Polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis

Abstract Polypharmacy (PP) occurs in patients with type 2 diabetes (T2DM) owing to multimorbidity. We evaluated concomitant PP and medication adherence in T2DM 3 years after initiation of administration of a hypoglycaemic agent using a nationwide claim-based database in Japan. Factors associated wit...

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Autores principales:	Takeshi Horii, Makiko Iwasawa, Yusuke Kabeya, Koichiro Atuda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2430781ac5ab4bb1b22e866739c4b721
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spelling	oai:doaj.org-article:2430781ac5ab4bb1b22e866739c4b7212021-12-02T15:08:48ZPolypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis10.1038/s41598-019-49424-22045-2322https://doaj.org/article/2430781ac5ab4bb1b22e866739c4b7212019-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-49424-2https://doaj.org/toc/2045-2322Abstract Polypharmacy (PP) occurs in patients with type 2 diabetes (T2DM) owing to multimorbidity. We evaluated concomitant PP and medication adherence in T2DM 3 years after initiation of administration of a hypoglycaemic agent using a nationwide claim-based database in Japan. Factors associated with medication PP and imperfect adherence were identified using multivariable logistic regression. PP was defined as using ≥6 medications. Patients with proportion of days covered (PDC) of <80% were defined as having poor medication adherence. A total of 884 patients were analysed. Multivariate analysis revealed that age, total number of consultations and body mass index (BMI) are factors that influence PP. Factors associated with PDC < 80% were 2–3, 4–5 and ≥ 6 medications compared with 1 medication, male sex, <17 consultations and age 50–59 and ≥ 60 years compared with <40 years. In conclusion, older age, high total number of consultations and BMI ≥ 25 kg/m2 are risk factors for PP. PP influenced good medication adherence at the end of the observation period.Takeshi HoriiMakiko IwasawaYusuke KabeyaKoichiro AtudaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takeshi Horii Makiko Iwasawa Yusuke Kabeya Koichiro Atuda Polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis
description	Abstract Polypharmacy (PP) occurs in patients with type 2 diabetes (T2DM) owing to multimorbidity. We evaluated concomitant PP and medication adherence in T2DM 3 years after initiation of administration of a hypoglycaemic agent using a nationwide claim-based database in Japan. Factors associated with medication PP and imperfect adherence were identified using multivariable logistic regression. PP was defined as using ≥6 medications. Patients with proportion of days covered (PDC) of <80% were defined as having poor medication adherence. A total of 884 patients were analysed. Multivariate analysis revealed that age, total number of consultations and body mass index (BMI) are factors that influence PP. Factors associated with PDC < 80% were 2–3, 4–5 and ≥ 6 medications compared with 1 medication, male sex, <17 consultations and age 50–59 and ≥ 60 years compared with <40 years. In conclusion, older age, high total number of consultations and BMI ≥ 25 kg/m2 are risk factors for PP. PP influenced good medication adherence at the end of the observation period.
format	article
author	Takeshi Horii Makiko Iwasawa Yusuke Kabeya Koichiro Atuda
author_facet	Takeshi Horii Makiko Iwasawa Yusuke Kabeya Koichiro Atuda
author_sort	Takeshi Horii
title	Polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis
title_short	Polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis
title_full	Polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis
title_fullStr	Polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis
title_full_unstemmed	Polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis
title_sort	polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: a japanese database analysis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2430781ac5ab4bb1b22e866739c4b721
work_keys_str_mv	AT takeshihorii polypharmacyandoralantidiabetictreatmentfortype2diabetescharacterisedbydrugclassandpatientcharacteristicsajapanesedatabaseanalysis AT makikoiwasawa polypharmacyandoralantidiabetictreatmentfortype2diabetescharacterisedbydrugclassandpatientcharacteristicsajapanesedatabaseanalysis AT yusukekabeya polypharmacyandoralantidiabetictreatmentfortype2diabetescharacterisedbydrugclassandpatientcharacteristicsajapanesedatabaseanalysis AT koichiroatuda polypharmacyandoralantidiabetictreatmentfortype2diabetescharacterisedbydrugclassandpatientcharacteristicsajapanesedatabaseanalysis
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Polypharmacy and oral antidiabetic treatment for type 2 diabetes characterised by drug class and patient characteristics: A Japanese database analysis

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