Monoterpene Indole Alkaloids with Ca<sub>v</sub>3.1 T-Type Calcium Channel Inhibitory Activity from <i>Catharanthus roseus</i>
<i>Catharanthus roseus</i> is a well-known traditional herbal medicine for the treatment of cancer, hypertension, scald, and sore in China. Phytochemical investigation on the twigs and leaves of this species led to the isolation of two new monoterpene indole alkaloids, catharanosines A (...
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2021
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oai:doaj.org-article:241be73c214a4476b95449eb51a3d2c72021-11-11T18:31:04ZMonoterpene Indole Alkaloids with Ca<sub>v</sub>3.1 T-Type Calcium Channel Inhibitory Activity from <i>Catharanthus roseus</i>10.3390/molecules262165161420-3049https://doaj.org/article/241be73c214a4476b95449eb51a3d2c72021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6516https://doaj.org/toc/1420-3049<i>Catharanthus roseus</i> is a well-known traditional herbal medicine for the treatment of cancer, hypertension, scald, and sore in China. Phytochemical investigation on the twigs and leaves of this species led to the isolation of two new monoterpene indole alkaloids, catharanosines A (<b>1</b>) and B (<b>2</b>), and six known analogues (<b>3</b>–<b>8</b>). Structures of <b>1</b> and <b>2</b> were established by <sup>1</sup>H-, <sup>13</sup>C- and 2D-NMR, and HREIMS data. The absolute configuration of <b>1</b> was confirmed by single-crystal X-ray diffraction analysis. Compound <b>2</b> represented an unprecedented aspidosperma-type alkaloid with a 2-piperidinyl moiety at C-10. Compounds <b>6</b>–<b>8</b> exhibited remarkable Ca<sub>v</sub>3.1 low voltage-gated calcium channel (LVGCC) inhibitory activity with IC<sub>50</sub> values of 11.83 ± 1.02, 14.3 ± 1.20, and 14.54 ± 0.99 μM, respectively.Zhen-Tao DengWen-Yan LiLei WangZhi-Ping ZhouXing-De WuZhong-Tao DingQin-Shi ZhaoMDPI AGarticle<i>Catharanthus roseus</i>monoterpene indole alkaloidcatharanosine ACa<sub>v</sub>3.1 low voltage-gated calcium channel (LVGCC)Organic chemistryQD241-441ENMolecules, Vol 26, Iss 6516, p 6516 (2021) |
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<i>Catharanthus roseus</i> monoterpene indole alkaloid catharanosine A Ca<sub>v</sub>3.1 low voltage-gated calcium channel (LVGCC) Organic chemistry QD241-441 |
| spellingShingle |
<i>Catharanthus roseus</i> monoterpene indole alkaloid catharanosine A Ca<sub>v</sub>3.1 low voltage-gated calcium channel (LVGCC) Organic chemistry QD241-441 Zhen-Tao Deng Wen-Yan Li Lei Wang Zhi-Ping Zhou Xing-De Wu Zhong-Tao Ding Qin-Shi Zhao Monoterpene Indole Alkaloids with Ca<sub>v</sub>3.1 T-Type Calcium Channel Inhibitory Activity from <i>Catharanthus roseus</i> |
| description |
<i>Catharanthus roseus</i> is a well-known traditional herbal medicine for the treatment of cancer, hypertension, scald, and sore in China. Phytochemical investigation on the twigs and leaves of this species led to the isolation of two new monoterpene indole alkaloids, catharanosines A (<b>1</b>) and B (<b>2</b>), and six known analogues (<b>3</b>–<b>8</b>). Structures of <b>1</b> and <b>2</b> were established by <sup>1</sup>H-, <sup>13</sup>C- and 2D-NMR, and HREIMS data. The absolute configuration of <b>1</b> was confirmed by single-crystal X-ray diffraction analysis. Compound <b>2</b> represented an unprecedented aspidosperma-type alkaloid with a 2-piperidinyl moiety at C-10. Compounds <b>6</b>–<b>8</b> exhibited remarkable Ca<sub>v</sub>3.1 low voltage-gated calcium channel (LVGCC) inhibitory activity with IC<sub>50</sub> values of 11.83 ± 1.02, 14.3 ± 1.20, and 14.54 ± 0.99 μM, respectively. |
| format |
article |
| author |
Zhen-Tao Deng Wen-Yan Li Lei Wang Zhi-Ping Zhou Xing-De Wu Zhong-Tao Ding Qin-Shi Zhao |
| author_facet |
Zhen-Tao Deng Wen-Yan Li Lei Wang Zhi-Ping Zhou Xing-De Wu Zhong-Tao Ding Qin-Shi Zhao |
| author_sort |
Zhen-Tao Deng |
| title |
Monoterpene Indole Alkaloids with Ca<sub>v</sub>3.1 T-Type Calcium Channel Inhibitory Activity from <i>Catharanthus roseus</i> |
| title_short |
Monoterpene Indole Alkaloids with Ca<sub>v</sub>3.1 T-Type Calcium Channel Inhibitory Activity from <i>Catharanthus roseus</i> |
| title_full |
Monoterpene Indole Alkaloids with Ca<sub>v</sub>3.1 T-Type Calcium Channel Inhibitory Activity from <i>Catharanthus roseus</i> |
| title_fullStr |
Monoterpene Indole Alkaloids with Ca<sub>v</sub>3.1 T-Type Calcium Channel Inhibitory Activity from <i>Catharanthus roseus</i> |
| title_full_unstemmed |
Monoterpene Indole Alkaloids with Ca<sub>v</sub>3.1 T-Type Calcium Channel Inhibitory Activity from <i>Catharanthus roseus</i> |
| title_sort |
monoterpene indole alkaloids with ca<sub>v</sub>3.1 t-type calcium channel inhibitory activity from <i>catharanthus roseus</i> |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/241be73c214a4476b95449eb51a3d2c7 |
| work_keys_str_mv |
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1718431811576528896 |