Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure

Gene-set analysis (GSA) is widely used to infer functional and biological properties of a gene set. Here, the authors develop a conditional and interaction gene-set analysis approach that can considerably refine results from traditional GSA.

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Autores principales:	Christiaan A. de Leeuw, Sven Stringer, Ilona A. Dekkers, Tom Heskes, Danielle Posthuma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/241c1127ce014dceaa058d324b4c6adf
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spelling	oai:doaj.org-article:241c1127ce014dceaa058d324b4c6adf2021-12-02T15:34:38ZConditional and interaction gene-set analysis reveals novel functional pathways for blood pressure10.1038/s41467-018-06022-62041-1723https://doaj.org/article/241c1127ce014dceaa058d324b4c6adf2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06022-6https://doaj.org/toc/2041-1723Gene-set analysis (GSA) is widely used to infer functional and biological properties of a gene set. Here, the authors develop a conditional and interaction gene-set analysis approach that can considerably refine results from traditional GSA.Christiaan A. de LeeuwSven StringerIlona A. DekkersTom HeskesDanielle PosthumaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christiaan A. de Leeuw Sven Stringer Ilona A. Dekkers Tom Heskes Danielle Posthuma Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure
description	Gene-set analysis (GSA) is widely used to infer functional and biological properties of a gene set. Here, the authors develop a conditional and interaction gene-set analysis approach that can considerably refine results from traditional GSA.
format	article
author	Christiaan A. de Leeuw Sven Stringer Ilona A. Dekkers Tom Heskes Danielle Posthuma
author_facet	Christiaan A. de Leeuw Sven Stringer Ilona A. Dekkers Tom Heskes Danielle Posthuma
author_sort	Christiaan A. de Leeuw
title	Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure
title_short	Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure
title_full	Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure
title_fullStr	Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure
title_full_unstemmed	Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure
title_sort	conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/241c1127ce014dceaa058d324b4c6adf
work_keys_str_mv	AT christiaanadeleeuw conditionalandinteractiongenesetanalysisrevealsnovelfunctionalpathwaysforbloodpressure AT svenstringer conditionalandinteractiongenesetanalysisrevealsnovelfunctionalpathwaysforbloodpressure AT ilonaadekkers conditionalandinteractiongenesetanalysisrevealsnovelfunctionalpathwaysforbloodpressure AT tomheskes conditionalandinteractiongenesetanalysisrevealsnovelfunctionalpathwaysforbloodpressure AT danielleposthuma conditionalandinteractiongenesetanalysisrevealsnovelfunctionalpathwaysforbloodpressure
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Conditional and interaction gene-set analysis reveals novel functional pathways for blood pressure

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