Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism.

The kinetics of recirculation of naive lymphocytes in the body has important implications for the speed at which local infections are detected and controlled by immune responses. With a help of a novel mathematical model, we analyze experimental data on migration of 51Cr-labeled thoracic duct lympho...

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Autores principales:	Vitaly V Ganusov, Jeremy Auerbach
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/2443936b56cd4baab1187f0f1d376ee3
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spelling	oai:doaj.org-article:2443936b56cd4baab1187f0f1d376ee32021-11-18T05:52:52ZMathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism.1553-734X1553-735810.1371/journal.pcbi.1003586https://doaj.org/article/2443936b56cd4baab1187f0f1d376ee32014-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24830705/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358The kinetics of recirculation of naive lymphocytes in the body has important implications for the speed at which local infections are detected and controlled by immune responses. With a help of a novel mathematical model, we analyze experimental data on migration of 51Cr-labeled thoracic duct lymphocytes (TDLs) via major lymphoid and nonlymphoid tissues of rats in the absence of systemic antigenic stimulation. We show that at any point of time, 95% of lymphocytes in the blood travel via capillaries in the lung or sinusoids of the liver and only 5% migrate to secondary lymphoid tissues such as lymph nodes, Peyer's patches, or the spleen. Interestingly, our analysis suggests that lymphocytes travel via lung capillaries and liver sinusoids at an extremely rapid rate with the average residence time in these tissues being less than 1 minute. The model also predicts a relatively short average residence time of TDLs in the spleen (2.5 hours) and a longer average residence time of TDLs in major lymph nodes and Peyer's patches (10 hours). Surprisingly, we find that the average residence time of lymphocytes is similar in lymph nodes draining the skin (subcutaneous LNs) or the gut (mesenteric LNs) or in Peyer's patches. Applying our model to an additional dataset on lymphocyte migration via resting and antigen-stimulated lymph nodes we find that enlargement of antigen-stimulated lymph nodes occurs mainly due to increased entrance rate of TDLs into the nodes and not due to decreased exit rate as has been suggested in some studies. Taken together, our analysis for the first time provides a comprehensive, systems view of recirculation kinetics of thoracic duct lymphocytes in the whole organism.Vitaly V GanusovJeremy AuerbachPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 10, Iss 5, p e1003586 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Vitaly V Ganusov Jeremy Auerbach Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism.
description	The kinetics of recirculation of naive lymphocytes in the body has important implications for the speed at which local infections are detected and controlled by immune responses. With a help of a novel mathematical model, we analyze experimental data on migration of 51Cr-labeled thoracic duct lymphocytes (TDLs) via major lymphoid and nonlymphoid tissues of rats in the absence of systemic antigenic stimulation. We show that at any point of time, 95% of lymphocytes in the blood travel via capillaries in the lung or sinusoids of the liver and only 5% migrate to secondary lymphoid tissues such as lymph nodes, Peyer's patches, or the spleen. Interestingly, our analysis suggests that lymphocytes travel via lung capillaries and liver sinusoids at an extremely rapid rate with the average residence time in these tissues being less than 1 minute. The model also predicts a relatively short average residence time of TDLs in the spleen (2.5 hours) and a longer average residence time of TDLs in major lymph nodes and Peyer's patches (10 hours). Surprisingly, we find that the average residence time of lymphocytes is similar in lymph nodes draining the skin (subcutaneous LNs) or the gut (mesenteric LNs) or in Peyer's patches. Applying our model to an additional dataset on lymphocyte migration via resting and antigen-stimulated lymph nodes we find that enlargement of antigen-stimulated lymph nodes occurs mainly due to increased entrance rate of TDLs into the nodes and not due to decreased exit rate as has been suggested in some studies. Taken together, our analysis for the first time provides a comprehensive, systems view of recirculation kinetics of thoracic duct lymphocytes in the whole organism.
format	article
author	Vitaly V Ganusov Jeremy Auerbach
author_facet	Vitaly V Ganusov Jeremy Auerbach
author_sort	Vitaly V Ganusov
title	Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism.
title_short	Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism.
title_full	Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism.
title_fullStr	Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism.
title_full_unstemmed	Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism.
title_sort	mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/2443936b56cd4baab1187f0f1d376ee3
work_keys_str_mv	AT vitalyvganusov mathematicalmodelingrevealskineticsoflymphocyterecirculationinthewholeorganism AT jeremyauerbach mathematicalmodelingrevealskineticsoflymphocyterecirculationinthewholeorganism
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Mathematical modeling reveals kinetics of lymphocyte recirculation in the whole organism.

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