Role of Specialized Pro-Resolving Mediators in Modifying Host Defense and Decreasing Bacterial Virulence

Bacterial infection activates the innate immune system as part of the host’s defense against invading pathogens. Host response to bacterial pathogens includes leukocyte activation, inflammatory mediator release, phagocytosis, and killing of bacteria. An appropriate host response requires resolution....

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Autores principales:	Julianne M. Thornton, Kingsley Yin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	resolvins lipoxin quorum sensing innate immunity neutrophils macrophages Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/241061a65e7a48fbb393f9fe36bc6765
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spelling	oai:doaj.org-article:241061a65e7a48fbb393f9fe36bc67652021-11-25T18:28:49ZRole of Specialized Pro-Resolving Mediators in Modifying Host Defense and Decreasing Bacterial Virulence10.3390/molecules262269701420-3049https://doaj.org/article/241061a65e7a48fbb393f9fe36bc67652021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6970https://doaj.org/toc/1420-3049Bacterial infection activates the innate immune system as part of the host’s defense against invading pathogens. Host response to bacterial pathogens includes leukocyte activation, inflammatory mediator release, phagocytosis, and killing of bacteria. An appropriate host response requires resolution. The resolution phase involves attenuation of neutrophil migration, neutrophil apoptosis, macrophage recruitment, increased phagocytosis, efferocytosis of apoptotic neutrophils, and tissue repair. Specialized Pro-resolving Mediators (SPMs) are bioactive fatty acids that were shown to be highly effective in promoting resolution of infectious inflammation and survival in several models of infection. In this review, we provide insight into the role of SPMs in active host defense mechanisms for bacterial clearance including a new mechanism of action in which an SPM acts directly to reduce bacterial virulence.Julianne M. ThorntonKingsley YinMDPI AGarticleresolvinslipoxinquorum sensinginnate immunityneutrophilsmacrophagesOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6970, p 6970 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	resolvins lipoxin quorum sensing innate immunity neutrophils macrophages Organic chemistry QD241-441
spellingShingle	resolvins lipoxin quorum sensing innate immunity neutrophils macrophages Organic chemistry QD241-441 Julianne M. Thornton Kingsley Yin Role of Specialized Pro-Resolving Mediators in Modifying Host Defense and Decreasing Bacterial Virulence
description	Bacterial infection activates the innate immune system as part of the host’s defense against invading pathogens. Host response to bacterial pathogens includes leukocyte activation, inflammatory mediator release, phagocytosis, and killing of bacteria. An appropriate host response requires resolution. The resolution phase involves attenuation of neutrophil migration, neutrophil apoptosis, macrophage recruitment, increased phagocytosis, efferocytosis of apoptotic neutrophils, and tissue repair. Specialized Pro-resolving Mediators (SPMs) are bioactive fatty acids that were shown to be highly effective in promoting resolution of infectious inflammation and survival in several models of infection. In this review, we provide insight into the role of SPMs in active host defense mechanisms for bacterial clearance including a new mechanism of action in which an SPM acts directly to reduce bacterial virulence.
format	article
author	Julianne M. Thornton Kingsley Yin
author_facet	Julianne M. Thornton Kingsley Yin
author_sort	Julianne M. Thornton
title	Role of Specialized Pro-Resolving Mediators in Modifying Host Defense and Decreasing Bacterial Virulence
title_short	Role of Specialized Pro-Resolving Mediators in Modifying Host Defense and Decreasing Bacterial Virulence
title_full	Role of Specialized Pro-Resolving Mediators in Modifying Host Defense and Decreasing Bacterial Virulence
title_fullStr	Role of Specialized Pro-Resolving Mediators in Modifying Host Defense and Decreasing Bacterial Virulence
title_full_unstemmed	Role of Specialized Pro-Resolving Mediators in Modifying Host Defense and Decreasing Bacterial Virulence
title_sort	role of specialized pro-resolving mediators in modifying host defense and decreasing bacterial virulence
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/241061a65e7a48fbb393f9fe36bc6765
work_keys_str_mv	AT juliannemthornton roleofspecializedproresolvingmediatorsinmodifyinghostdefenseanddecreasingbacterialvirulence AT kingsleyyin roleofspecializedproresolvingmediatorsinmodifyinghostdefenseanddecreasingbacterialvirulence
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Role of Specialized Pro-Resolving Mediators in Modifying Host Defense and Decreasing Bacterial Virulence

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