The effects of repeated Ozurdex injections on ocular hypertension

Sepehr Bahadorani,1 Chelsey Krambeer,2 Kendall Wannamaker,1 Wayne Tie,1 Michael Jansen,1 Jason Espitia,2 Jeong-Hyeon Sohn,1 Michael A Singer2 1Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; 2Medical Center Ophthalmology Associates, San A...

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Autores principales:	Bahadorani S, Krambeer C, Wannamaker K, Tie W, Jansen M, Espitia J, Sohn JH, Singer MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Ozurdex dexamethasone glaucoma intraocular pressure ocular hypertension. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/2433c71603c14668878cba73086eba47
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spelling	oai:doaj.org-article:2433c71603c14668878cba73086eba472021-12-02T08:08:23ZThe effects of repeated Ozurdex injections on ocular hypertension1177-5483https://doaj.org/article/2433c71603c14668878cba73086eba472018-04-01T00:00:00Zhttps://www.dovepress.com/the-effects-of-repeated-ozurdex-injections-on-ocular-hypertension-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Sepehr Bahadorani,1 Chelsey Krambeer,2 Kendall Wannamaker,1 Wayne Tie,1 Michael Jansen,1 Jason Espitia,2 Jeong-Hyeon Sohn,1 Michael A Singer2 1Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; 2Medical Center Ophthalmology Associates, San Antonio, TX, USA Purpose: The purpose of this study was to correlate the degree of ocular hypertension with the number of Ozurdex injections.Methods: Intraocular pressure (IOP) fluctuations for a total of 183 injections were studied over a period of at least 12 months. The main indications for treatment were uveitis, diabetic macular edema, and retinal vein occlusion.Results: Results of the study demonstrate that repeated Ozurdex injections do not increase the frequency of IOP spikes beyond 30 mmHg. For lower IOPs, however, a positive correlation exists. Furthermore, patients with primary open angle glaucoma and uveitis had the highest IOP response to repeated injections. On average, patients with an IOP of ≥28.6 mmHg received pressure lowering medications, after which their IOP reached a stable level (16.7 mmHg) without the need for additional interventions.Conclusion: The data support the conclusion that multiple Ozurdex injections does not increase the frequency of IOP spikes beyond 30 mmHg, but patients still must be closely monitored if they have a history of primary open angle glaucoma. Keywords: Ozurdex, dexamethasone, glaucoma, intraocular pressure, ocular hypertensionBahadorani SKrambeer CWannamaker KTie WJansen MEspitia JSohn JHSinger MADove Medical PressarticleOzurdexdexamethasoneglaucomaintraocular pressureocular hypertension.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 639-642 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ozurdex dexamethasone glaucoma intraocular pressure ocular hypertension. Ophthalmology RE1-994
spellingShingle	Ozurdex dexamethasone glaucoma intraocular pressure ocular hypertension. Ophthalmology RE1-994 Bahadorani S Krambeer C Wannamaker K Tie W Jansen M Espitia J Sohn JH Singer MA The effects of repeated Ozurdex injections on ocular hypertension
description	Sepehr Bahadorani,1 Chelsey Krambeer,2 Kendall Wannamaker,1 Wayne Tie,1 Michael Jansen,1 Jason Espitia,2 Jeong-Hyeon Sohn,1 Michael A Singer2 1Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA; 2Medical Center Ophthalmology Associates, San Antonio, TX, USA Purpose: The purpose of this study was to correlate the degree of ocular hypertension with the number of Ozurdex injections.Methods: Intraocular pressure (IOP) fluctuations for a total of 183 injections were studied over a period of at least 12 months. The main indications for treatment were uveitis, diabetic macular edema, and retinal vein occlusion.Results: Results of the study demonstrate that repeated Ozurdex injections do not increase the frequency of IOP spikes beyond 30 mmHg. For lower IOPs, however, a positive correlation exists. Furthermore, patients with primary open angle glaucoma and uveitis had the highest IOP response to repeated injections. On average, patients with an IOP of ≥28.6 mmHg received pressure lowering medications, after which their IOP reached a stable level (16.7 mmHg) without the need for additional interventions.Conclusion: The data support the conclusion that multiple Ozurdex injections does not increase the frequency of IOP spikes beyond 30 mmHg, but patients still must be closely monitored if they have a history of primary open angle glaucoma. Keywords: Ozurdex, dexamethasone, glaucoma, intraocular pressure, ocular hypertension
format	article
author	Bahadorani S Krambeer C Wannamaker K Tie W Jansen M Espitia J Sohn JH Singer MA
author_facet	Bahadorani S Krambeer C Wannamaker K Tie W Jansen M Espitia J Sohn JH Singer MA
author_sort	Bahadorani S
title	The effects of repeated Ozurdex injections on ocular hypertension
title_short	The effects of repeated Ozurdex injections on ocular hypertension
title_full	The effects of repeated Ozurdex injections on ocular hypertension
title_fullStr	The effects of repeated Ozurdex injections on ocular hypertension
title_full_unstemmed	The effects of repeated Ozurdex injections on ocular hypertension
title_sort	effects of repeated ozurdex injections on ocular hypertension
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/2433c71603c14668878cba73086eba47
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The effects of repeated Ozurdex injections on ocular hypertension

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