminate between 3 typical and 2 atypical ethologically-defined behavioural profiles, reminiscent of certain depressive-like and anxiety-like symptoms. The use of unbiased behavioural observations might, thus, allow the identification of animal models of human mental/behavioural disorders and their most appropriate control groups.Sandrine M J CamusCatherine Blois-HeulinQin LiMartine HausbergerErwan BezardPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e62141 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandrine M J Camus Catherine Blois-Heulin Qin Li Martine Hausberger Erwan Bezard Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
description	<h4>Background</h4>To date, experimental and preclinical studies on neuropsychiatric conditions have almost exclusively been performed in experimentally-induced animal models and have only rarely relied upon an ethological approach where animals have been observed in more naturalistic settings. The laboratory species of choice has been the rodent while the potential of more closely-related non-human primates have remained largely underexplored.<h4>Methods</h4>The present study, therefore, aimed at investigating the possible existence of spontaneous atypical/abnormal behaviours displayed by 40 cynomolgus macaques in captive conditions using an unbiased ethological scan-sampling analysis followed by multifactorial correspondence analysis and a hierarchical clustering.<h4>Results</h4>The study identified five distinct profiles (groups A to E) that significantly differed on several behaviours, body postures, body orientations, gaze directions and locations in the cage environment. We suggest that animals from the low n groups (D and E) present depressive-like and anxious-like symptoms, reminiscent of depressive and generalized anxiety disorders. Inter-individual differences were highlighted through unbiased ethological observations of spontaneous behaviours and associated parameters, although these were not associated with differences in plasma or cerebrospinal fluid levels of either stress-related hormones or monoamines, i.e. in accordance with the human situation.<h4>Conclusions</h4>No interventional behavioural testing was required to discriminate between 3 typical and 2 atypical ethologically-defined behavioural profiles, reminiscent of certain depressive-like and anxiety-like symptoms. The use of unbiased behavioural observations might, thus, allow the identification of animal models of human mental/behavioural disorders and their most appropriate control groups.
format	article
author	Sandrine M J Camus Catherine Blois-Heulin Qin Li Martine Hausberger Erwan Bezard
author_facet	Sandrine M J Camus Catherine Blois-Heulin Qin Li Martine Hausberger Erwan Bezard
author_sort	Sandrine M J Camus
title	Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
title_short	Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
title_full	Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
title_fullStr	Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
title_full_unstemmed	Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
title_sort	behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/240425438901437cb4b6f6bd2211619d
work_keys_str_mv	AT sandrinemjcamus behaviouralprofilesincaptivebredcynomolgusmacaquestowardsmonkeymodelsofmentaldisorders AT catherinebloisheulin behaviouralprofilesincaptivebredcynomolgusmacaquestowardsmonkeymodelsofmentaldisorders AT qinli behaviouralprofilesincaptivebredcynomolgusmacaquestowardsmonkeymodelsofmentaldisorders AT martinehausberger behaviouralprofilesincaptivebredcynomolgusmacaquestowardsmonkeymodelsofmentaldisorders AT erwanbezard behaviouralprofilesincaptivebredcynomolgusmacaquestowardsmonkeymodelsofmentaldisorders
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Behavioural profiles in captive-bred cynomolgus macaques: towards monkey models of mental disorders?

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