Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition

Abstract Gut microbial dysbiosis has been shown to be an instrumental factor in severe acute malnutrition (SAM) and particularly, the absence of Methanobrevibacter smithii, a key player in energy harvest. Nevertheless, it remains unknown whether this absence reflects an immaturity or a loss of the m...

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Autores principales:	Aminata Camara, Salimata Konate, Maryam Tidjani Alou, Aly Kodio, Amadou Hamidou Togo, Sebastien Cortaredona, Bernard Henrissat, Mahamadou Ali Thera, Ogobara K. Doumbo, Didier Raoult, Matthieu Million
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2439108a03c8439c9dd6d5efed17a89e
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spelling	oai:doaj.org-article:2439108a03c8439c9dd6d5efed17a89e2021-12-02T13:34:45ZClinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition10.1038/s41598-021-84641-82045-2322https://doaj.org/article/2439108a03c8439c9dd6d5efed17a89e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84641-8https://doaj.org/toc/2045-2322Abstract Gut microbial dysbiosis has been shown to be an instrumental factor in severe acute malnutrition (SAM) and particularly, the absence of Methanobrevibacter smithii, a key player in energy harvest. Nevertheless, it remains unknown whether this absence reflects an immaturity or a loss of the microbiota. In order to assess that, we performed a case–control study in Mali using a propensity score weighting approach. The presence of M. smithii was tested using quantitative PCR on faeces collected from SAM children at inclusion and at discharge when possible or at day 15 for controls. M. smithii was highly significantly associated with the absence of SAM, detected in 40.9% controls but only in 4.2% cases (p < 0.0001). The predictive positive value for detection of M. smithii gradually increased with age in controls while decreasing in cases. Among children providing two samples with a negative first sample, no SAM children became positive, while this proportion was 2/4 in controls (p = 0.0015). This data suggests that gut dysbiosis in SAM is not an immaturity but rather features a loss of M. smithii. The addition of M. smithii as a probiotic may thus represent an important addition to therapeutic approaches to restore gut symbiosis.Aminata CamaraSalimata KonateMaryam Tidjani AlouAly KodioAmadou Hamidou TogoSebastien CortaredonaBernard HenrissatMahamadou Ali TheraOgobara K. DoumboDidier RaoultMatthieu MillionNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aminata Camara Salimata Konate Maryam Tidjani Alou Aly Kodio Amadou Hamidou Togo Sebastien Cortaredona Bernard Henrissat Mahamadou Ali Thera Ogobara K. Doumbo Didier Raoult Matthieu Million Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition
description	Abstract Gut microbial dysbiosis has been shown to be an instrumental factor in severe acute malnutrition (SAM) and particularly, the absence of Methanobrevibacter smithii, a key player in energy harvest. Nevertheless, it remains unknown whether this absence reflects an immaturity or a loss of the microbiota. In order to assess that, we performed a case–control study in Mali using a propensity score weighting approach. The presence of M. smithii was tested using quantitative PCR on faeces collected from SAM children at inclusion and at discharge when possible or at day 15 for controls. M. smithii was highly significantly associated with the absence of SAM, detected in 40.9% controls but only in 4.2% cases (p < 0.0001). The predictive positive value for detection of M. smithii gradually increased with age in controls while decreasing in cases. Among children providing two samples with a negative first sample, no SAM children became positive, while this proportion was 2/4 in controls (p = 0.0015). This data suggests that gut dysbiosis in SAM is not an immaturity but rather features a loss of M. smithii. The addition of M. smithii as a probiotic may thus represent an important addition to therapeutic approaches to restore gut symbiosis.
format	article
author	Aminata Camara Salimata Konate Maryam Tidjani Alou Aly Kodio Amadou Hamidou Togo Sebastien Cortaredona Bernard Henrissat Mahamadou Ali Thera Ogobara K. Doumbo Didier Raoult Matthieu Million
author_facet	Aminata Camara Salimata Konate Maryam Tidjani Alou Aly Kodio Amadou Hamidou Togo Sebastien Cortaredona Bernard Henrissat Mahamadou Ali Thera Ogobara K. Doumbo Didier Raoult Matthieu Million
author_sort	Aminata Camara
title	Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition
title_short	Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition
title_full	Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition
title_fullStr	Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition
title_full_unstemmed	Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition
title_sort	clinical evidence of the role of methanobrevibacter smithii in severe acute malnutrition
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2439108a03c8439c9dd6d5efed17a89e
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Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition

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