Learning mutational signatures and their multidimensional genomic properties with TensorSignatures

Currently available tools for the analysis of mutational signatures do not make use of all possible genomic properties aside from mutation patterns. Here the authors present TensorSignatures, an efficient framework that jointly infers mutational signatures and their genomic determinants.

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Detalles Bibliográficos
Autores principales: Harald Vöhringer, Arne Van Hoeck, Edwin Cuppen, Moritz Gerstung
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2405297639f64e50aa0d98e47f6b0bb5
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Sumario:Currently available tools for the analysis of mutational signatures do not make use of all possible genomic properties aside from mutation patterns. Here the authors present TensorSignatures, an efficient framework that jointly infers mutational signatures and their genomic determinants.