Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling

Potassium channels such as MthK are presumed to have two allosterically coupled gates, the activation gate and the selectivity filter gate, that control gating transitions. Here authors use X-ray crystallography and molecular dynamics simulations on MthK and observe crosstalk between the gates.

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Autores principales:	Wojciech Kopec, Brad S. Rothberg, Bert L. de Groot
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2439150ab6a24c11a4d33e924d7c0ef7
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spelling	oai:doaj.org-article:2439150ab6a24c11a4d33e924d7c0ef72021-12-02T15:36:24ZMolecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling10.1038/s41467-019-13227-w2041-1723https://doaj.org/article/2439150ab6a24c11a4d33e924d7c0ef72019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13227-whttps://doaj.org/toc/2041-1723Potassium channels such as MthK are presumed to have two allosterically coupled gates, the activation gate and the selectivity filter gate, that control gating transitions. Here authors use X-ray crystallography and molecular dynamics simulations on MthK and observe crosstalk between the gates.Wojciech KopecBrad S. RothbergBert L. de GrootNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wojciech Kopec Brad S. Rothberg Bert L. de Groot Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling
description	Potassium channels such as MthK are presumed to have two allosterically coupled gates, the activation gate and the selectivity filter gate, that control gating transitions. Here authors use X-ray crystallography and molecular dynamics simulations on MthK and observe crosstalk between the gates.
format	article
author	Wojciech Kopec Brad S. Rothberg Bert L. de Groot
author_facet	Wojciech Kopec Brad S. Rothberg Bert L. de Groot
author_sort	Wojciech Kopec
title	Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling
title_short	Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling
title_full	Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling
title_fullStr	Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling
title_full_unstemmed	Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling
title_sort	molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2439150ab6a24c11a4d33e924d7c0ef7
work_keys_str_mv	AT wojciechkopec molecularmechanismofapotassiumchannelgatingthroughactivationgateselectivityfiltercoupling AT bradsrothberg molecularmechanismofapotassiumchannelgatingthroughactivationgateselectivityfiltercoupling AT bertldegroot molecularmechanismofapotassiumchannelgatingthroughactivationgateselectivityfiltercoupling
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Molecular mechanism of a potassium channel gating through activation gate-selectivity filter coupling

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