IMMUNOGLOBULIN A (IgA) AND ITS RECEPTORS

Abstract. Daily IgA production in human organism comprises 3 to 5 g, thus exceeding total synthesis of other Ig classes. IgA in human body is presented by 9 structural variants. Its molecules belong to two subclasses, IgA1 and IgA2, the latter represented by two allotypes. In human serum, IgA1 monom...

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Autores principales:	V. B. Klimovich, M. P. Samoilovich
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	iga receptors secretory iga Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/242cd181dc1d423b82f4b989457c8e44
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spelling	oai:doaj.org-article:242cd181dc1d423b82f4b989457c8e442021-11-18T08:03:41ZIMMUNOGLOBULIN A (IgA) AND ITS RECEPTORS1563-06252313-741X10.15789/1563-0625-2006-4-483-500https://doaj.org/article/242cd181dc1d423b82f4b989457c8e442014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/463https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Daily IgA production in human organism comprises 3 to 5 g, thus exceeding total synthesis of other Ig classes. IgA in human body is presented by 9 structural variants. Its molecules belong to two subclasses, IgA1 and IgA2, the latter represented by two allotypes. In human serum, IgA1 monomers predominate, that are produced by the bone marrow cells. Mucosa-associated lymphoid tissues produce dimeric IgA1 and IgA2 molecules containing an accessory polypeptide J-chain. When transported across epithelial layer to the mucosal surface, an extracellular segment of polymeric IgA receptor (pIgAR) is joining the dimeric IgA1, which becomes a ‘secretory’ component being a part cesretory IgA (sIgA) molecule. The main function of sIgA is to bind bacteria and viruses at the mucosal surfaces, thus preventing pathogens to invade the internal spaces of the organism (immune exclusion). If transferred across epithelium, IgA may neutralize the viruses penetrating the cells, like as bind and deliver proteins and other antigens to the mucosal surface. The leukocyte IgA receptor (FcαRI, CD89) is expressed on the neutrophils, eosinophiles, monocytes/macrophages, as well as dendritic and Kupffer cells. The cytoplasmic domain FcαRI is devoid of an activation ITAM motif. To transduce signal, an FcαRI-associated chain of Fcγ receptor is used. Due to this mechanism, IgA binding leads to activation of phagocytosis, endocytosis, antigen presentation, synthesis of proinflammatory mediator and other immune functions. Fcα/μR receptor is a structural homologue of pIgR, and it is able to bind IgA and IgM, being, however, expressed only at the surface of mature B lymphocytes and macrophages. Interaction of IgA with asialoglycoprotein and transferrin (CD71) receptors, like as with some other molecules, that have yet undetermined role in immune defense and development of pathological events.V. B. KlimovichM. P. SamoilovichSPb RAACIarticleigareceptorssecretory igaImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 8, Iss 4, Pp 483-500 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	iga receptors secretory iga Immunologic diseases. Allergy RC581-607
spellingShingle	iga receptors secretory iga Immunologic diseases. Allergy RC581-607 V. B. Klimovich M. P. Samoilovich IMMUNOGLOBULIN A (IgA) AND ITS RECEPTORS
description	Abstract. Daily IgA production in human organism comprises 3 to 5 g, thus exceeding total synthesis of other Ig classes. IgA in human body is presented by 9 structural variants. Its molecules belong to two subclasses, IgA1 and IgA2, the latter represented by two allotypes. In human serum, IgA1 monomers predominate, that are produced by the bone marrow cells. Mucosa-associated lymphoid tissues produce dimeric IgA1 and IgA2 molecules containing an accessory polypeptide J-chain. When transported across epithelial layer to the mucosal surface, an extracellular segment of polymeric IgA receptor (pIgAR) is joining the dimeric IgA1, which becomes a ‘secretory’ component being a part cesretory IgA (sIgA) molecule. The main function of sIgA is to bind bacteria and viruses at the mucosal surfaces, thus preventing pathogens to invade the internal spaces of the organism (immune exclusion). If transferred across epithelium, IgA may neutralize the viruses penetrating the cells, like as bind and deliver proteins and other antigens to the mucosal surface. The leukocyte IgA receptor (FcαRI, CD89) is expressed on the neutrophils, eosinophiles, monocytes/macrophages, as well as dendritic and Kupffer cells. The cytoplasmic domain FcαRI is devoid of an activation ITAM motif. To transduce signal, an FcαRI-associated chain of Fcγ receptor is used. Due to this mechanism, IgA binding leads to activation of phagocytosis, endocytosis, antigen presentation, synthesis of proinflammatory mediator and other immune functions. Fcα/μR receptor is a structural homologue of pIgR, and it is able to bind IgA and IgM, being, however, expressed only at the surface of mature B lymphocytes and macrophages. Interaction of IgA with asialoglycoprotein and transferrin (CD71) receptors, like as with some other molecules, that have yet undetermined role in immune defense and development of pathological events.
format	article
author	V. B. Klimovich M. P. Samoilovich
author_facet	V. B. Klimovich M. P. Samoilovich
author_sort	V. B. Klimovich
title	IMMUNOGLOBULIN A (IgA) AND ITS RECEPTORS
title_short	IMMUNOGLOBULIN A (IgA) AND ITS RECEPTORS
title_full	IMMUNOGLOBULIN A (IgA) AND ITS RECEPTORS
title_fullStr	IMMUNOGLOBULIN A (IgA) AND ITS RECEPTORS
title_full_unstemmed	IMMUNOGLOBULIN A (IgA) AND ITS RECEPTORS
title_sort	immunoglobulin a (iga) and its receptors
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/242cd181dc1d423b82f4b989457c8e44
work_keys_str_mv	AT vbklimovich immunoglobulinaigaanditsreceptors AT mpsamoilovich immunoglobulinaigaanditsreceptors
_version_	1718422468115300352

IMMUNOGLOBULIN A (IgA) AND ITS RECEPTORS

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