Extranodal natural killer/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series

Abstract Background Extranodal NK/T-cell lymphoma of the breast (ENKTL-Breast) is rarely detected in clinical practice, and its clinicopathological features remain unclear. Results A consecutive 11-year (2010–2020) ENKTL-Breast case series was retrospectively analyzed. Eight cases of ENKTL-Breast we...

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Autores principales:	Wei Liu, Zihang Chen, Fanglan Li, Wenyan Zhang, Weiping Liu, Sha Zhao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Extranodal natural killer/T-cell lymphoma Breast lymphoma T-cell lymphoma Epstein–Barr virus Medicine R
Acceso en línea:	https://doaj.org/article/241c8e423a8e48e89686a128b0103b38
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spelling	oai:doaj.org-article:241c8e423a8e48e89686a128b0103b382021-11-21T12:26:01ZExtranodal natural killer/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series10.1186/s13023-021-02110-x1750-1172https://doaj.org/article/241c8e423a8e48e89686a128b0103b382021-11-01T00:00:00Zhttps://doi.org/10.1186/s13023-021-02110-xhttps://doaj.org/toc/1750-1172Abstract Background Extranodal NK/T-cell lymphoma of the breast (ENKTL-Breast) is rarely detected in clinical practice, and its clinicopathological features remain unclear. Results A consecutive 11-year (2010–2020) ENKTL-Breast case series was retrospectively analyzed. Eight cases of ENKTL-Breast were selected, with three primary and five secondary lesions, accounting for 3.5% (8/228) of all breast lymphomas. All patients were female with a median age of 46 years. Lesions presented as solid breast masses (8/8, 100%) and were usually located in the upper outer quadrant of the breast (7/8, 87.5%). B-symptoms were observed in seven (7/8, 87.5%) cases. Two primary ENKTL-Breast cases showed concomitant diseases (IgA nephropathy and chronic active hepatitis B). Histological and immunohistochemical features of ENKTL-Breast were similar to those of ENKTL at other sites. T-cell receptor rearrangement revealed clonality in all examined primary cases (2/2, 100%), but only in one secondary case (1/5, 20%). The disease progressed rapidly in two primary cases and both patients died within 3 and 9 months. For secondary cases, the disease manifested as a disseminated disease, with a median survival time of 6 months. Conclusions Our data suggested that ENKTL-Breast clinically mimics breast cancer to some extent, though B-symptoms might serve as a distinguishing factor. ENKTL-Breast is highly aggressive and patients with this disease exhibit a short survival time. Primary ENKTL-Breast tends to originate from activated cytotoxic T-cells, and immune-related diseases may be involved in its pathogenesis and development.Wei LiuZihang ChenFanglan LiWenyan ZhangWeiping LiuSha ZhaoBMCarticleExtranodal natural killer/T-cell lymphomaBreast lymphomaT-cell lymphomaEpstein–Barr virusMedicineRENOrphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Extranodal natural killer/T-cell lymphoma Breast lymphoma T-cell lymphoma Epstein–Barr virus Medicine R
spellingShingle	Extranodal natural killer/T-cell lymphoma Breast lymphoma T-cell lymphoma Epstein–Barr virus Medicine R Wei Liu Zihang Chen Fanglan Li Wenyan Zhang Weiping Liu Sha Zhao Extranodal natural killer/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series
description	Abstract Background Extranodal NK/T-cell lymphoma of the breast (ENKTL-Breast) is rarely detected in clinical practice, and its clinicopathological features remain unclear. Results A consecutive 11-year (2010–2020) ENKTL-Breast case series was retrospectively analyzed. Eight cases of ENKTL-Breast were selected, with three primary and five secondary lesions, accounting for 3.5% (8/228) of all breast lymphomas. All patients were female with a median age of 46 years. Lesions presented as solid breast masses (8/8, 100%) and were usually located in the upper outer quadrant of the breast (7/8, 87.5%). B-symptoms were observed in seven (7/8, 87.5%) cases. Two primary ENKTL-Breast cases showed concomitant diseases (IgA nephropathy and chronic active hepatitis B). Histological and immunohistochemical features of ENKTL-Breast were similar to those of ENKTL at other sites. T-cell receptor rearrangement revealed clonality in all examined primary cases (2/2, 100%), but only in one secondary case (1/5, 20%). The disease progressed rapidly in two primary cases and both patients died within 3 and 9 months. For secondary cases, the disease manifested as a disseminated disease, with a median survival time of 6 months. Conclusions Our data suggested that ENKTL-Breast clinically mimics breast cancer to some extent, though B-symptoms might serve as a distinguishing factor. ENKTL-Breast is highly aggressive and patients with this disease exhibit a short survival time. Primary ENKTL-Breast tends to originate from activated cytotoxic T-cells, and immune-related diseases may be involved in its pathogenesis and development.
format	article
author	Wei Liu Zihang Chen Fanglan Li Wenyan Zhang Weiping Liu Sha Zhao
author_facet	Wei Liu Zihang Chen Fanglan Li Wenyan Zhang Weiping Liu Sha Zhao
author_sort	Wei Liu
title	Extranodal natural killer/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series
title_short	Extranodal natural killer/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series
title_full	Extranodal natural killer/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series
title_fullStr	Extranodal natural killer/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series
title_full_unstemmed	Extranodal natural killer/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series
title_sort	extranodal natural killer/t-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series
publisher	BMC
publishDate	2021
url	https://doaj.org/article/241c8e423a8e48e89686a128b0103b38
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Extranodal natural killer/T-cell lymphoma of the breast: a retrospective clinicopathological analysis of a consecutive 11-year case series

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