Intercontinental collaboration in clinical trials for children and adolescents with cancer—A systematic review by ACCELERATE

Abstract Background Since pediatric cancer drug development is a global enterprise, we sought to provide an overview of the landscape of intercontinental clinical trials in pediatric oncology opened over the last decade. Methods ClinicalTrials.gov was systematically searched to identify all clinical...

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Autores principales:	Teresa deRojas, Andrew J. Pearson, Nicole Scobie, Leona Knox, Darshan Wariabharaj, Pamela Kearns, Gilles Vassal, Gregory Reaman
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	adolescent cancer childhood cancer clinical research clinical trials drug development international collaboration Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2427915acca44221ada508c18a3dc005
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spelling	oai:doaj.org-article:2427915acca44221ada508c18a3dc0052021-12-01T04:49:15ZIntercontinental collaboration in clinical trials for children and adolescents with cancer—A systematic review by ACCELERATE2045-763410.1002/cam4.4356https://doaj.org/article/2427915acca44221ada508c18a3dc0052021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4356https://doaj.org/toc/2045-7634Abstract Background Since pediatric cancer drug development is a global enterprise, we sought to provide an overview of the landscape of intercontinental clinical trials in pediatric oncology opened over the last decade. Methods ClinicalTrials.gov was systematically searched to identify all clinical therapeutic trials which opened between 2010 and 2020 and recruited pediatric patients (<18 years) with cancer. Results Over the last 10 years, 295 (8.7%) of 3383 therapeutic pediatric cancer trials were international and 182 (5.4%) were intercontinental. Most intercontinental trials were phase‐1 or 2, with 25% late‐phase, 65% were sponsored by industry, and North America was involved in 92%. Industry‐sponsored proportionally more phase‐1 trials than academia (41% vs. 25%); conversely, academia sponsored more phase‐2 and late‐phase trials (39% and 31% vs. 36% and 21%, respectively) (p = 0.020). North America–Europe collaboration was predominantly industry sponsored as opposed to North America–Oceania and Europe–Oceania collaboration, more frequently academic (p < 0.0001). Most late‐phase trials (18/20, 90%) focusing on pediatric malignancies were conducted by academic sponsors and 10 of these were conducted by Children's Oncology Group (COG)/National Cancer Institute in the United States and Oceania. There was no significant increase over time of intercontinental trials and a trend for a reduction in academic trials. Conclusions Despite the relative rarity of childhood malignancies, especially within molecular subtypes, only 5.4% of pediatric cancer trials were intercontinental. The number of intercontinental trials remains small, with no significant increase over the last decade. The ACCELERATE International Collaboration Working Group aims to identify existing hurdles and propose solutions to improve intercontinental collaboration in clinical research for the benefit of children and adolescents with cancer.Teresa deRojasAndrew J. PearsonNicole ScobieLeona KnoxDarshan WariabharajPamela KearnsGilles VassalGregory ReamanWileyarticleadolescent cancerchildhood cancerclinical researchclinical trialsdrug developmentinternational collaborationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8462-8474 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adolescent cancer childhood cancer clinical research clinical trials drug development international collaboration Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	adolescent cancer childhood cancer clinical research clinical trials drug development international collaboration Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Teresa deRojas Andrew J. Pearson Nicole Scobie Leona Knox Darshan Wariabharaj Pamela Kearns Gilles Vassal Gregory Reaman Intercontinental collaboration in clinical trials for children and adolescents with cancer—A systematic review by ACCELERATE
description	Abstract Background Since pediatric cancer drug development is a global enterprise, we sought to provide an overview of the landscape of intercontinental clinical trials in pediatric oncology opened over the last decade. Methods ClinicalTrials.gov was systematically searched to identify all clinical therapeutic trials which opened between 2010 and 2020 and recruited pediatric patients (<18 years) with cancer. Results Over the last 10 years, 295 (8.7%) of 3383 therapeutic pediatric cancer trials were international and 182 (5.4%) were intercontinental. Most intercontinental trials were phase‐1 or 2, with 25% late‐phase, 65% were sponsored by industry, and North America was involved in 92%. Industry‐sponsored proportionally more phase‐1 trials than academia (41% vs. 25%); conversely, academia sponsored more phase‐2 and late‐phase trials (39% and 31% vs. 36% and 21%, respectively) (p = 0.020). North America–Europe collaboration was predominantly industry sponsored as opposed to North America–Oceania and Europe–Oceania collaboration, more frequently academic (p < 0.0001). Most late‐phase trials (18/20, 90%) focusing on pediatric malignancies were conducted by academic sponsors and 10 of these were conducted by Children's Oncology Group (COG)/National Cancer Institute in the United States and Oceania. There was no significant increase over time of intercontinental trials and a trend for a reduction in academic trials. Conclusions Despite the relative rarity of childhood malignancies, especially within molecular subtypes, only 5.4% of pediatric cancer trials were intercontinental. The number of intercontinental trials remains small, with no significant increase over the last decade. The ACCELERATE International Collaboration Working Group aims to identify existing hurdles and propose solutions to improve intercontinental collaboration in clinical research for the benefit of children and adolescents with cancer.
format	article
author	Teresa deRojas Andrew J. Pearson Nicole Scobie Leona Knox Darshan Wariabharaj Pamela Kearns Gilles Vassal Gregory Reaman
author_facet	Teresa deRojas Andrew J. Pearson Nicole Scobie Leona Knox Darshan Wariabharaj Pamela Kearns Gilles Vassal Gregory Reaman
author_sort	Teresa deRojas
title	Intercontinental collaboration in clinical trials for children and adolescents with cancer—A systematic review by ACCELERATE
title_short	Intercontinental collaboration in clinical trials for children and adolescents with cancer—A systematic review by ACCELERATE
title_full	Intercontinental collaboration in clinical trials for children and adolescents with cancer—A systematic review by ACCELERATE
title_fullStr	Intercontinental collaboration in clinical trials for children and adolescents with cancer—A systematic review by ACCELERATE
title_full_unstemmed	Intercontinental collaboration in clinical trials for children and adolescents with cancer—A systematic review by ACCELERATE
title_sort	intercontinental collaboration in clinical trials for children and adolescents with cancer—a systematic review by accelerate
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/2427915acca44221ada508c18a3dc005
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Intercontinental collaboration in clinical trials for children and adolescents with cancer—A systematic review by ACCELERATE

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