FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2

FANCD2-associated nuclease 1 (FAN1) is a key protein involved in the metabolism of DNA and in human pathologies. Here, the authors show that FAN1 directly interacts with PCNA at stalled replication forks to control their progression and prevent their collapse.

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Autores principales:	Antonio Porro, Matteo Berti, Julia Pizzolato, Serena Bologna, Svenja Kaden, Anja Saxer, Yue Ma, Kazuo Nagasawa, Alessandro A. Sartori, Josef Jiricny
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/242ed121c6a24d50ab52a5d2eada5647
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spelling	oai:doaj.org-article:242ed121c6a24d50ab52a5d2eada56472021-12-02T14:41:08ZFAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA210.1038/s41467-017-01074-62041-1723https://doaj.org/article/242ed121c6a24d50ab52a5d2eada56472017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01074-6https://doaj.org/toc/2041-1723FANCD2-associated nuclease 1 (FAN1) is a key protein involved in the metabolism of DNA and in human pathologies. Here, the authors show that FAN1 directly interacts with PCNA at stalled replication forks to control their progression and prevent their collapse.Antonio PorroMatteo BertiJulia PizzolatoSerena BolognaSvenja KadenAnja SaxerYue MaKazuo NagasawaAlessandro A. SartoriJosef JiricnyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antonio Porro Matteo Berti Julia Pizzolato Serena Bologna Svenja Kaden Anja Saxer Yue Ma Kazuo Nagasawa Alessandro A. Sartori Josef Jiricny FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2
description	FANCD2-associated nuclease 1 (FAN1) is a key protein involved in the metabolism of DNA and in human pathologies. Here, the authors show that FAN1 directly interacts with PCNA at stalled replication forks to control their progression and prevent their collapse.
format	article
author	Antonio Porro Matteo Berti Julia Pizzolato Serena Bologna Svenja Kaden Anja Saxer Yue Ma Kazuo Nagasawa Alessandro A. Sartori Josef Jiricny
author_facet	Antonio Porro Matteo Berti Julia Pizzolato Serena Bologna Svenja Kaden Anja Saxer Yue Ma Kazuo Nagasawa Alessandro A. Sartori Josef Jiricny
author_sort	Antonio Porro
title	FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2
title_short	FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2
title_full	FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2
title_fullStr	FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2
title_full_unstemmed	FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2
title_sort	fan1 interaction with ubiquitylated pcna alleviates replication stress and preserves genomic integrity independently of brca2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/242ed121c6a24d50ab52a5d2eada5647
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FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2

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