Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with 10B-Borocaptate Sodium (BSH) and 10B-Paraboronophenylalanine (BPA)

Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy that utilizes the cancer targeting 10B-compound. Cancer cells that take up the compound are substantially damaged by the high liner energy transfer (LET) particles emitted mainly from the 10<...

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Autor principal:	Hiroshi Fukuda
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	BNCT normal tissue damage BSH BPA RBE CBE Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/242afb52f4eb4a05a5e7dd73eca2140d
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spelling	oai:doaj.org-article:242afb52f4eb4a05a5e7dd73eca2140d2021-11-25T17:08:30ZResponse of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with <sup>10</sup>B-Borocaptate Sodium (BSH) and <sup>10</sup>B-Paraboronophenylalanine (BPA)10.3390/cells101128832073-4409https://doaj.org/article/242afb52f4eb4a05a5e7dd73eca2140d2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2883https://doaj.org/toc/2073-4409Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy that utilizes the cancer targeting <sup>10</sup>B-compound. Cancer cells that take up the compound are substantially damaged by the high liner energy transfer (LET) particles emitted mainly from the <sup>10</sup>B(n, α<sup>7</sup>Li reaction. BNCT can minimize the dose to normal tissues, but it must be performed within the tolerable range of normal tissues. Therefore, it is important to evaluate the response of normal tissues to BNCT. Since BNCT yields a mixture of high and low LET radiations that make it difficult to understand the radiobiological basis of BNCT, it is important to evaluate the relative biological effectiveness (RBE) and compound biological effectiveness (CBE) factors for assessing the responses of normal tissues to BNCT. BSH and BPA are the only <sup>10</sup>B-compounds that can be used for clinical BNCT. Their biological behavior and cancer targeting mechanisms are different; therefore, they affect the CBE values differently. In this review, we present the RBE and CBE values of BPA or BSH for normal tissue damage by BNCT irradiation. The skin, brain (spinal cord), mucosa, lung, and liver are included as normal tissues. The CBE values of BPA and BSH for tumor control are also discussed.Hiroshi FukudaMDPI AGarticleBNCTnormal tissue damageBSHBPARBECBEBiology (General)QH301-705.5ENCells, Vol 10, Iss 2883, p 2883 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	BNCT normal tissue damage BSH BPA RBE CBE Biology (General) QH301-705.5
spellingShingle	BNCT normal tissue damage BSH BPA RBE CBE Biology (General) QH301-705.5 Hiroshi Fukuda Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with <sup>10</sup>B-Borocaptate Sodium (BSH) and <sup>10</sup>B-Paraboronophenylalanine (BPA)
description	Boron neutron capture therapy (BNCT) is a cancer-selective radiotherapy that utilizes the cancer targeting <sup>10</sup>B-compound. Cancer cells that take up the compound are substantially damaged by the high liner energy transfer (LET) particles emitted mainly from the <sup>10</sup>B(n, α<sup>7</sup>Li reaction. BNCT can minimize the dose to normal tissues, but it must be performed within the tolerable range of normal tissues. Therefore, it is important to evaluate the response of normal tissues to BNCT. Since BNCT yields a mixture of high and low LET radiations that make it difficult to understand the radiobiological basis of BNCT, it is important to evaluate the relative biological effectiveness (RBE) and compound biological effectiveness (CBE) factors for assessing the responses of normal tissues to BNCT. BSH and BPA are the only <sup>10</sup>B-compounds that can be used for clinical BNCT. Their biological behavior and cancer targeting mechanisms are different; therefore, they affect the CBE values differently. In this review, we present the RBE and CBE values of BPA or BSH for normal tissue damage by BNCT irradiation. The skin, brain (spinal cord), mucosa, lung, and liver are included as normal tissues. The CBE values of BPA and BSH for tumor control are also discussed.
format	article
author	Hiroshi Fukuda
author_facet	Hiroshi Fukuda
author_sort	Hiroshi Fukuda
title	Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with <sup>10</sup>B-Borocaptate Sodium (BSH) and <sup>10</sup>B-Paraboronophenylalanine (BPA)
title_short	Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with <sup>10</sup>B-Borocaptate Sodium (BSH) and <sup>10</sup>B-Paraboronophenylalanine (BPA)
title_full	Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with <sup>10</sup>B-Borocaptate Sodium (BSH) and <sup>10</sup>B-Paraboronophenylalanine (BPA)
title_fullStr	Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with <sup>10</sup>B-Borocaptate Sodium (BSH) and <sup>10</sup>B-Paraboronophenylalanine (BPA)
title_full_unstemmed	Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with <sup>10</sup>B-Borocaptate Sodium (BSH) and <sup>10</sup>B-Paraboronophenylalanine (BPA)
title_sort	response of normal tissues to boron neutron capture therapy (bnct) with <sup>10</sup>b-borocaptate sodium (bsh) and <sup>10</sup>b-paraboronophenylalanine (bpa)
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/242afb52f4eb4a05a5e7dd73eca2140d
work_keys_str_mv	AT hiroshifukuda responseofnormaltissuestoboronneutroncapturetherapybnctwithsup10supbborocaptatesodiumbshandsup10supbparaboronophenylalaninebpa
_version_	1718412700910878720

Response of Normal Tissues to Boron Neutron Capture Therapy (BNCT) with <sup>10</sup>B-Borocaptate Sodium (BSH) and <sup>10</sup>B-Paraboronophenylalanine (BPA)

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