Immunoregulation and antidepressant effect of ketamine

Major depressive disorder (MDD) is a common mental health disorder that brings severe disease burden worldwide. Traditional antidepressants are mainly targeted at monoamine neurotransmitters, with low remission rates and high recurrence rates. Ketamine is a noncompetitive glutamate N-methyl-d-aspart...

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Autores principales:	Zhang Nan, Yao Lihua, Wang Peilin, Liu Zhongchun
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	ketamine depression antidepressant therapy cytokine neuroimmunity nmdar Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/24189d1466ac471dbf4a27d7aeea6650
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spelling	oai:doaj.org-article:24189d1466ac471dbf4a27d7aeea66502021-12-05T14:11:05ZImmunoregulation and antidepressant effect of ketamine2081-693610.1515/tnsci-2020-0167https://doaj.org/article/24189d1466ac471dbf4a27d7aeea66502021-05-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2020-0167https://doaj.org/toc/2081-6936Major depressive disorder (MDD) is a common mental health disorder that brings severe disease burden worldwide. Traditional antidepressants are mainly targeted at monoamine neurotransmitters, with low remission rates and high recurrence rates. Ketamine is a noncompetitive glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist, and its rapid and powerful antidepressant effects have come to light. Its antidepressant mechanism is still unclarified. Research found that ketamine had not only antagonistic effect on NMDAR but also strong immunomodulatory effect, both of which were closely related to the pathophysiology of MDD. Although there are many related studies, they are relatively heterogeneous. Therefore, this review mainly describes the immune mechanisms involved in MDD and how ketamine plays an antidepressant role by regulating peripheral and central immune system, including peripheral inflammatory cytokines, central microglia, and astrocytes. This review summarizes the related research, finds out the deficiencies of current research, and provides ideas for future research and the development of novel antidepressants.Zhang NanYao LihuaWang PeilinLiu ZhongchunDe Gruyterarticleketaminedepressionantidepressant therapycytokineneuroimmunitynmdarNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 12, Iss 1, Pp 218-236 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ketamine depression antidepressant therapy cytokine neuroimmunity nmdar Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	ketamine depression antidepressant therapy cytokine neuroimmunity nmdar Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Zhang Nan Yao Lihua Wang Peilin Liu Zhongchun Immunoregulation and antidepressant effect of ketamine
description	Major depressive disorder (MDD) is a common mental health disorder that brings severe disease burden worldwide. Traditional antidepressants are mainly targeted at monoamine neurotransmitters, with low remission rates and high recurrence rates. Ketamine is a noncompetitive glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist, and its rapid and powerful antidepressant effects have come to light. Its antidepressant mechanism is still unclarified. Research found that ketamine had not only antagonistic effect on NMDAR but also strong immunomodulatory effect, both of which were closely related to the pathophysiology of MDD. Although there are many related studies, they are relatively heterogeneous. Therefore, this review mainly describes the immune mechanisms involved in MDD and how ketamine plays an antidepressant role by regulating peripheral and central immune system, including peripheral inflammatory cytokines, central microglia, and astrocytes. This review summarizes the related research, finds out the deficiencies of current research, and provides ideas for future research and the development of novel antidepressants.
format	article
author	Zhang Nan Yao Lihua Wang Peilin Liu Zhongchun
author_facet	Zhang Nan Yao Lihua Wang Peilin Liu Zhongchun
author_sort	Zhang Nan
title	Immunoregulation and antidepressant effect of ketamine
title_short	Immunoregulation and antidepressant effect of ketamine
title_full	Immunoregulation and antidepressant effect of ketamine
title_fullStr	Immunoregulation and antidepressant effect of ketamine
title_full_unstemmed	Immunoregulation and antidepressant effect of ketamine
title_sort	immunoregulation and antidepressant effect of ketamine
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/24189d1466ac471dbf4a27d7aeea6650
work_keys_str_mv	AT zhangnan immunoregulationandantidepressanteffectofketamine AT yaolihua immunoregulationandantidepressanteffectofketamine AT wangpeilin immunoregulationandantidepressanteffectofketamine AT liuzhongchun immunoregulationandantidepressanteffectofketamine
_version_	1718371408414769152

Immunoregulation and antidepressant effect of ketamine

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