Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities

Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities

Necrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization in adaptive immune and innate lymphoid cells, dysr...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Steven X. Cho, Ina Rudloff, Jason C. Lao, Merrin A. Pang, Rimma Goldberg, Christine B. Bui, Catriona A. McLean, Magdalena Stock, Tilman E. Klassert, Hortense Slevogt, Niamh E. Mangan, Wei Cheng, Doris Fischer, Stefan Gfroerer, Manjeet K. Sandhu, Devi Ngo, Alexander Bujotzek, Laurent Lariviere, Felix Schumacher, Georg Tiefenthaler, Friederike Beker, Clare Collins, C. Omar F. Kamlin, Kai König, Atul Malhotra, Kenneth Tan, Christiane Theda, Alex Veldman, Andrew M. Ellisdon, James C. Whisstock, Philip J. Berger, Claudia A. Nold-Petry, Marcel F. Nold
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/242592c0bc1c49d49d4bb66a63310f56
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:242592c0bc1c49d49d4bb66a63310f56
record_format dspace
spelling oai:doaj.org-article:242592c0bc1c49d49d4bb66a63310f562021-12-02T14:41:13ZCharacterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities10.1038/s41467-020-19400-w2041-1723https://doaj.org/article/242592c0bc1c49d49d4bb66a63310f562020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19400-whttps://doaj.org/toc/2041-1723Necrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization in adaptive immune and innate lymphoid cells, dysregulated microbiota, and reduced interleukin-37 signaling.Steven X. ChoIna RudloffJason C. LaoMerrin A. PangRimma GoldbergChristine B. BuiCatriona A. McLeanMagdalena StockTilman E. KlassertHortense SlevogtNiamh E. ManganWei ChengDoris FischerStefan GfroererManjeet K. SandhuDevi NgoAlexander BujotzekLaurent LariviereFelix SchumacherGeorg TiefenthalerFriederike BekerClare CollinsC. Omar F. KamlinKai KönigAtul MalhotraKenneth TanChristiane ThedaAlex VeldmanAndrew M. EllisdonJames C. WhisstockPhilip J. BergerClaudia A. Nold-PetryMarcel F. NoldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Steven X. Cho
Ina Rudloff
Jason C. Lao
Merrin A. Pang
Rimma Goldberg
Christine B. Bui
Catriona A. McLean
Magdalena Stock
Tilman E. Klassert
Hortense Slevogt
Niamh E. Mangan
Wei Cheng
Doris Fischer
Stefan Gfroerer
Manjeet K. Sandhu
Devi Ngo
Alexander Bujotzek
Laurent Lariviere
Felix Schumacher
Georg Tiefenthaler
Friederike Beker
Clare Collins
C. Omar F. Kamlin
Kai König
Atul Malhotra
Kenneth Tan
Christiane Theda
Alex Veldman
Andrew M. Ellisdon
James C. Whisstock
Philip J. Berger
Claudia A. Nold-Petry
Marcel F. Nold
Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities
description Necrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization in adaptive immune and innate lymphoid cells, dysregulated microbiota, and reduced interleukin-37 signaling.
format article
author Steven X. Cho
Ina Rudloff
Jason C. Lao
Merrin A. Pang
Rimma Goldberg
Christine B. Bui
Catriona A. McLean
Magdalena Stock
Tilman E. Klassert
Hortense Slevogt
Niamh E. Mangan
Wei Cheng
Doris Fischer
Stefan Gfroerer
Manjeet K. Sandhu
Devi Ngo
Alexander Bujotzek
Laurent Lariviere
Felix Schumacher
Georg Tiefenthaler
Friederike Beker
Clare Collins
C. Omar F. Kamlin
Kai König
Atul Malhotra
Kenneth Tan
Christiane Theda
Alex Veldman
Andrew M. Ellisdon
James C. Whisstock
Philip J. Berger
Claudia A. Nold-Petry
Marcel F. Nold
author_facet Steven X. Cho
Ina Rudloff
Jason C. Lao
Merrin A. Pang
Rimma Goldberg
Christine B. Bui
Catriona A. McLean
Magdalena Stock
Tilman E. Klassert
Hortense Slevogt
Niamh E. Mangan
Wei Cheng
Doris Fischer
Stefan Gfroerer
Manjeet K. Sandhu
Devi Ngo
Alexander Bujotzek
Laurent Lariviere
Felix Schumacher
Georg Tiefenthaler
Friederike Beker
Clare Collins
C. Omar F. Kamlin
Kai König
Atul Malhotra
Kenneth Tan
Christiane Theda
Alex Veldman
Andrew M. Ellisdon
James C. Whisstock
Philip J. Berger
Claudia A. Nold-Petry
Marcel F. Nold
author_sort Steven X. Cho
title Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities
title_short Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities
title_full Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities
title_fullStr Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities
title_full_unstemmed Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities
title_sort characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/242592c0bc1c49d49d4bb66a63310f56
work_keys_str_mv AT stevenxcho characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT inarudloff characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT jasonclao characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT merrinapang characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT rimmagoldberg characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT christinebbui characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT catrionaamclean characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT magdalenastock characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT tilmaneklassert characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT hortenseslevogt characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT niamhemangan characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT weicheng characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT dorisfischer characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT stefangfroerer characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT manjeetksandhu characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT devingo characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT alexanderbujotzek characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT laurentlariviere characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT felixschumacher characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT georgtiefenthaler characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT friederikebeker characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT clarecollins characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT comarfkamlin characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT kaikonig characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT atulmalhotra characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT kennethtan characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT christianetheda characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT alexveldman characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT andrewmellisdon characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT jamescwhisstock characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT philipjberger characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT claudiaanoldpetry characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
AT marcelfnold characterizationofthepathoimmunologyofnecrotizingenterocolitisrevealsnoveltherapeuticopportunities
_version_ 1718389978748157952

Ejemplares similares