Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study

Abstract Blood eosinophil count is a useful measure in asthma or COPD management. Recent epidemiological studies revealed that body mass index (BMI) is positively associated with eosinophil counts. However, few studies focused on the role of adiposity and fatty acid-related metabolites on eosinophil...

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Autores principales:	Kenta Nishi, Hisako Matsumoto, Noriyuki Tashima, Satoru Terada, Natsuko Nomura, Mariko Kogo, Chie Morimoto, Hironobu Sunadome, Tadao Nagasaki, Tsuyoshi Oguma, Yoshinari Nakatsuka, Kimihiko Murase, Takahisa Kawaguchi, Yasuharu Tabara, Kazuhiro Sonomura, Fumihiko Matsuda, Kazuo Chin, Toyohiro Hirai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/24237fdc81344a8291481121115753db
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spelling	oai:doaj.org-article:24237fdc81344a8291481121115753db2021-12-02T16:31:02ZImpacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study10.1038/s41598-021-94835-92045-2322https://doaj.org/article/24237fdc81344a8291481121115753db2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94835-9https://doaj.org/toc/2045-2322Abstract Blood eosinophil count is a useful measure in asthma or COPD management. Recent epidemiological studies revealed that body mass index (BMI) is positively associated with eosinophil counts. However, few studies focused on the role of adiposity and fatty acid-related metabolites on eosinophil counts, including the effect of genetic polymorphism. In this community-based study involving 8265 participants (30–74 year old) from Nagahama city, we investigated the relationship between eosinophil counts and serum levels of fatty acid-related metabolites. The role of MDC1, a gene that is related to eosinophil counts in our previous study and encodes a protein that is thought to be involved in the repair of deoxyribonucleic acid damage, was also examined taking into account its interaction with adiposity. Serum levels of linoleic acid (LA) and β-hydroxybutyric acid (BHB) were negatively associated with eosinophil counts after adjustment with various confounders; however, there were positive interactions between serum LA and BMI and between serum BHB and BMI/body fat percentages in terms of eosinophil counts. In never-smokers, there was positive interaction for eosinophil counts between the CC genotype of MDC1 rs4713354 and BMI/body fat percentages. In conclusion, both serum LA and BHB have negative impacts on eosinophil counts, while adiposity shows robust positive effects on eosinophil counts, partly via genetic background in never-smokers.Kenta NishiHisako MatsumotoNoriyuki TashimaSatoru TeradaNatsuko NomuraMariko KogoChie MorimotoHironobu SunadomeTadao NagasakiTsuyoshi OgumaYoshinari NakatsukaKimihiko MuraseTakahisa KawaguchiYasuharu TabaraKazuhiro SonomuraFumihiko MatsudaKazuo ChinToyohiro HiraiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kenta Nishi Hisako Matsumoto Noriyuki Tashima Satoru Terada Natsuko Nomura Mariko Kogo Chie Morimoto Hironobu Sunadome Tadao Nagasaki Tsuyoshi Oguma Yoshinari Nakatsuka Kimihiko Murase Takahisa Kawaguchi Yasuharu Tabara Kazuhiro Sonomura Fumihiko Matsuda Kazuo Chin Toyohiro Hirai Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study
description	Abstract Blood eosinophil count is a useful measure in asthma or COPD management. Recent epidemiological studies revealed that body mass index (BMI) is positively associated with eosinophil counts. However, few studies focused on the role of adiposity and fatty acid-related metabolites on eosinophil counts, including the effect of genetic polymorphism. In this community-based study involving 8265 participants (30–74 year old) from Nagahama city, we investigated the relationship between eosinophil counts and serum levels of fatty acid-related metabolites. The role of MDC1, a gene that is related to eosinophil counts in our previous study and encodes a protein that is thought to be involved in the repair of deoxyribonucleic acid damage, was also examined taking into account its interaction with adiposity. Serum levels of linoleic acid (LA) and β-hydroxybutyric acid (BHB) were negatively associated with eosinophil counts after adjustment with various confounders; however, there were positive interactions between serum LA and BMI and between serum BHB and BMI/body fat percentages in terms of eosinophil counts. In never-smokers, there was positive interaction for eosinophil counts between the CC genotype of MDC1 rs4713354 and BMI/body fat percentages. In conclusion, both serum LA and BHB have negative impacts on eosinophil counts, while adiposity shows robust positive effects on eosinophil counts, partly via genetic background in never-smokers.
format	article
author	Kenta Nishi Hisako Matsumoto Noriyuki Tashima Satoru Terada Natsuko Nomura Mariko Kogo Chie Morimoto Hironobu Sunadome Tadao Nagasaki Tsuyoshi Oguma Yoshinari Nakatsuka Kimihiko Murase Takahisa Kawaguchi Yasuharu Tabara Kazuhiro Sonomura Fumihiko Matsuda Kazuo Chin Toyohiro Hirai
author_facet	Kenta Nishi Hisako Matsumoto Noriyuki Tashima Satoru Terada Natsuko Nomura Mariko Kogo Chie Morimoto Hironobu Sunadome Tadao Nagasaki Tsuyoshi Oguma Yoshinari Nakatsuka Kimihiko Murase Takahisa Kawaguchi Yasuharu Tabara Kazuhiro Sonomura Fumihiko Matsuda Kazuo Chin Toyohiro Hirai
author_sort	Kenta Nishi
title	Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study
title_short	Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study
title_full	Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study
title_fullStr	Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study
title_full_unstemmed	Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study
title_sort	impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the nagahama study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/24237fdc81344a8291481121115753db
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Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study

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