Green synthesis of copper nanoparticles using Cinnamomum zelanicum extract and its applications as a highly efficient antioxidant and anti-human lung carcinoma

Cinnamomum zelanicum is one of the popular medicinal plants. The plant has many pharmaceutical uses in traditional medicine. In this study, copper nanoparticles were synthesized using the aqueous extract of Cinnamomum zelanicum. The CuNPs were characterized using different techniques such as EDX, FE...

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Autores principales:	Haocong Liu, Guan Wang, Jinpeng Liu, Kejun Nan, Jie Zhang, Lihong Guo, Yang Liu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	cinnamomum zelanicum leaf copper nanoparticles human lung carcinoma. Materials of engineering and construction. Mechanics of materials TA401-492 Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/243727b86bad4aebb74a19f1605782c1
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spelling	oai:doaj.org-article:243727b86bad4aebb74a19f1605782c12021-12-01T14:40:59ZGreen synthesis of copper nanoparticles using Cinnamomum zelanicum extract and its applications as a highly efficient antioxidant and anti-human lung carcinoma1745-80801745-809910.1080/17458080.2021.1991577https://doaj.org/article/243727b86bad4aebb74a19f1605782c12021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/17458080.2021.1991577https://doaj.org/toc/1745-8080https://doaj.org/toc/1745-8099Cinnamomum zelanicum is one of the popular medicinal plants. The plant has many pharmaceutical uses in traditional medicine. In this study, copper nanoparticles were synthesized using the aqueous extract of Cinnamomum zelanicum. The CuNPs were characterized using different techniques such as EDX, FE-SEM, XRD, and FT-IR. The FE-SEM results confirm spherical morphology for the nanoparticles with size of 19.55 to 69.70 nm. For investigating the antioxidant property of CuNPs, the DPPH test was used in the presence of butylated hydroxytoluene as the positive control. To survey the cytotoxicity and anti-human lung carcinoma effects of CuNPs, MTT assay was used on the NCI-H2126, NCI-H1437, NCI-H1573, and NCI-H661 cell lines. DPPH test revealed similar antioxidant potentials for Cinnamomum zelanicum aqueous extract, CuNPs, and butylated hydroxytoluene. Copper nanoparticles had very low cell viability and anti-lung carcinoma properties dose-dependently against NCI-H2126, NCI-H1437, NCI-H1573, and NCI-H66 cell lines without any cytotoxicity on the normal cell line. The best result of anti-lung carcinoma properties of CuNPs against the above cell lines was seen in the case of the NCI-H2126 cell line. According to the above findings, the copper nanoparticles containing Cinnamomum zelanicum can be administrated in humans for the treatment of several types of lung carcinoma.Haocong LiuGuan WangJinpeng LiuKejun NanJie ZhangLihong GuoYang LiuTaylor & Francis Grouparticlecinnamomum zelanicum leafcopper nanoparticleshuman lung carcinoma.Materials of engineering and construction. Mechanics of materialsTA401-492Chemical technologyTP1-1185ENJournal of Experimental Nanoscience, Vol 16, Iss 1, Pp 411-423 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cinnamomum zelanicum leaf copper nanoparticles human lung carcinoma. Materials of engineering and construction. Mechanics of materials TA401-492 Chemical technology TP1-1185
spellingShingle	cinnamomum zelanicum leaf copper nanoparticles human lung carcinoma. Materials of engineering and construction. Mechanics of materials TA401-492 Chemical technology TP1-1185 Haocong Liu Guan Wang Jinpeng Liu Kejun Nan Jie Zhang Lihong Guo Yang Liu Green synthesis of copper nanoparticles using Cinnamomum zelanicum extract and its applications as a highly efficient antioxidant and anti-human lung carcinoma
description	Cinnamomum zelanicum is one of the popular medicinal plants. The plant has many pharmaceutical uses in traditional medicine. In this study, copper nanoparticles were synthesized using the aqueous extract of Cinnamomum zelanicum. The CuNPs were characterized using different techniques such as EDX, FE-SEM, XRD, and FT-IR. The FE-SEM results confirm spherical morphology for the nanoparticles with size of 19.55 to 69.70 nm. For investigating the antioxidant property of CuNPs, the DPPH test was used in the presence of butylated hydroxytoluene as the positive control. To survey the cytotoxicity and anti-human lung carcinoma effects of CuNPs, MTT assay was used on the NCI-H2126, NCI-H1437, NCI-H1573, and NCI-H661 cell lines. DPPH test revealed similar antioxidant potentials for Cinnamomum zelanicum aqueous extract, CuNPs, and butylated hydroxytoluene. Copper nanoparticles had very low cell viability and anti-lung carcinoma properties dose-dependently against NCI-H2126, NCI-H1437, NCI-H1573, and NCI-H66 cell lines without any cytotoxicity on the normal cell line. The best result of anti-lung carcinoma properties of CuNPs against the above cell lines was seen in the case of the NCI-H2126 cell line. According to the above findings, the copper nanoparticles containing Cinnamomum zelanicum can be administrated in humans for the treatment of several types of lung carcinoma.
format	article
author	Haocong Liu Guan Wang Jinpeng Liu Kejun Nan Jie Zhang Lihong Guo Yang Liu
author_facet	Haocong Liu Guan Wang Jinpeng Liu Kejun Nan Jie Zhang Lihong Guo Yang Liu
author_sort	Haocong Liu
title	Green synthesis of copper nanoparticles using Cinnamomum zelanicum extract and its applications as a highly efficient antioxidant and anti-human lung carcinoma
title_short	Green synthesis of copper nanoparticles using Cinnamomum zelanicum extract and its applications as a highly efficient antioxidant and anti-human lung carcinoma
title_full	Green synthesis of copper nanoparticles using Cinnamomum zelanicum extract and its applications as a highly efficient antioxidant and anti-human lung carcinoma
title_fullStr	Green synthesis of copper nanoparticles using Cinnamomum zelanicum extract and its applications as a highly efficient antioxidant and anti-human lung carcinoma
title_full_unstemmed	Green synthesis of copper nanoparticles using Cinnamomum zelanicum extract and its applications as a highly efficient antioxidant and anti-human lung carcinoma
title_sort	green synthesis of copper nanoparticles using cinnamomum zelanicum extract and its applications as a highly efficient antioxidant and anti-human lung carcinoma
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/243727b86bad4aebb74a19f1605782c1
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Green synthesis of copper nanoparticles using Cinnamomum zelanicum extract and its applications as a highly efficient antioxidant and anti-human lung carcinoma

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