Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.

Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.

Chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) are characterized by the presence of the BCR-ABL oncoprotein, which leads to activation of a plethora of pro-mitogenic and pro-survival pathways, including the mTOR signaling cascade. We provide evidence that in BCR-ABL expres...

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Autores principales: Eliza Vakana, Ahmet Dirim Arslan, Amy Szilard, Jessica K Altman, Leonidas C Platanias
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/24052efa13034cfc8650dcc815e472d7
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