The role of natural antioxidants in cisplatin-induced hepatotoxicity

Cisplatin is a potent platinum-based anticancer drug approved by the Food Drug Administration (FDA) in 1978. Despite its advantages against solid tumors, cisplatin confers toxicity to various tissues that limit its clinical uses. In cisplatin-induced hepatotoxicity, few mechanisms have been identifi...

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Autores principales:	Norhashima Abd Rashid, Syarifah Aisyah Syed Abd Halim, Seong Lin Teoh, Siti Balkis Budin, Farida Hussan, Nurul Raudzah Adib Ridzuan, Nahdia Afiifah Abdul Jalil
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Cisplatin Liver damage Natural products Herbs Complementary medicine Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/240936f4441d465ba08c096821cb8169
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spelling	oai:doaj.org-article:240936f4441d465ba08c096821cb81692021-11-14T04:29:45ZThe role of natural antioxidants in cisplatin-induced hepatotoxicity0753-332210.1016/j.biopha.2021.112328https://doaj.org/article/240936f4441d465ba08c096821cb81692021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011124https://doaj.org/toc/0753-3322Cisplatin is a potent platinum-based anticancer drug approved by the Food Drug Administration (FDA) in 1978. Despite its advantages against solid tumors, cisplatin confers toxicity to various tissues that limit its clinical uses. In cisplatin-induced hepatotoxicity, few mechanisms have been identified, which started as excess generation of reactive oxygen species that leads to oxidative stress, inflammation, DNA damage and apoptosis in the liver. Various natural products, plant extracts and oil rich in flavonoids, terpenoids, polyphenols, and phenolic acids were able to minimize oxidative stress by restoring the level of antioxidant enzymes and acting as an anti-inflammatory agent. Likewise, treatment with honey and royal jelly was demonstrated to decrease serum transaminases and scavenge free radicals in the liver after cisplatin administration. Medicinal properties of these natural products have a promising potential as a complementary therapy to counteract cisplatin-induced hepatotoxicity. This review concentrated on the protective role of several natural products, which has been proven in the laboratory findings to combat cisplatin-induced hepatotoxicity.Norhashima Abd RashidSyarifah Aisyah Syed Abd HalimSeong Lin TeohSiti Balkis BudinFarida HussanNurul Raudzah Adib RidzuanNahdia Afiifah Abdul JalilElsevierarticleCisplatinLiver damageNatural productsHerbsComplementary medicineTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112328- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cisplatin Liver damage Natural products Herbs Complementary medicine Therapeutics. Pharmacology RM1-950
spellingShingle	Cisplatin Liver damage Natural products Herbs Complementary medicine Therapeutics. Pharmacology RM1-950 Norhashima Abd Rashid Syarifah Aisyah Syed Abd Halim Seong Lin Teoh Siti Balkis Budin Farida Hussan Nurul Raudzah Adib Ridzuan Nahdia Afiifah Abdul Jalil The role of natural antioxidants in cisplatin-induced hepatotoxicity
description	Cisplatin is a potent platinum-based anticancer drug approved by the Food Drug Administration (FDA) in 1978. Despite its advantages against solid tumors, cisplatin confers toxicity to various tissues that limit its clinical uses. In cisplatin-induced hepatotoxicity, few mechanisms have been identified, which started as excess generation of reactive oxygen species that leads to oxidative stress, inflammation, DNA damage and apoptosis in the liver. Various natural products, plant extracts and oil rich in flavonoids, terpenoids, polyphenols, and phenolic acids were able to minimize oxidative stress by restoring the level of antioxidant enzymes and acting as an anti-inflammatory agent. Likewise, treatment with honey and royal jelly was demonstrated to decrease serum transaminases and scavenge free radicals in the liver after cisplatin administration. Medicinal properties of these natural products have a promising potential as a complementary therapy to counteract cisplatin-induced hepatotoxicity. This review concentrated on the protective role of several natural products, which has been proven in the laboratory findings to combat cisplatin-induced hepatotoxicity.
format	article
author	Norhashima Abd Rashid Syarifah Aisyah Syed Abd Halim Seong Lin Teoh Siti Balkis Budin Farida Hussan Nurul Raudzah Adib Ridzuan Nahdia Afiifah Abdul Jalil
author_facet	Norhashima Abd Rashid Syarifah Aisyah Syed Abd Halim Seong Lin Teoh Siti Balkis Budin Farida Hussan Nurul Raudzah Adib Ridzuan Nahdia Afiifah Abdul Jalil
author_sort	Norhashima Abd Rashid
title	The role of natural antioxidants in cisplatin-induced hepatotoxicity
title_short	The role of natural antioxidants in cisplatin-induced hepatotoxicity
title_full	The role of natural antioxidants in cisplatin-induced hepatotoxicity
title_fullStr	The role of natural antioxidants in cisplatin-induced hepatotoxicity
title_full_unstemmed	The role of natural antioxidants in cisplatin-induced hepatotoxicity
title_sort	role of natural antioxidants in cisplatin-induced hepatotoxicity
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/240936f4441d465ba08c096821cb8169
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The role of natural antioxidants in cisplatin-induced hepatotoxicity

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