Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity

Abstract Addition of nanoclays into a polymer matrix leads to nanocomposites with enhanced properties to be used in plastics for food packaging applications. Because of the plastics’ high stored energy value, such nanocomposites make good candidates for disposal via municipal solid waste plants. How...

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Autores principales:	Alixandra Wagner, Andrew P. White, Man Chio Tang, Sushant Agarwal, Todd A. Stueckle, Yon Rojanasakul, Rakesh K. Gupta, Cerasela Zoica Dinu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2420db8d839e4eada73f8f46ece1c961
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spelling	oai:doaj.org-article:2420db8d839e4eada73f8f46ece1c9612021-12-02T15:08:18ZIncineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity10.1038/s41598-018-28884-y2045-2322https://doaj.org/article/2420db8d839e4eada73f8f46ece1c9612018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28884-yhttps://doaj.org/toc/2045-2322Abstract Addition of nanoclays into a polymer matrix leads to nanocomposites with enhanced properties to be used in plastics for food packaging applications. Because of the plastics’ high stored energy value, such nanocomposites make good candidates for disposal via municipal solid waste plants. However, upon disposal, increased concerns related to nanocomposites’ byproducts potential toxicity arise, especially considering that such byproducts could escape disposal filters to cause inhalation hazards. Herein, we investigated the effects that byproducts of a polymer polylactic acid-based nanocomposite containing a functionalized montmorillonite nanoclay (Cloisite 30B) could pose to human lung epithelial cells, used as a model for inhalation exposure. Analysis showed that the byproducts induced toxic responses, including reductions in cellular viability, changes in cellular morphology, and cytoskeletal alterations, however only at high doses of exposure. The degree of dispersion of nanoclays in the polymer matrix appeared to influence the material characteristics, degradation, and ultimately toxicity. With toxicity of the byproduct occurring at high doses, safety protocols should be considered, along with deleterious effects investigations to thus help aid in safer, yet still effective products and disposal strategies.Alixandra WagnerAndrew P. WhiteMan Chio TangSushant AgarwalTodd A. StueckleYon RojanasakulRakesh K. GuptaCerasela Zoica DinuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alixandra Wagner Andrew P. White Man Chio Tang Sushant Agarwal Todd A. Stueckle Yon Rojanasakul Rakesh K. Gupta Cerasela Zoica Dinu Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity
description	Abstract Addition of nanoclays into a polymer matrix leads to nanocomposites with enhanced properties to be used in plastics for food packaging applications. Because of the plastics’ high stored energy value, such nanocomposites make good candidates for disposal via municipal solid waste plants. However, upon disposal, increased concerns related to nanocomposites’ byproducts potential toxicity arise, especially considering that such byproducts could escape disposal filters to cause inhalation hazards. Herein, we investigated the effects that byproducts of a polymer polylactic acid-based nanocomposite containing a functionalized montmorillonite nanoclay (Cloisite 30B) could pose to human lung epithelial cells, used as a model for inhalation exposure. Analysis showed that the byproducts induced toxic responses, including reductions in cellular viability, changes in cellular morphology, and cytoskeletal alterations, however only at high doses of exposure. The degree of dispersion of nanoclays in the polymer matrix appeared to influence the material characteristics, degradation, and ultimately toxicity. With toxicity of the byproduct occurring at high doses, safety protocols should be considered, along with deleterious effects investigations to thus help aid in safer, yet still effective products and disposal strategies.
format	article
author	Alixandra Wagner Andrew P. White Man Chio Tang Sushant Agarwal Todd A. Stueckle Yon Rojanasakul Rakesh K. Gupta Cerasela Zoica Dinu
author_facet	Alixandra Wagner Andrew P. White Man Chio Tang Sushant Agarwal Todd A. Stueckle Yon Rojanasakul Rakesh K. Gupta Cerasela Zoica Dinu
author_sort	Alixandra Wagner
title	Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity
title_short	Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity
title_full	Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity
title_fullStr	Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity
title_full_unstemmed	Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity
title_sort	incineration of nanoclay composites leads to byproducts with reduced cellular reactivity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2420db8d839e4eada73f8f46ece1c961
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Incineration of Nanoclay Composites Leads to Byproducts with Reduced Cellular Reactivity

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