Antineutrophil cytoplasmic antibodies-associated glomerulonephritis: From bench to bedside

Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a group of autoimmune disorders that predominantly affects small vessels. The onset of the disease is closely associated with ANCA. Renal involvement, also known as ANCA-associated glomerulonephritis (AGN), is one of the mos...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yong-Xi Chen, Xiao-Nong Chen
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2018
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/24275348d96d4558a39117273d339ab2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:24275348d96d4558a39117273d339ab2
record_format	dspace
spelling	oai:doaj.org-article:24275348d96d4558a39117273d339ab22021-12-02T13:21:23ZAntineutrophil cytoplasmic antibodies-associated glomerulonephritis: From bench to bedside2095-882X10.1016/j.cdtm.2018.05.004https://doaj.org/article/24275348d96d4558a39117273d339ab22018-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X17301007https://doaj.org/toc/2095-882XAntineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a group of autoimmune disorders that predominantly affects small vessels. The onset of the disease is closely associated with ANCA. Renal involvement, also known as ANCA-associated glomerulonephritis (AGN), is one of the most common manifestations of AAV. In this mini-review, we described the clinical and pathological features of AGN. We then focused on recent studies on the mechanism of acute kidney lesions, including fibrinoid necrosis and crescent formation. Following the basic aspects of kidney injury in AGN, we demonstrated the clinical importance of kidney injury in determining the outcome of patients with AGN. The prognostic value of the 2010 Histopathological Classification of AGN and validating studies were summarized. Finally, treatment and novel therapeutic strategies were introduced addressing the importance of optimizing management of this patient population. Keywords: Antineutrophil cytoplasmic antibodies, Renal involvement, Prognosis, TreatmentYong-Xi ChenXiao-Nong ChenKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 4, Iss 3, Pp 187-191 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yong-Xi Chen Xiao-Nong Chen Antineutrophil cytoplasmic antibodies-associated glomerulonephritis: From bench to bedside
description	Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a group of autoimmune disorders that predominantly affects small vessels. The onset of the disease is closely associated with ANCA. Renal involvement, also known as ANCA-associated glomerulonephritis (AGN), is one of the most common manifestations of AAV. In this mini-review, we described the clinical and pathological features of AGN. We then focused on recent studies on the mechanism of acute kidney lesions, including fibrinoid necrosis and crescent formation. Following the basic aspects of kidney injury in AGN, we demonstrated the clinical importance of kidney injury in determining the outcome of patients with AGN. The prognostic value of the 2010 Histopathological Classification of AGN and validating studies were summarized. Finally, treatment and novel therapeutic strategies were introduced addressing the importance of optimizing management of this patient population. Keywords: Antineutrophil cytoplasmic antibodies, Renal involvement, Prognosis, Treatment
format	article
author	Yong-Xi Chen Xiao-Nong Chen
author_facet	Yong-Xi Chen Xiao-Nong Chen
author_sort	Yong-Xi Chen
title	Antineutrophil cytoplasmic antibodies-associated glomerulonephritis: From bench to bedside
title_short	Antineutrophil cytoplasmic antibodies-associated glomerulonephritis: From bench to bedside
title_full	Antineutrophil cytoplasmic antibodies-associated glomerulonephritis: From bench to bedside
title_fullStr	Antineutrophil cytoplasmic antibodies-associated glomerulonephritis: From bench to bedside
title_full_unstemmed	Antineutrophil cytoplasmic antibodies-associated glomerulonephritis: From bench to bedside
title_sort	antineutrophil cytoplasmic antibodies-associated glomerulonephritis: from bench to bedside
publisher	KeAi Communications Co., Ltd.
publishDate	2018
url	https://doaj.org/article/24275348d96d4558a39117273d339ab2
work_keys_str_mv	AT yongxichen antineutrophilcytoplasmicantibodiesassociatedglomerulonephritisfrombenchtobedside AT xiaonongchen antineutrophilcytoplasmicantibodiesassociatedglomerulonephritisfrombenchtobedside
_version_	1718393198662909952

Antineutrophil cytoplasmic antibodies-associated glomerulonephritis: From bench to bedside

Ejemplares similares