Large scale enzyme based xenobiotic identification for exposomics

Humans are exposed to many xenobiotic chemicals, but identification of low abundance xenobiotic exposures is limited by a lack of authentic standards for xenobiotic metabolites. Here the authors develop methods for enzymatic generation of diverse xenobiotic metabolites for use with high-resolution m...

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Autores principales:	Ken H. Liu, Choon M. Lee, Grant Singer, Preeti Bais, Francisco Castellanos, Michael H. Woodworth, Thomas R. Ziegler, Colleen S. Kraft, Gary W. Miller, Shuzhao Li, Young-Mi Go, Edward T. Morgan, Dean P. Jones
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/24042d80ee724a66ab3e8b75b1b0174e
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spelling	oai:doaj.org-article:24042d80ee724a66ab3e8b75b1b0174e2021-12-02T18:33:47ZLarge scale enzyme based xenobiotic identification for exposomics10.1038/s41467-021-25698-x2041-1723https://doaj.org/article/24042d80ee724a66ab3e8b75b1b0174e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25698-xhttps://doaj.org/toc/2041-1723Humans are exposed to many xenobiotic chemicals, but identification of low abundance xenobiotic exposures is limited by a lack of authentic standards for xenobiotic metabolites. Here the authors develop methods for enzymatic generation of diverse xenobiotic metabolites for use with high-resolution mass spectrometry for biology-based chemical identification.Ken H. LiuChoon M. LeeGrant SingerPreeti BaisFrancisco CastellanosMichael H. WoodworthThomas R. ZieglerColleen S. KraftGary W. MillerShuzhao LiYoung-Mi GoEdward T. MorganDean P. JonesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ken H. Liu Choon M. Lee Grant Singer Preeti Bais Francisco Castellanos Michael H. Woodworth Thomas R. Ziegler Colleen S. Kraft Gary W. Miller Shuzhao Li Young-Mi Go Edward T. Morgan Dean P. Jones Large scale enzyme based xenobiotic identification for exposomics
description	Humans are exposed to many xenobiotic chemicals, but identification of low abundance xenobiotic exposures is limited by a lack of authentic standards for xenobiotic metabolites. Here the authors develop methods for enzymatic generation of diverse xenobiotic metabolites for use with high-resolution mass spectrometry for biology-based chemical identification.
format	article
author	Ken H. Liu Choon M. Lee Grant Singer Preeti Bais Francisco Castellanos Michael H. Woodworth Thomas R. Ziegler Colleen S. Kraft Gary W. Miller Shuzhao Li Young-Mi Go Edward T. Morgan Dean P. Jones
author_facet	Ken H. Liu Choon M. Lee Grant Singer Preeti Bais Francisco Castellanos Michael H. Woodworth Thomas R. Ziegler Colleen S. Kraft Gary W. Miller Shuzhao Li Young-Mi Go Edward T. Morgan Dean P. Jones
author_sort	Ken H. Liu
title	Large scale enzyme based xenobiotic identification for exposomics
title_short	Large scale enzyme based xenobiotic identification for exposomics
title_full	Large scale enzyme based xenobiotic identification for exposomics
title_fullStr	Large scale enzyme based xenobiotic identification for exposomics
title_full_unstemmed	Large scale enzyme based xenobiotic identification for exposomics
title_sort	large scale enzyme based xenobiotic identification for exposomics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/24042d80ee724a66ab3e8b75b1b0174e
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Large scale enzyme based xenobiotic identification for exposomics

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