Quantifying risk factors for human brucellosis in rural northern Tanzania.

<h4>Background</h4>Brucellosis is a zoonosis of veterinary, public health and economic significance in most developing countries. Human brucellosis is a severely debilitating disease that requires prolonged treatment with a combination of antibiotics. The disease can result in permanent...

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Autores principales:	Kunda John, Julie Fitzpatrick, Nigel French, Rudovick Kazwala, Dominic Kambarage, Godfrey S Mfinanga, Alastair MacMillan, Sarah Cleaveland
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/242b3af0b29944a992716c771bb91acb
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spelling	oai:doaj.org-article:242b3af0b29944a992716c771bb91acb2021-11-25T06:24:49ZQuantifying risk factors for human brucellosis in rural northern Tanzania.1932-620310.1371/journal.pone.0009968https://doaj.org/article/242b3af0b29944a992716c771bb91acb2010-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20376363/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Brucellosis is a zoonosis of veterinary, public health and economic significance in most developing countries. Human brucellosis is a severely debilitating disease that requires prolonged treatment with a combination of antibiotics. The disease can result in permanent and disabling sequel, and results in considerable medical expenses in addition to loss of income due to loss of working hours. A study was conducted in Northern Tanzania to determine the risk factors for transmission of brucellosis to humans in Tanzania.<h4>Methods</h4>This was a matched case-control study. Any patient with a positive result by a competitive ELISA (c-ELISA) test for brucellosis, and presenting to selected hospitals with at least two clinical features suggestive of brucellosis such as headache, recurrent or continuous fever, sweating, joint pain, joint swelling, general body malaise or backache, was defined as a case. For every case in a district, a corresponding control was traced and matched by sex using multistage cluster sampling. Other criteria for inclusion as a control included a negative c-ELISA test result and that the matched individual would present to hospital if falls sick.<h4>Results</h4>Multivariable analysis showed that brucellosis was associated with assisted parturition during abortion in cattle, sheep or goat. It was shown that individuals living in close proximity to other households had a higher risk of brucellosis. People who were of Christian religion were found to have a higher risk of brucellosis compared to other religions. The study concludes that assisting an aborting animal, proximity to neighborhoods, and Christianity were associated with brucellosis infection. There was no association between human brucellosis and Human Immunodeficiency Virus (HIV) serostatus. Protecting humans against contact with fluids and tissues during assisted parturition of livestock may be an important means of reducing the risk of transferring brucellosis from livestock to humans. These can be achieved through health education to the communities where brucellosis is common.Kunda JohnJulie FitzpatrickNigel FrenchRudovick KazwalaDominic KambarageGodfrey S MfinangaAlastair MacMillanSarah CleavelandPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 4, p e9968 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kunda John Julie Fitzpatrick Nigel French Rudovick Kazwala Dominic Kambarage Godfrey S Mfinanga Alastair MacMillan Sarah Cleaveland Quantifying risk factors for human brucellosis in rural northern Tanzania.
description	<h4>Background</h4>Brucellosis is a zoonosis of veterinary, public health and economic significance in most developing countries. Human brucellosis is a severely debilitating disease that requires prolonged treatment with a combination of antibiotics. The disease can result in permanent and disabling sequel, and results in considerable medical expenses in addition to loss of income due to loss of working hours. A study was conducted in Northern Tanzania to determine the risk factors for transmission of brucellosis to humans in Tanzania.<h4>Methods</h4>This was a matched case-control study. Any patient with a positive result by a competitive ELISA (c-ELISA) test for brucellosis, and presenting to selected hospitals with at least two clinical features suggestive of brucellosis such as headache, recurrent or continuous fever, sweating, joint pain, joint swelling, general body malaise or backache, was defined as a case. For every case in a district, a corresponding control was traced and matched by sex using multistage cluster sampling. Other criteria for inclusion as a control included a negative c-ELISA test result and that the matched individual would present to hospital if falls sick.<h4>Results</h4>Multivariable analysis showed that brucellosis was associated with assisted parturition during abortion in cattle, sheep or goat. It was shown that individuals living in close proximity to other households had a higher risk of brucellosis. People who were of Christian religion were found to have a higher risk of brucellosis compared to other religions. The study concludes that assisting an aborting animal, proximity to neighborhoods, and Christianity were associated with brucellosis infection. There was no association between human brucellosis and Human Immunodeficiency Virus (HIV) serostatus. Protecting humans against contact with fluids and tissues during assisted parturition of livestock may be an important means of reducing the risk of transferring brucellosis from livestock to humans. These can be achieved through health education to the communities where brucellosis is common.
format	article
author	Kunda John Julie Fitzpatrick Nigel French Rudovick Kazwala Dominic Kambarage Godfrey S Mfinanga Alastair MacMillan Sarah Cleaveland
author_facet	Kunda John Julie Fitzpatrick Nigel French Rudovick Kazwala Dominic Kambarage Godfrey S Mfinanga Alastair MacMillan Sarah Cleaveland
author_sort	Kunda John
title	Quantifying risk factors for human brucellosis in rural northern Tanzania.
title_short	Quantifying risk factors for human brucellosis in rural northern Tanzania.
title_full	Quantifying risk factors for human brucellosis in rural northern Tanzania.
title_fullStr	Quantifying risk factors for human brucellosis in rural northern Tanzania.
title_full_unstemmed	Quantifying risk factors for human brucellosis in rural northern Tanzania.
title_sort	quantifying risk factors for human brucellosis in rural northern tanzania.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/242b3af0b29944a992716c771bb91acb
work_keys_str_mv	AT kundajohn quantifyingriskfactorsforhumanbrucellosisinruralnortherntanzania AT juliefitzpatrick quantifyingriskfactorsforhumanbrucellosisinruralnortherntanzania AT nigelfrench quantifyingriskfactorsforhumanbrucellosisinruralnortherntanzania AT rudovickkazwala quantifyingriskfactorsforhumanbrucellosisinruralnortherntanzania AT dominickambarage quantifyingriskfactorsforhumanbrucellosisinruralnortherntanzania AT godfreysmfinanga quantifyingriskfactorsforhumanbrucellosisinruralnortherntanzania AT alastairmacmillan quantifyingriskfactorsforhumanbrucellosisinruralnortherntanzania AT sarahcleaveland quantifyingriskfactorsforhumanbrucellosisinruralnortherntanzania
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Quantifying risk factors for human brucellosis in rural northern Tanzania.

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