A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer
Alcohol and smoking are both associated with oral/oropharyngeal cancer risk, but independent effects are unclear given their relatedness. Here, the authors use multivariable Mendelian randomization to show that both alcohol and smoking are independently causal for oral/oropharyngeal cancer.
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Nature Portfolio
2020
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| Acceso en línea: | https://doaj.org/article/24133f68982d42489b8be201ba8c4035 |
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oai:doaj.org-article:24133f68982d42489b8be201ba8c40352021-12-02T14:41:15ZA multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer10.1038/s41467-020-19822-62041-1723https://doaj.org/article/24133f68982d42489b8be201ba8c40352020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19822-6https://doaj.org/toc/2041-1723Alcohol and smoking are both associated with oral/oropharyngeal cancer risk, but independent effects are unclear given their relatedness. Here, the authors use multivariable Mendelian randomization to show that both alcohol and smoking are independently causal for oral/oropharyngeal cancer.Mark GormleyTom DuddingEleanor SandersonRichard M. MartinSteven ThomasJessica TyrrellAndrew R. NessPaul BrennanMarcus MunafòMiranda PringStefania BocciaAndrew F. OlshanBrenda DiergaardeRayjean J. HungGeoffrey LiuGeorge Davey SmithRebecca C. RichmondNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Mark Gormley Tom Dudding Eleanor Sanderson Richard M. Martin Steven Thomas Jessica Tyrrell Andrew R. Ness Paul Brennan Marcus Munafò Miranda Pring Stefania Boccia Andrew F. Olshan Brenda Diergaarde Rayjean J. Hung Geoffrey Liu George Davey Smith Rebecca C. Richmond A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer |
| description |
Alcohol and smoking are both associated with oral/oropharyngeal cancer risk, but independent effects are unclear given their relatedness. Here, the authors use multivariable Mendelian randomization to show that both alcohol and smoking are independently causal for oral/oropharyngeal cancer. |
| format |
article |
| author |
Mark Gormley Tom Dudding Eleanor Sanderson Richard M. Martin Steven Thomas Jessica Tyrrell Andrew R. Ness Paul Brennan Marcus Munafò Miranda Pring Stefania Boccia Andrew F. Olshan Brenda Diergaarde Rayjean J. Hung Geoffrey Liu George Davey Smith Rebecca C. Richmond |
| author_facet |
Mark Gormley Tom Dudding Eleanor Sanderson Richard M. Martin Steven Thomas Jessica Tyrrell Andrew R. Ness Paul Brennan Marcus Munafò Miranda Pring Stefania Boccia Andrew F. Olshan Brenda Diergaarde Rayjean J. Hung Geoffrey Liu George Davey Smith Rebecca C. Richmond |
| author_sort |
Mark Gormley |
| title |
A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer |
| title_short |
A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer |
| title_full |
A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer |
| title_fullStr |
A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer |
| title_full_unstemmed |
A multivariable Mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer |
| title_sort |
multivariable mendelian randomization analysis investigating smoking and alcohol consumption in oral and oropharyngeal cancer |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/24133f68982d42489b8be201ba8c4035 |
| work_keys_str_mv |
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