Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer

Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer

Ying Liu, Peiwen Huang, Xuefeng Hou, Fei Yan, Zifei Jiang, Jiangpei Shi, Xingmei Xie, Junyi Shen, Qiangyuan Fan, Zhi Wang, Nianping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People’s Republic of ChinaBackground: Oral route of administrati...

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Autores principales: Liu Y, Huang P, Hou X, Yan F, Jiang Z, Shi J, Xie X, Shen J, Fan Q, Wang Z, Feng N
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Curcumin
IR780
Oral drug delivery
Lung metastasis of breast cancer
photo/chemotherapy
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/2420fa5fdf194f28912015c13d64dd78
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spelling oai:doaj.org-article:2420fa5fdf194f28912015c13d64dd782021-12-02T04:16:48ZHybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer1178-2013https://doaj.org/article/2420fa5fdf194f28912015c13d64dd782019-05-01T00:00:00Zhttps://www.dovepress.com/hybrid-curcumin-phospholipid-complex-near-infrared-dye-oral-drug-deliv-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ying Liu, Peiwen Huang, Xuefeng Hou, Fei Yan, Zifei Jiang, Jiangpei Shi, Xingmei Xie, Junyi Shen, Qiangyuan Fan, Zhi Wang, Nianping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People’s Republic of ChinaBackground: Oral route of administration is preferred for treating breast cancer, especially when continued disease management with good tolerability is required; however, orally administered chemotherapeutics combined with near-infrared (NIR) dyes are hindered by the low bioavailability, insufficient for the desired therapeutic efficacy. In this study, we developed a hybrid self-microemulsifying drug delivery system for co-loading curcumin–phospholipid complex and NIR dye IR780 (CUR/IR780@SMEDDS), to achieve combined phototherapeutic and chemotherapeutic effects against lung metastasis of breast cancer.Methods: CUR/IR780@SMEDDS were characterized. The efficacy against breast cancer metastasis was evaluated by photothermal and photodynamic assessment, cytotoxicity, invasion, and migration in metastatic 4T1 breast cancer cells in vitro, and in vivo oral bioavailability study in rats and pharmacodynamics studies in tumor-bearing nude mice.Results: CUR/IR780@SMEDDS improved oral bioavailability of curcumin and IR780 in rats compared with curcumin and IR780 suspensions. CUR/IR780@SMEDDS exhibited remarkable photothermal and photodynamic effects in vitro. In metastatic 4T1 breast cancer cells, CUR/IR780@SMEDDS combined with localized NIR laser irradiation induced significant cytotoxicity and inhibited invasion and migration of 4T1 cells, an outcome attributable to cumulative effects of IR780-induced hyperthermia and pharmacological effects of curcumin. In orthotopic 4T1 tumor-bearing nude mice, combination of oral administration of CUR/IR780@SMEDDS with local NIR laser irradiation inhibited tumor progression and suppressed lung metastasis.Keywords: curcumin, IR780, oral drug delivery, lung metastasis of breast cancer, photo/chemotherapyLiu YHuang PHou XYan FJiang ZShi JXie XShen JFan QWang ZFeng NDove Medical PressarticleCurcuminIR780Oral drug deliveryLung metastasis of breast cancerphoto/chemotherapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 3311-3330 (2019)
institution DOAJ
collection DOAJ
language EN
topic Curcumin
IR780
Oral drug delivery
Lung metastasis of breast cancer
photo/chemotherapy
Medicine (General)
R5-920
spellingShingle Curcumin
IR780
Oral drug delivery
Lung metastasis of breast cancer
photo/chemotherapy
Medicine (General)
R5-920
Liu Y
Huang P
Hou X
Yan F
Jiang Z
Shi J
Xie X
Shen J
Fan Q
Wang Z
Feng N
Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer
description Ying Liu, Peiwen Huang, Xuefeng Hou, Fei Yan, Zifei Jiang, Jiangpei Shi, Xingmei Xie, Junyi Shen, Qiangyuan Fan, Zhi Wang, Nianping FengSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, People’s Republic of ChinaBackground: Oral route of administration is preferred for treating breast cancer, especially when continued disease management with good tolerability is required; however, orally administered chemotherapeutics combined with near-infrared (NIR) dyes are hindered by the low bioavailability, insufficient for the desired therapeutic efficacy. In this study, we developed a hybrid self-microemulsifying drug delivery system for co-loading curcumin–phospholipid complex and NIR dye IR780 (CUR/IR780@SMEDDS), to achieve combined phototherapeutic and chemotherapeutic effects against lung metastasis of breast cancer.Methods: CUR/IR780@SMEDDS were characterized. The efficacy against breast cancer metastasis was evaluated by photothermal and photodynamic assessment, cytotoxicity, invasion, and migration in metastatic 4T1 breast cancer cells in vitro, and in vivo oral bioavailability study in rats and pharmacodynamics studies in tumor-bearing nude mice.Results: CUR/IR780@SMEDDS improved oral bioavailability of curcumin and IR780 in rats compared with curcumin and IR780 suspensions. CUR/IR780@SMEDDS exhibited remarkable photothermal and photodynamic effects in vitro. In metastatic 4T1 breast cancer cells, CUR/IR780@SMEDDS combined with localized NIR laser irradiation induced significant cytotoxicity and inhibited invasion and migration of 4T1 cells, an outcome attributable to cumulative effects of IR780-induced hyperthermia and pharmacological effects of curcumin. In orthotopic 4T1 tumor-bearing nude mice, combination of oral administration of CUR/IR780@SMEDDS with local NIR laser irradiation inhibited tumor progression and suppressed lung metastasis.Keywords: curcumin, IR780, oral drug delivery, lung metastasis of breast cancer, photo/chemotherapy
format article
author Liu Y
Huang P
Hou X
Yan F
Jiang Z
Shi J
Xie X
Shen J
Fan Q
Wang Z
Feng N
author_facet Liu Y
Huang P
Hou X
Yan F
Jiang Z
Shi J
Xie X
Shen J
Fan Q
Wang Z
Feng N
author_sort Liu Y
title Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer
title_short Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer
title_full Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer
title_fullStr Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer
title_full_unstemmed Hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer
title_sort hybrid curcumin–phospholipid complex-near-infrared dye oral drug delivery system to inhibit lung metastasis of breast cancer
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/2420fa5fdf194f28912015c13d64dd78
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