FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2
FANCD2-associated nuclease 1 (FAN1) is a key protein involved in the metabolism of DNA and in human pathologies. Here, the authors show that FAN1 directly interacts with PCNA at stalled replication forks to control their progression and prevent their collapse.
Guardado en:
Autores principales: | Antonio Porro, Matteo Berti, Julia Pizzolato, Serena Bologna, Svenja Kaden, Anja Saxer, Yue Ma, Kazuo Nagasawa, Alessandro A. Sartori, Josef Jiricny |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/242ed121c6a24d50ab52a5d2eada5647 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Author Correction: FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2
por: Antonio Porro, et al.
Publicado: (2017) -
Fan club /
por: Wallace, Irving 1916-1990
Publicado: (1984) -
Structural basis of human PCNA sliding on DNA
por: Matteo De March, et al.
Publicado: (2017) -
Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts
por: Ilias Georgakopoulos-Soares, et al.
Publicado: (2020) -
Anthropologist among fans
por: Srđan Radović
Publicado: (2016)