The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice.

The demonstration of the brain's ability to initiate repair in response to disease or injury has sparked considerable interest in therapeutic strategies to stimulate adult neurogenesis. In this study we examined the effect of a progressive neurodegenerative condition on neural precursor activit...

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Autores principales:	Tara L Walker, Geoff W Turnbull, Eirinn W Mackay, Anthony J Hannan, Perry F Bartlett
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/242801f0b4004932bdee9792d323abd9
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spelling	oai:doaj.org-article:242801f0b4004932bdee9792d323abd92021-11-18T06:56:50ZThe latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice.1932-620310.1371/journal.pone.0018153https://doaj.org/article/242801f0b4004932bdee9792d323abd92011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21455316/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The demonstration of the brain's ability to initiate repair in response to disease or injury has sparked considerable interest in therapeutic strategies to stimulate adult neurogenesis. In this study we examined the effect of a progressive neurodegenerative condition on neural precursor activity in the subventricular zone (SVZ) and hippocampus of the R6/1 transgenic mouse model of Huntington's disease (HD). Our results revealed an age-related decline in SVZ precursor numbers in both wild-type (WT) and HD mice. Interestingly, hippocampal precursor numbers declined with age in WT mice, although we observed maintenance in hippocampal precursor number in the HD animals in response to advancement of the disease. This maintenance was consistent with activation of a recently identified latent hippocampal precursor population. We found that the small latent stem cell population was also maintained in the HD hippocampus at 33 weeks, whereas it was not present in the WT. Our findings demonstrate that, despite a loss of neurogenesis in the HD hippocampus in vivo, there is a unique maintenance of the precursor and stem cells, which may potentially be activated to ameliorate disease symptoms.Tara L WalkerGeoff W TurnbullEirinn W MackayAnthony J HannanPerry F BartlettPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e18153 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tara L Walker Geoff W Turnbull Eirinn W Mackay Anthony J Hannan Perry F Bartlett The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice.
description	The demonstration of the brain's ability to initiate repair in response to disease or injury has sparked considerable interest in therapeutic strategies to stimulate adult neurogenesis. In this study we examined the effect of a progressive neurodegenerative condition on neural precursor activity in the subventricular zone (SVZ) and hippocampus of the R6/1 transgenic mouse model of Huntington's disease (HD). Our results revealed an age-related decline in SVZ precursor numbers in both wild-type (WT) and HD mice. Interestingly, hippocampal precursor numbers declined with age in WT mice, although we observed maintenance in hippocampal precursor number in the HD animals in response to advancement of the disease. This maintenance was consistent with activation of a recently identified latent hippocampal precursor population. We found that the small latent stem cell population was also maintained in the HD hippocampus at 33 weeks, whereas it was not present in the WT. Our findings demonstrate that, despite a loss of neurogenesis in the HD hippocampus in vivo, there is a unique maintenance of the precursor and stem cells, which may potentially be activated to ameliorate disease symptoms.
format	article
author	Tara L Walker Geoff W Turnbull Eirinn W Mackay Anthony J Hannan Perry F Bartlett
author_facet	Tara L Walker Geoff W Turnbull Eirinn W Mackay Anthony J Hannan Perry F Bartlett
author_sort	Tara L Walker
title	The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice.
title_short	The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice.
title_full	The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice.
title_fullStr	The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice.
title_full_unstemmed	The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice.
title_sort	latent stem cell population is retained in the hippocampus of transgenic huntington's disease mice but not wild-type mice.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/242801f0b4004932bdee9792d323abd9
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The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice.

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