Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018

Abstract Background Rotavirus (RV) vaccines are available in Spain since 2006 but are not included in the National Immunization Program. RV vaccination has reached an intermediate vaccination coverage rate (VCR) but with substantial differences between provinces. The aim of this study was to assess...

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Autores principales:	J. Ruiz-Contreras, S. Alfayate-Miguelez, B. Carazo-Gallego, E. Onís, L. Díaz-Munilla, M. Mendizabal, M. Méndez Hernández, B. Ferrer-Lorente, M. Unsaín-Mancisidor, J. T. Ramos-Amador, B. Croche-Santander, F. Centeno Malfaz, J. Rodríguez-Suárez, M. Cotarelo, M. San-Martín, J. Arístegui
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Rotavirus Acute Gastroenteritis Hospitalization Vaccination coverage rate Spain Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/24469df4624941b1a0ae5865a996957a
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spelling	oai:doaj.org-article:24469df4624941b1a0ae5865a996957a2021-11-08T11:18:21ZRotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–201810.1186/s12879-021-06841-x1471-2334https://doaj.org/article/24469df4624941b1a0ae5865a996957a2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06841-xhttps://doaj.org/toc/1471-2334Abstract Background Rotavirus (RV) vaccines are available in Spain since 2006 but are not included in the National Immunization Program. RV vaccination has reached an intermediate vaccination coverage rate (VCR) but with substantial differences between provinces. The aim of this study was to assess the ratio of RV gastroenteritis (RVGE) admissions to all-cause hospitalizations in children under 5 years of age in areas with different VCR. Methods Observational, multicenter, cross-sectional, medical record-based study. All children admitted to the study hospitals with a RVGE confirmed diagnosis during a 5-year period were selected. The annual ratio of RVGE to the total number of all-cause hospitalizations in children < 5 years of age were calculated. The proportion of RVGE hospitalizations were compared in areas with low (< 30%), intermediate (31–59%) and high (> 60%) VCR. Results From June 2013 to May 2018, data from 1731 RVGE hospitalizations (16.47% of which were nosocomial) were collected from the 12 study hospitals. RVGE hospital admissions accounted for 2.82% (95 CI 2.72–3.00) and 43.84% (95% CI 40.53–47.21) of all-cause and Acute Gastroenteritis (AGE) hospitalizations in children under 5 years of age, respectively. The likelihood of hospitalization due to RVGE was 56% (IC95%, 51–61%) and 27% (IC95%, 18–35%) lower in areas with high and intermediate VCR, respectively, compared to the low VCR areas. Conclusions RVGE hospitalization ratios are highly dependent on the RV VCR. Increasing VCR in areas with intermediate and low coverage rates would significantly reduce the severe burden of RVGE that requires hospital management in Spain. Clinical trial registration Not applicableJ. Ruiz-ContrerasS. Alfayate-MiguelezB. Carazo-GallegoE. OnísL. Díaz-MunillaM. MendizabalM. Méndez HernándezB. Ferrer-LorenteM. Unsaín-MancisidorJ. T. Ramos-AmadorB. Croche-SantanderF. Centeno MalfazJ. Rodríguez-SuárezM. CotareloM. San-MartínJ. ArísteguiBMCarticleRotavirusAcute GastroenteritisHospitalizationVaccination coverage rateSpainInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Rotavirus Acute Gastroenteritis Hospitalization Vaccination coverage rate Spain Infectious and parasitic diseases RC109-216
spellingShingle	Rotavirus Acute Gastroenteritis Hospitalization Vaccination coverage rate Spain Infectious and parasitic diseases RC109-216 J. Ruiz-Contreras S. Alfayate-Miguelez B. Carazo-Gallego E. Onís L. Díaz-Munilla M. Mendizabal M. Méndez Hernández B. Ferrer-Lorente M. Unsaín-Mancisidor J. T. Ramos-Amador B. Croche-Santander F. Centeno Malfaz J. Rodríguez-Suárez M. Cotarelo M. San-Martín J. Arístegui Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018
description	Abstract Background Rotavirus (RV) vaccines are available in Spain since 2006 but are not included in the National Immunization Program. RV vaccination has reached an intermediate vaccination coverage rate (VCR) but with substantial differences between provinces. The aim of this study was to assess the ratio of RV gastroenteritis (RVGE) admissions to all-cause hospitalizations in children under 5 years of age in areas with different VCR. Methods Observational, multicenter, cross-sectional, medical record-based study. All children admitted to the study hospitals with a RVGE confirmed diagnosis during a 5-year period were selected. The annual ratio of RVGE to the total number of all-cause hospitalizations in children < 5 years of age were calculated. The proportion of RVGE hospitalizations were compared in areas with low (< 30%), intermediate (31–59%) and high (> 60%) VCR. Results From June 2013 to May 2018, data from 1731 RVGE hospitalizations (16.47% of which were nosocomial) were collected from the 12 study hospitals. RVGE hospital admissions accounted for 2.82% (95 CI 2.72–3.00) and 43.84% (95% CI 40.53–47.21) of all-cause and Acute Gastroenteritis (AGE) hospitalizations in children under 5 years of age, respectively. The likelihood of hospitalization due to RVGE was 56% (IC95%, 51–61%) and 27% (IC95%, 18–35%) lower in areas with high and intermediate VCR, respectively, compared to the low VCR areas. Conclusions RVGE hospitalization ratios are highly dependent on the RV VCR. Increasing VCR in areas with intermediate and low coverage rates would significantly reduce the severe burden of RVGE that requires hospital management in Spain. Clinical trial registration Not applicable
format	article
author	J. Ruiz-Contreras S. Alfayate-Miguelez B. Carazo-Gallego E. Onís L. Díaz-Munilla M. Mendizabal M. Méndez Hernández B. Ferrer-Lorente M. Unsaín-Mancisidor J. T. Ramos-Amador B. Croche-Santander F. Centeno Malfaz J. Rodríguez-Suárez M. Cotarelo M. San-Martín J. Arístegui
author_facet	J. Ruiz-Contreras S. Alfayate-Miguelez B. Carazo-Gallego E. Onís L. Díaz-Munilla M. Mendizabal M. Méndez Hernández B. Ferrer-Lorente M. Unsaín-Mancisidor J. T. Ramos-Amador B. Croche-Santander F. Centeno Malfaz J. Rodríguez-Suárez M. Cotarelo M. San-Martín J. Arístegui
author_sort	J. Ruiz-Contreras
title	Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018
title_short	Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018
title_full	Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018
title_fullStr	Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018
title_full_unstemmed	Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018
title_sort	rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in spain, 2013–2018
publisher	BMC
publishDate	2021
url	https://doaj.org/article/24469df4624941b1a0ae5865a996957a
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Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018

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