Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT
Allogeneic hematopoietic cell transplantation is the standard treatment of acute myeloid leukemia, but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen specificity within bone marrow-residing memory T cells precede and potentially predict the relapse.
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Nature Portfolio
2019
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oai:doaj.org-article:2409f0f6f05e4b0d801cc717464939962021-12-02T16:58:06ZBone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT10.1038/s41467-019-08871-12041-1723https://doaj.org/article/2409f0f6f05e4b0d801cc717464939962019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08871-1https://doaj.org/toc/2041-1723Allogeneic hematopoietic cell transplantation is the standard treatment of acute myeloid leukemia, but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen specificity within bone marrow-residing memory T cells precede and potentially predict the relapse.Maddalena NovielloFrancesco ManfrediEliana RuggieroTommaso PeriniGiacomo OliveiraFilippo CortesiPantaleo De SimoneCristina ToffaloriValentina GambacortaRaffaella GrecoJacopo PeccatoriMonica CasucciGiulia CasoratiPaolo DellabonaMasahiro OnozawaTakanori TeshimaMarieke GriffioenConstantijn J. M. HalkesJ. H. F. FalkenburgFriedrich StölzelHeidi AltmannMartin BornhäuserMiguel WaterhouseRobert ZeiserJürgen FinkeNicoletta CieriAttilio BondanzaLuca VagoFabio CiceriChiara BoniniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Maddalena Noviello Francesco Manfredi Eliana Ruggiero Tommaso Perini Giacomo Oliveira Filippo Cortesi Pantaleo De Simone Cristina Toffalori Valentina Gambacorta Raffaella Greco Jacopo Peccatori Monica Casucci Giulia Casorati Paolo Dellabona Masahiro Onozawa Takanori Teshima Marieke Griffioen Constantijn J. M. Halkes J. H. F. Falkenburg Friedrich Stölzel Heidi Altmann Martin Bornhäuser Miguel Waterhouse Robert Zeiser Jürgen Finke Nicoletta Cieri Attilio Bondanza Luca Vago Fabio Ciceri Chiara Bonini Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT |
| description |
Allogeneic hematopoietic cell transplantation is the standard treatment of acute myeloid leukemia, but many patients relapse. Here the authors show increased markers of exhaustion and cancer antigen specificity within bone marrow-residing memory T cells precede and potentially predict the relapse. |
| format |
article |
| author |
Maddalena Noviello Francesco Manfredi Eliana Ruggiero Tommaso Perini Giacomo Oliveira Filippo Cortesi Pantaleo De Simone Cristina Toffalori Valentina Gambacorta Raffaella Greco Jacopo Peccatori Monica Casucci Giulia Casorati Paolo Dellabona Masahiro Onozawa Takanori Teshima Marieke Griffioen Constantijn J. M. Halkes J. H. F. Falkenburg Friedrich Stölzel Heidi Altmann Martin Bornhäuser Miguel Waterhouse Robert Zeiser Jürgen Finke Nicoletta Cieri Attilio Bondanza Luca Vago Fabio Ciceri Chiara Bonini |
| author_facet |
Maddalena Noviello Francesco Manfredi Eliana Ruggiero Tommaso Perini Giacomo Oliveira Filippo Cortesi Pantaleo De Simone Cristina Toffalori Valentina Gambacorta Raffaella Greco Jacopo Peccatori Monica Casucci Giulia Casorati Paolo Dellabona Masahiro Onozawa Takanori Teshima Marieke Griffioen Constantijn J. M. Halkes J. H. F. Falkenburg Friedrich Stölzel Heidi Altmann Martin Bornhäuser Miguel Waterhouse Robert Zeiser Jürgen Finke Nicoletta Cieri Attilio Bondanza Luca Vago Fabio Ciceri Chiara Bonini |
| author_sort |
Maddalena Noviello |
| title |
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT |
| title_short |
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT |
| title_full |
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT |
| title_fullStr |
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT |
| title_full_unstemmed |
Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT |
| title_sort |
bone marrow central memory and memory stem t-cell exhaustion in aml patients relapsing after hsct |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/2409f0f6f05e4b0d801cc71746493996 |
| work_keys_str_mv |
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