Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28

T help 17 (Th17) cells are important mediators for both protective and pathogenic immune reactions, but how their functions are regulated at the epigenetic level is not understood. Here the authors show that TRIM28, a cofactor for transcriptional regulation, is important for epigenetic activation of...

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Autores principales:	Yu Jiang, Ying Liu, Huiping Lu, Shao-Cong Sun, Wei Jin, Xiaohu Wang, Chen Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2413a43527724d8b99121a569ff9a4f6
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id	oai:doaj.org-article:2413a43527724d8b99121a569ff9a4f6
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spelling	oai:doaj.org-article:2413a43527724d8b99121a569ff9a4f62021-12-02T15:34:44ZEpigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 2810.1038/s41467-018-03852-22041-1723https://doaj.org/article/2413a43527724d8b99121a569ff9a4f62018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03852-2https://doaj.org/toc/2041-1723T help 17 (Th17) cells are important mediators for both protective and pathogenic immune reactions, but how their functions are regulated at the epigenetic level is not understood. Here the authors show that TRIM28, a cofactor for transcriptional regulation, is important for epigenetic activation of Th17-related gene loci during Th17 response.Yu JiangYing LiuHuiping LuShao-Cong SunWei JinXiaohu WangChen DongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Jiang Ying Liu Huiping Lu Shao-Cong Sun Wei Jin Xiaohu Wang Chen Dong Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28
description	T help 17 (Th17) cells are important mediators for both protective and pathogenic immune reactions, but how their functions are regulated at the epigenetic level is not understood. Here the authors show that TRIM28, a cofactor for transcriptional regulation, is important for epigenetic activation of Th17-related gene loci during Th17 response.
format	article
author	Yu Jiang Ying Liu Huiping Lu Shao-Cong Sun Wei Jin Xiaohu Wang Chen Dong
author_facet	Yu Jiang Ying Liu Huiping Lu Shao-Cong Sun Wei Jin Xiaohu Wang Chen Dong
author_sort	Yu Jiang
title	Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28
title_short	Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28
title_full	Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28
title_fullStr	Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28
title_full_unstemmed	Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28
title_sort	epigenetic activation during t helper 17 cell differentiation is mediated by tripartite motif containing 28
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2413a43527724d8b99121a569ff9a4f6
work_keys_str_mv	AT yujiang epigeneticactivationduringthelper17celldifferentiationismediatedbytripartitemotifcontaining28 AT yingliu epigeneticactivationduringthelper17celldifferentiationismediatedbytripartitemotifcontaining28 AT huipinglu epigeneticactivationduringthelper17celldifferentiationismediatedbytripartitemotifcontaining28 AT shaocongsun epigeneticactivationduringthelper17celldifferentiationismediatedbytripartitemotifcontaining28 AT weijin epigeneticactivationduringthelper17celldifferentiationismediatedbytripartitemotifcontaining28 AT xiaohuwang epigeneticactivationduringthelper17celldifferentiationismediatedbytripartitemotifcontaining28 AT chendong epigeneticactivationduringthelper17celldifferentiationismediatedbytripartitemotifcontaining28
_version_	1718386769152442368

Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28

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