The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data

Abstract While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent between early breast cancer (BC) and advanced BC. The study included 5099 patients with HER2 positive early BC (EBC) and 3496 with HER2 positive a...

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Autores principales:	Natansh D. Modi, Jin Quan Eugene Tan, Andrew Rowland, Bogda Koczwara, Ahmad Y. Abuhelwa, Ganessan Kichenadasse, Ross A. McKinnon, Michael D. Wiese, Michael J. Sorich, Ashley M. Hopkins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/24447a25e7ac4170bca7ea29c9ade681
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spelling	oai:doaj.org-article:24447a25e7ac4170bca7ea29c9ade6812021-12-02T11:44:49ZThe obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data10.1038/s41523-021-00241-92374-4677https://doaj.org/article/24447a25e7ac4170bca7ea29c9ade6812021-03-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00241-9https://doaj.org/toc/2374-4677Abstract While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent between early breast cancer (BC) and advanced BC. The study included 5099 patients with HER2 positive early BC (EBC) and 3496 with HER2 positive advanced BC (ABC). In the EBC cohort, higher BMI was associated with worse overall survival (OS) (HR [95% CI]: overweight = 1.30 [1.13–1.51]; obese = 1.37 [1.14–1.64], P = < 0.001), and worse disease-free survival (overweight = 1.10 [0.98–1.24]; obese = 1.20 [1.04–1.39], P = 0.061). In contrast, for the ABC cohort, higher BMI was significantly associated with improved OS (overweight = 0.85 [0.76–0.96]; obese = 0.82 [0.72–0.95], P = 0.014), and progression-free survival (overweight = 0.91 [0.83–1.01]; obese = 0.87 [0.77–0.98], P = 0.034). In this large high-quality dataset, higher BMI was independently associated with worse survival in EBC, paradoxically in ABC higher BMI was independently associated with improved survival.Natansh D. ModiJin Quan Eugene TanAndrew RowlandBogda KoczwaraAhmad Y. AbuhelwaGanessan KichenadasseRoss A. McKinnonMichael D. WieseMichael J. SorichAshley M. HopkinsNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Natansh D. Modi Jin Quan Eugene Tan Andrew Rowland Bogda Koczwara Ahmad Y. Abuhelwa Ganessan Kichenadasse Ross A. McKinnon Michael D. Wiese Michael J. Sorich Ashley M. Hopkins The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
description	Abstract While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent between early breast cancer (BC) and advanced BC. The study included 5099 patients with HER2 positive early BC (EBC) and 3496 with HER2 positive advanced BC (ABC). In the EBC cohort, higher BMI was associated with worse overall survival (OS) (HR [95% CI]: overweight = 1.30 [1.13–1.51]; obese = 1.37 [1.14–1.64], P = < 0.001), and worse disease-free survival (overweight = 1.10 [0.98–1.24]; obese = 1.20 [1.04–1.39], P = 0.061). In contrast, for the ABC cohort, higher BMI was significantly associated with improved OS (overweight = 0.85 [0.76–0.96]; obese = 0.82 [0.72–0.95], P = 0.014), and progression-free survival (overweight = 0.91 [0.83–1.01]; obese = 0.87 [0.77–0.98], P = 0.034). In this large high-quality dataset, higher BMI was independently associated with worse survival in EBC, paradoxically in ABC higher BMI was independently associated with improved survival.
format	article
author	Natansh D. Modi Jin Quan Eugene Tan Andrew Rowland Bogda Koczwara Ahmad Y. Abuhelwa Ganessan Kichenadasse Ross A. McKinnon Michael D. Wiese Michael J. Sorich Ashley M. Hopkins
author_facet	Natansh D. Modi Jin Quan Eugene Tan Andrew Rowland Bogda Koczwara Ahmad Y. Abuhelwa Ganessan Kichenadasse Ross A. McKinnon Michael D. Wiese Michael J. Sorich Ashley M. Hopkins
author_sort	Natansh D. Modi
title	The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
title_short	The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
title_full	The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
title_fullStr	The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
title_full_unstemmed	The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data
title_sort	obesity paradox in early and advanced her2 positive breast cancer: pooled analysis of clinical trial data
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/24447a25e7ac4170bca7ea29c9ade681
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The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data

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